Explorative #naturalproducts genomics at #goetheuni Frankfurt and #LOEWE_TBG. Institute for Molecular Bio Science I Tweets by lab members
Frankfurt am Main
Joined November 2020
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Our study in ACS Chem Biol reveals a unique eunicellane pathway featuring a reductase fused with a terpene cyclase, a P450 split into 3 fragments and a hypothetical protein with dual isomerase and oxygenase functions!
pubs.acs.org/doi/full/10.102…
Helfrich Lab retweeted
🔓Don't miss this #OpenAccess article in our latest issue by Eric Helfrich et al. @goetheuni looking at the role and mechanisms of canonical and non-canonical tailoring enzymes in bacterial terpenoid biosynthesis
Check it out in full on our website👇
pubs.rsc.org/en/content/arti…
🚨fully funded #PhD positions - apply by February 7th🚨
The International Max Planck Research School in Frankfurt in recruiting!
The Helfrich lab is especially looking for a bioinformaticist skilled in Python & Machine Learning to join our team!
#Bioinformatics #PhDposition
Helfrich Lab retweeted
Happy to report that our work on immune system adaptations in #bats is now out in @Nature 🦇🧬nature.com/articles/s41586-0… @_AriadnaMorales @BatResearch @sci_questions @bat1kgenomes @Senckenberg @LOEWE_TBG Read more ...
Helfrich Lab retweeted
After 7⃣ exciting years, @LOEWE_TBG as a project ends, but we’re excited to continue as a collaborative network with new initiatives. 💪🧬
Thank you to our funder @HMWK_Hessen, partners, advisors & colleagues for the invaluable support.🙏 Wishing you a successful New Year 2025!🎉
Helfrich Lab retweeted
Interested in chemo-enzymatic synthesis; or in biosynthetic engineering? Here is our Christmas treat to you: onlinelibrary.wiley.com/doi/…
This took a while but turned out very nicely. Thanks to everyone involved, including @ManuEinsiedler, @sschneider_lab, Sebastian and team PoTeM!
Helfrich Lab retweeted
Postdoc position available jointly between the lab of @BEDutilh and myself: uu.nl/en/organisation/workin…
Come join us!
Helfrich Lab retweeted
Happy to share our first independent work just out @angew_chem: Natural methyl analogs of central sesquiterpenes widespread in actinobacteria! Exciting enzyme chemistry. Curious why they exist. A hidden "magic methyl effect" in the terpene world? onlinelibrary.wiley.com/doi/…
Helfrich Lab retweeted
Check out our new opinion paper on plant biosynthetic pathway discovery, spearheaded by #FeliciaWolters, @elena_delpup et al.
How do we pair omics to decode the diversity of 🌱plant specialized metabolism? In our latest paper, we present a perspective on how paired omics can support a collaborative effort to characterise the plant metabolome. @marnixmedema @jjjvanderhooft
sciencedirect.com/science/ar…
Helfrich Lab retweeted
The #BJOC thematic issue on Young investigators in natural products chemistry, biosynthesis, and enzymology is now complete! 31 contributions from young investigators around the world! Check it out! @BeilsteinInst beilstein-journals.org/bjoc/…
A P450 and the hypothetical protein in our study show partial functional redundancy. Some euthainols associated with the pathway show unique oxygenation patterns compared to known eunicellanes. Notably, some euthainols show antibiotic properties against ESKAPE pathogens
This study was a true collaborative effort among the Clardy, Voigt, Ueoka, Walker and Helfrich labs led by our talented first authors Ayesha Ahmed Chaushri, Yuya Kakumu, @SirinTH229, and @ctliu629. Proud to share the results of this teamwork!
We developed a versatile genome mining strategy to explore the biosynthetic space of the atropopeptides - a fascinating family of peptides with complex 3D shapes!
Now out in @ChemicalScience
#peptides #biosynthesis #genomemining
pubs.rsc.org/en/content/arti…
We redefined the atropopeptide family of ribosomally synthesized and posttranslationally modified peptides and uncovered several new members of the peptide family with varying peptide length and structural complexity
Great work by @Friederike82360, Bin Tan, Milena Breitenbach, Yuya Kakumu, Pakjira Nanudorn, Yoana Dimitrova and our amazing collaboration partners Allison Walker and Reiko Ueoka
#proudPI
Helfrich Lab retweeted
We held our 10th and final retreat of @LOEWE_TBG in #Glashütten, in the beautiful #Taunus! It was the perfect blend of engaging discussions, hiking, nostalgia, and exciting plans.💪
So nice to have the whole team together — thank you all for the amazing time! 😍
Helfrich Lab retweeted
Deborah Leigh, newly appointed Professor of Genomic Biomonitoring @Senckenberg & @goetheuni in Frankfurt am Main, is exploring the genetic diversity 🧬 of living organisms to contribute to their conservation. 🌍
A warm welcome @LOEWE_TBG, Deborah!
ℹ️ sgn.one/94q
ALT Photo: Sven Tränkner
Helfrich Lab retweeted
Paper party!🥳🙌🏻 Our paper on the chromosome-level genome assembly of Elysia timida is published! Thanks to all my co-authors, @CarolaGreve, @GaliaCampsOmics, Tilman, Alex, Charlotte, Damian, Julia, Eric & Kornelia!🎉
@LOEWE_TBG @Senckenberg @BioMedCentral rdcu.be/dWku3
Helfrich Lab retweeted
New pub today in @PNASNews that extends our @noaacoastalsci ECOHAB work at @Scripps_Ocean on domoic acid biosynthesis with @Andreweallen to support toxin forecasting during an oceanic diatom bloom pnas.org/doi/10.1073/pnas.23…
Helfrich Lab retweeted
Thanks for this wonderful collaboration. It was so much fun to make this happen with you @ChekanLab @sanathrajkk0 😎
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