Jamie Kuzich (@JantonKay) profile picture

Jamie Kuzich

@JantonKay

Haematologist & Postdoc @TheDawsonLab @PeterMacCC // Therapy resistance in acute leukaemia and lymphoma

 Melbourne, Australia
Joined August 2011
  • Tweets133
  • Following839
  • Followers213
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Photo by Jamie Kuzich (@JantonKay)Photo by Jamie Kuzich (@JantonKay)Photo by Jamie Kuzich (@JantonKay)Photo by Jamie Kuzich (@JantonKay)Photo by Jamie Kuzich (@JantonKay)Photo by Jamie Kuzich (@JantonKay)
Jamie Kuzich retweeted
Arjun Raj (@arjunrajlab) profile picture
Arjun Raj
@arjunrajlabOct 21
All cell types are wrong, but some are useful.
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Jamie Kuzich retweeted
Mark Dawson (@MAF_Dawson) profile picture
Mark Dawson@MAF_DawsonJul 21
A labour of love!! Incredibly proud of Brian, @BalicJesse and so many in @TheDawsonLab who did a mountain of work. Grateful to all our collaborators. Thanks also to @maxvcg for a lovely N&V. nature.com/articles/s41588-0…
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry

Nature Genetics - This study uses a highly selective inhibitor to elucidate DNMT1’s specific functions and their regulation. Notably, RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA...

nature.com
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Jamie Kuzich retweeted
Itai Yanai (@ItaiYanai) profile picture
Itai Yanai
@ItaiYanaiApr 15
How does a cell learn? In our new perspective in @Nature we propose a model where the properties of the AP-1 family of transcription factors – stress-induced feedback, regulatory combinatorics & cellular memory – encode a mechanism for cellular learning. nature.com/articles/s41586-0…
Image from Itai Yanai (@ItaiYanai)
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Jamie Kuzich retweeted
Liz Brem, MD (@DrLizBrem) profile picture
Liz Brem, MD@DrLizBrem8 Dec 2024
Glofi+R-CHOP/R-polaCHP. I really like this study schema, allowed for short Dx to Tx interval to actually get a high risk group in study. #lymsm #ASH24
Image from Liz Brem, MD (@DrLizBrem)
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CART could have it ALL. Obe-cel results @NEJM: 👉127 pts 👉complete remission 55% 👉median event-free survival 12 months 👉1-year survival 65% 👉severe CRS/ICANS in 2% and 7% 👉survival curve plateau but limited follow-up 👉high tumor burden still a challenge Congrats @drclaireroddie @hemedoc and colleagues! nejm.org/doi/full/10.1056/NE…
Image from Nico Gagelmann (@NicoGagelmann)
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Bridging RT v systemic tx retrospective before axi-cel #ASH24: - 98 pts, 35 RT bridging alone - CR 85% RT, 71% chemo (not significant) - 1-yr PFS 75% RT, 49% chemo (significant) - MV model PFS: improved PFS (HR 0.41) with RT alone Time for a randomized trial. #lymsm
Image from Ajay Major, MD, MBA (@majorajay)
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Jamie Kuzich retweeted
Neil Renic (@NC_Renic) profile picture
Neil Renic@NC_Renic30 Oct 2024
7:30: Declare big day of writing 8:00-17:00: Fail to write 17:30: Declare big day of writing tomorrow
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Gonna get a tattoo on my chest that reads "just because a result is statistically significant does not mean it is biologically significant" & a matching tattoo on my back that reads "just because a result is biologically significant does not mean it is statistically significant"
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Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in @BloodJournal, we’ve discovered an intriguing mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL. Thread👇
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Dr Jamie Kuzich (@JantonKay) from @TheDawsonLab has received the @ASH_hematology 2024 Global #Research Award - one of just of 11 awarded to early career investigators from around the globe. Watch 👇Read more: petermac.org/about-us/news-a… #bloodcancer #hematology #haematology
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Last month, the Dawson Lab celebrated our 10th year in action! 🎉 It was a wonderful day of laughs, catching up, and reflecting on just how far we’ve come over the last decade. What a great looking group! See ya in 5 years! 🥂
Image from The Dawson Lab (@TheDawsonLab)
Image from The Dawson Lab (@TheDawsonLab)
Image from The Dawson Lab (@TheDawsonLab)
Image from The Dawson Lab (@TheDawsonLab)
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Image from Happy Researchers (@hapyresearchers)
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So good to finally see this out in all its glory. I remember @charles_bell92 first telling me about this system on the drive down to lab retreat in my first few weeks in the lab, and it was beautiful to see the story develop. Bravo, Charlie!
Charlie Bell (@charles_bell92) profile pictureCharlie Bell@charles_bell9220 May 2024
Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published nature.com/articles/s41588-0…
Comparative cofactor screens show the influence of transactivation domains and core promoters on...

