Single-molecule biophysics lab at Goethe University Frankfurt. Super-resolution microscopy. We moved 👉🏻 https://nitter.cf/t.co/hdHe9TrOnJ
Frankfurt, Germany
Joined September 2021
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Two great days of science at the #SMLMS2022, culminating with a conference dinner on the boat on the Seine. So many great conversations 🙏. Happy to present our choreography to show our appreciation to this event (watch the light pattern!).
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. rdcu.be/d3dmN
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
Open postdoctoral position in my group! jobs-sf.ukmuenster.de/job/UK… We search for a very talented student in the field of super resolution microscopy! @UK_Muenster @uni_muenster #academia #newPI
We modified our STED🔬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3D cell volume. This enabled collecting a large amount of data in a fully automated fashion. With that, we visualized the ultra-structure a nuclear body👇🏻(1/3)
By labeling the architectural RNA NEAT1 in paraspeckles (PS) at various positions using RNA-FISH-DNA-LNA probes, we learnt 3 new things: (1) the morphological space & shape progression of PS, (2) the orientation/packing of its RNA, (3) the coarse conformation of NEAT1. (2/3)
Kudos to Enya & Laurell for their fantastic work! Great collab🙏w/ Bernd Rieger & Sjoerd Stallinga (TU Delft) Michaela MüllerMcNicoll (@goetheuni) & great support by @ashwin0512. We are very excited about the results & curious to see your feedback 👉🏻 doi.org/10.1101/2024.11.28.6…
bsky.app/profile/heilemannla…
🙏hoping to re-connect to many of you
Long-term single-protein tracking up to 30 min allowed monitoring the dynamics of EGFR activation in living cells (and more)👇🏻Great work by a fantastic team and great collaboration with @JulianKompa Kai Johnsson @mpi_mr_hd 🙏 @sfb1507 @goetheuni
Long-Term Single-Molecule Tracking in Living Cells using Weak-Affinity Protein Labeling (Mike Heilemann and co-workers) @HeilemannLab #openaccess onlinelibrary.wiley.com/doi/…
🙏happy that this article is out now: we used an integrative approach (MD, single-molecule imaging, FRET) to reveal early activation of the receptor tyrosine kinase MET in cells👇🏻A wonderful collaboration with @CovinoLab & great co-workers 🙏@goetheuni @fias_science @sfb1507
Check out how we used simulations and single molecule FRET to determine how a invasion bacterial protein activates a plasma membrane receptor to enter our cells. Kudos to @serena_arghittu and @gabriel_hella, and great collaboration with @HeilemannLab
nature.com/articles/s41467-0…
Many thanks to the reviewers for great input (yes) and to the Editor & team of @NatureComms 🙏
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
Gen-AI producing fancy data augmentation for Super-resolution microscopy! Great work @AlonSaguy and team! @HenriquesLab @HeilemannLab
If robots could dream of microtubules, how would they look like? An amazing story by Alon Saguy, @ShechtmanLab and colleagues. Proud we could contribute to it
onlinelibrary.wiley.com/doi/…
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
Our Gentle Rhodamines is finally published @ACSCentSci.
See the healthy cytoskeleton free from photodamage even after 800 frames! 🦾💪
pubs.acs.org/doi/10.1021/acs…
Great collaboration with Julian Kompa, the Johnsson group, and Spirochrome! @JulianKompa @spirochrome @TianyanL
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
3 weeks to go... send us your single-molecule bacterial stories for our Cotswolds get-together!
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab!
doi.org/10.1038/s41592-024-0… 1/11
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
Why reinvent the wheel when you can enhance it? We’ve focused on making SNAP-tag better. @SteffiKuehn developed SNAP-tag2, with an optimized substrate. Faster labeling, brighter fluorescence-this is the upgrade you've been waiting for!
Preprint alert🚨Did you ever experience issues in labeling kinetics and fluorescence brightness, when working with SNAP-tag in live cells?
Our newly developed SNAP-tag2 system might be the solution!
🚀Check out our latest preprint on #bioRxiv: 🔗biorxiv.org/content/10.1101/…
(1/4)
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
We see each other next year in Bonn, Germany in #SMLMS2025 hosted by @UEndesfelder and @HeilemannLab
I am chiming in: fantastic meeting, congratulations and thank you to @HenriquesLab and @MicrobeMatos & entire team! #SMLMS2024 @SMLM_Symposium
Looking forward to #SMLMS2025 and working with @UEndesfelder to make it happen. The bar is high 😅. Hope to see you all again in Bonn!
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Well done, Claudia! 👍
Claudia Catapano from @HeilemannLab presented her PhD work using Single Particle Tracking #SPT to study ligand-dependent membrane receptor activation 🧫 #SMLMS2024 @SMLM_Symposium
HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
our next talk features @JumanaAHA and her impressive work on chromosomal homolog interactions 🧬🔬 Jumana is also a new PI hiring, start applying now 😊 #SMLMS2024 @SMLM_Symposium
👉🏻 great job opportunity for a PhD/Postdoc in a new lab headed by a great young PI 👉🏻 @miCHRIScopy.
Exciting research in a great research environment!
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HeilemannLab (👉🏻 heilemannlab.bsky.social) retweeted
SMLM community! #SMLMS2024 check out our new preprint, a searchable repository (nano-org) for biological SMLM data allowing comparisons of nanoscale organisation 👨🏻💻 🗃🔢. Registrations data for uploads encouraged 😃. Links below.
nano-org.bham.ac.uk
biorxiv.org/content/10.1101/…