Find me at https://nitter.cf/t.co/MRvNBb4UpI
Joined July 2015
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I have decided to withdraw myself to posting research papers only on this website. Unfortunately, it has become neither enjoyable nor productive to be here. If you want, come and hang out, for example on bluesky: bsky.app/profile/jonathanboh…
Jonathan Bohlen retweeted
1/ We are delighted to share our work published in @SciImmunolgyidentifying the role of LY9 in CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis
(science.org/doi/10.1126/scii…)
Jonathan Bohlen retweeted
1/ I am excited to share our new paper from @casanova_lab published today in @JExpMed about humans with autosomal dominant IFNAR1 deficiency (doi.org/10.1084/jem.20241413).
Jonathan Bohlen retweeted
We reported recessive DBR1 deficiency underlying brainstem viral encephalitis in humans in 2018 (sciencedirect.com/science/ar…) then 2024 (rupress.org/jem/article/221/…). The molecular mechanism remained mysterious. Here it comes. Congrats to Daxing and team for the great findings!!!
Shuo Ru, Daxing Gao et al. show that the accumulation of RNA lariats in human DBR1-deficient cells impairs #StressGranule assembly–mediated PKR activation, and thereby cell-intrinsic antiviral immunity. hubs.la/Q02-zrTc0
@casanova_lab @ShenYingZhang1
#Immunodeficiency
Landmark paper from my colleague and friend Masato @casanova_lab ! A must read!!
1/ We report @ImmunityCP that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. cell.com/immunity/abstract/S…
Jonathan Bohlen retweeted
Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated #monocyte activation, reports @Jonathan_Bohlen and colleagues.
💬 More in @jclinicalinvest: bit.ly/3NEfh84
Jonathan Bohlen retweeted
Why do some patients with a CBL genotype develop autoinflammatory disease?jci.org/articles/view/181604
@Jonathan_Bohlen @casanova_lab and team report on chronic monocyte activation through the ERK pathway as a major contributor in patients with CBL LOF variants.
Wow, what an amazing experience this year's @ESIDsociety meeting was! A community driven by scientific curiosity and the motivation to help patients. It was a huge pleasure to present my work in front of this audience!
Jonathan Bohlen retweeted
A beautiful investigation into how germline heterozygous CBL variants lead to autoinflammation when accompanied by somatic loss of heterozygosity
I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/181604 1/8
Jonathan Bohlen retweeted
Germline + somatic CBL mutations in leukocytes result in autoinflammation. Great work led by @Jonathan_Bohlen !
I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/181604 1/8
Jonathan Bohlen retweeted
Congrats to my friend @Jonathan_Bohlen for another amazing story published! 🎉 Very happy to have had the chance to work with you on this project!
Check out the complete thread on human CBL deficiency 👇
I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/181604 1/8
Jonathan Bohlen retweeted
Excellent thread by @Jonathan_Bohlen about germline + somatic deficiency of CBL in leukocytes resulting in autoinflammation via dysregulation of monocytes !
I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/181604 1/8
Jonathan Bohlen retweeted
Autoinflammation in patients with leukocytic CBL loss of heterozygosity is caused by constitutive ERK-mediated monocyte activation @jclinicalinvest @casanova_lab @BustamanteJaci1 @Jonathan_Bohlen
jci.org/articles/view/181604
I’m excited to announce our new paper that came out today! The second chapter of my Post-doc @casanova_lab, published in @jclinicalinvest If you’re interested in the causes of autoinflammation, then this one is for you: jci.org/articles/view/181604 1/8
@ALNeehus Lucia Erazo-Borrás, Hailun Li, Zarah Janda, En-Jui Cho, Edoardo Muratore, Camille Soudée, Candice Lainé, Eric Delabesse, Claire Goulvestre, Cindy S Ma, @anne_puel @stutangye, Isabelle André,
Christine Bole-Feysot, Laurent Abel, Miriam Erlacher, @ShenYingZhang1
@BeziatV, Chantal Lagresle-Peyrou, Emmanuelle Six, @marlene_pasquet , @laiaalsina_, Alessandro Aiuti, @zhangpeng1202, @crow_lab, Nils landegren,Riccardo Masetti, Danny T. Huang, @casanova_lab and @BustamanteJaci1