Comparative cofactor screens show the influence of transactivation domains and core promoters on...

Nature Genetics - Systematic assessment of cofactor dependencies of nine transcription factors (TFs) and promoters finds that TFs use unique cofactor combinations to modulate distinct steps in...

nature.com
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Proud to see our paper describing BARtab and bartools, two integrated software tools for the analysis of synthetic cellular barcodes is now published @CellRepMethods! We hope the community finds this work useful. cell.com/cell-reports-method…
Analysis of synthetic cellular barcodes in the genome and transcriptome with BARtab and bartools

Analysis of synthetic cellular barcodes in the genome and transcriptome with BARtab and bartools

Cellular barcoding methods trace the lineage relationship of individual cells at population or single-cell resolution. Holze et al. describe BARtab, a Nextflow pipeline, and bartools, an R package,...

cell.com
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Jamie Kuzich retweeted
Mark Dawson (@MAF_Dawson) profile picture
Mark Dawson@MAF_Dawson25 Apr 2024
Our latest paper from ⁦@TheDawsonLab⁩ - huge congratulations to ⁦@HenriettaHolze⁩ & ⁦@DaneVass⁩ who led this work - hope the lineage tracing / barcoding community find this helpful cell.com/cell-reports-method…
Analysis of synthetic cellular barcodes in the genome and transcriptome with BARtab and bartools

Analysis of synthetic cellular barcodes in the genome and transcriptome with BARtab and bartools

Cellular barcoding methods trace the lineage relationship of individual cells at population or single-cell resolution. Holze et al. describe BARtab, a Nextflow pipeline, and bartools, an R package,...

cell.com
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Jamie Kuzich retweeted
Michael Fischbach (@mfgrp) profile picture
Michael Fischbach
@mfgrp11 Apr 2024
How to pick a problem. Today in @CellCellPress. 1/53 cell.com/cell/fulltext/S0092…
Problem choice and decision trees in science and engineering

Problem choice and decision trees in science and engineering

Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for...

cell.com
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When the results you've been excited about for 2 years turn out to be an artifact
Image from Oded Rechavi (@OdedRechavi)
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Stellar 2024 Lab retreat with the best people! Ready for the year ahead! ⭐️ #DawsonOpen🎾 #unitedinnovation #boundlessdiscovery #bigimpact
Image from The Dawson Lab (@TheDawsonLab)
Image from The Dawson Lab (@TheDawsonLab)
Image from The Dawson Lab (@TheDawsonLab)
Image from The Dawson Lab (@TheDawsonLab)
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What a PERFFect day to share our new preprint! With @tsion_abay #BobStickels @MerilTakizawa @ChaligneRonan and @Satpathology, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.1101/… 1/n
Transcript-specific enrichment enables profiling rare cell states via scRNA-seq

Transcript-specific enrichment enables profiling rare cell states via scRNA-seq

Single-cell genomics technologies have accelerated our understanding of cell-state heterogeneity in diverse contexts. Although single-cell RNA sequencing (scRNA-seq) identifies many rare populations...

biorxiv.org
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me on my way to annoy my lab mates instead of writing this abstract
Image from Elisa Granato (@Prokaryota)
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