Immunology lab @KingsCollegeLon working on B cells and mucosal immunology, led by Prof Jo Spencer
Joined September 2020
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Could tolerance to DNA be broken in the gut in systemic lupus erythematosus?
In our latest review we explore whether tolerance to DNA can be broken when undigested DNA from microbiota in GALT directly encounters B cells unrestricted by T cell dependence
doi.org/10.1016/j.imlet.2024…
Jo Spencer Lab retweeted
Immature B cell homing shapes human lymphoid tissue structure and function. A new Perspective by Jo Spencer & Chiara Dionisi @JoSpencerLab @KCLImmunoMicro hubs.la/Q02JSMGr0
Jo Spencer Lab retweeted
After leaving the bone marrow, transitional B cells split into subsets w/ biased expression of homing receptors and different surface IgM levels. Spencer & Dionisi @JoSpencerLab discuss how this could contribute to human lymphoid tissue content & function hubs.la/Q02JSNWX0
Our latest perspective piece is out now in @JExpMed! Here we propose that recruitment of immature B cells could contribute to human lymphoid tissue structure and function.
rupress.org/jem/article/221/…
Lots of amazing work on display at Spatial Biology Research @ King’s symposium, a pleasure for our postdoc @michaeljpitcher to showcase our work with the Spatial Biology Facility, using @nanostringtech CosMX to study B cells in gut lymphoid tissue
@KCLcancer_pharm @JelmarQuist
Jo Spencer Lab retweeted
Our latest paper is out now in @NatureComms!
Lucia Montorsi and @michaeljpitcher from our lab and collaborators identified characteristics of autoimmune diseases as normal components of the immune system in human gut:
nature.com/articles/s41467-0…
Jo Spencer Lab retweeted
Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity.
Check out this review by @BemarkMats & @jospencerlab in @TrendsImmuno #ASMicrobe hubs.li/Q02BRYMH0
Our latest paper is out now in @NatureComms!
Lucia Montorsi and @michaeljpitcher from our lab and collaborators identified characteristics of autoimmune diseases as normal components of the immune system in human gut:
nature.com/articles/s41467-0…
Huge thanks to our collaborators including @gibbonslab @fcicca @KCLImmunoMicro @KingsCollegeLon @GSTTresearch @BemarkMats and others
Normal functions of DN2 B cells, DNASE1L3 and C1q in the gut likely relate to bacterial recognition, bacterial killing and disposal of bacterial debris including DNA.
Failure of this system could result in persistence of bacterial DNA that could stimulate an autoimmune response
Big thanks to all our collaborators including @gibbonslab @BemarkMats @fcicca @GSTTresearch @gsttnhs @KCLImmunoMicro @KingsCollegeLon and others
Jo Spencer Lab retweeted
Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity dlvr.it/T39fjH #immunology
Jo Spencer Lab retweeted
Our review for Trends on the current knowledge of GALT is now out. We discuss its organisation, the role of GALT in B cell development, its role in autoimmunity and T cell help to B cells. Thanks to @JoSpencerLab and @michaeljpitcher for the collaboration. doi.org/10.1016/j.it.2024.01…
Our review of the current knowledge of GALT is out now in @TrendsImmuno ! In collab with @BemarkMats, we discuss GALT organisation, B/T cell interactions, responses to microbiota, and links between GALT and autoimmunity doi.org/10.1016/j.it.2024.01…
Jo Spencer Lab retweeted
Thank you so much Prof Jo Spencer @JoSpencerLab for a fascinating exploration of how #imc #imaging #masscytometry in tissue-based research can reveal surprising scientific findings...🔬🦠🧬🎆🫢
#tcell #GALT #autoimmunediseases #Lupus
@KCLImmunoMicro @ChokshiLab @DrAntonioRiva
Jo Spencer Lab retweeted
Delighted to say our latest paper has just come out
Huge thanks to all those involved eur03.safelinks.protection.o…