Neurologist / Researcher, helped catch "The Memory Thief" (opioid-associated amnestic syndrome)/ Enthusiast of a good case report and the New York Yankees
Boston, MA
Joined July 2021
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It can take over a decade for early observations to be adopted into mainstream medical knowledge…
Excited to see @GreenJournal raising awareness of OAS w Teaching NeuroImage ~10 yr after our 1st reports
@AndrewKofke @francisdeng @lsaguirre
neurology.org/doi/full/10.12…
A nice abstract on a prototypical case of CHANTER syndrome from @SocietyHospMed @UNCMedCenter @UNC_SOM
shmabstracts.org/abstract/be…
Interesting report of CHANTER spectrum case w metabolic acidosis and ⬆️ lactate in 20 yo F assoc w gen anesthesia (including opioids)
Genetic testing w mitochondrial variant m.11232T > C in the MT-ND4 gene
sciencedirect.com/science/ar…… (abstract in English, article in Spanish)
Looks like interesting reading on opioids, hippocampus, and POCD 🔓
A new collaborative study by Baskin lab just published. Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats sciencedirect.com/science/ar… @OhioStateDHLRI
The great @ginapoe on her lab’s work on opioids and the locus coeruleus
How sleep disruption drives opiate addiction relapse:
"When animals withdraw from opiates, our sleep is terribly disturbed, and the amount of sleep disturbance predicts relapse behaviors."
"The locus coeruleus is covered with opiate receptors. Exogenous opiates really strongly bind these receptors and calm it down."
"If you long-term reduce the number of receptors, when you withdraw the exogenous opiates, there is not enough of your endogenous opiates to reoccupy those few receptors."
"The locus coeruleus has nothing to calm it down anymore. It just fires and fires and fires."
"Nobody likes to live in that high-stress state and they'll do anything to get back to normal."
Dr. Gina Poe on @hubermanlab
Jed Barash retweeted
How sleep disruption drives opiate addiction relapse:
"When animals withdraw from opiates, our sleep is terribly disturbed, and the amount of sleep disturbance predicts relapse behaviors."
"The locus coeruleus is covered with opiate receptors. Exogenous opiates really strongly bind these receptors and calm it down."
"If you long-term reduce the number of receptors, when you withdraw the exogenous opiates, there is not enough of your endogenous opiates to reoccupy those few receptors."
"The locus coeruleus has nothing to calm it down anymore. It just fires and fires and fires."
"Nobody likes to live in that high-stress state and they'll do anything to get back to normal."
Dr. Gina Poe on @hubermanlab
Wow 👀… a great graphic summary of opioid-associated amnestic syndrome (courtesy of Dr Javed Anees on LinkedIn)
🗣️ 2nd publication alert
New from Drug Alcohol Depend (🔓)
Those w opioid use disorder showed ⬇️ed hippocampal vols rel to controls w diffs strongest in post hippocampus
Congrats to Paul Regier @AndrewKofke @Miano81 @CorindeW @NIDAnews @PennMedicine
sciencedirect.com/science/ar…
🗣️New publication alert!
Recently published a comprehensive review of opioid-associated hippocampal injury
Amazing to see the progression of knowledge in this area over the past 10 years!
Appreciate co authors @josh_emncc and @AndrewKofke
onlinelibrary.wiley.com/doi/…
Early axonal injury in fentanyl intoxication: “β-amyloid and APP immunostains consistently revealed prominent axonal swellings, spheroids, and focal fragmentation, most pronounced in frontal white matter and hippocampus” @MeaghanOMorris @HopkinsMedicine
link.springer.com/article/10…
Jed Barash retweeted
NEWS: Opioid addiction linked to increased risk of dementia
The study lead by @Oxford_NDPH and @OxPsychiatry finds opioid addiction raises dementia risk by 56% compared with non‑users.
medsci.ox.ac.uk/news/opioid-…
“…findings together support Baló-like leukoencephalopathy likely triggered or exacerbated by chronic cocaine exposure…The temporal and geographic proximity of these cases… raises the possibility of a shared toxic exposure.”
@GreenJournal
neurology.org/doi/10.1212/WN…
Opioid-assoc hippocampal injury has become a staple of the @AANmember annual meeting abstracts
Here is an interesting case report from @TuftsMedSchool — including neuropath!
@joshuaak @SharanyaRamakr2 @SomaSen79612182 @schwetyk_md_phd @AndrewKofke
Jed Barash retweeted
A radiologist finally makes an appearance in the Pitt but gets one-upped by the med student going into psych who has never taken a radiology clerkship 🥲
Appreciate raising awareness of opioid-associated hippocampal injury, but
this report appears to represent evolution of CHANTER; opioid-associated amnestic syndrome (OAS) is an acute syndrome on the same spectrum — not CHANTER remnants
@francisdeng
sciencedirect.com/science/ar…
