Neuroscientist + medical student interested in neurodegenerative diseases, biomarkers and evidence-based medicine. 👨🍳 🚲 🎸🔬
Joined July 2020
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Joseph Therriault retweeted
Very happy to see this one finally out!!!
It's been wonderful to work on this together with the amazing @gesalbla! Thanks to all the co-authors at the University of Gothenburg, @biofinder_study and McGill University!
🚨New publication in @NatureAging🚨
Co-led between @MontoliuGaya and @gesalbla.
We measured several tau peptides in blood and assess their different relationships with Alzheimer’s disease stages.
nature.com/articles/s43587-0…
🧵
Also please see the accompanying commentary from Dr @AshviniKeshavan and Dr Alicia Algeciras-Schimnich :)
Plasma p-tau, particularly p-tau217, has the potential to revolutionise Alzheimer’s diagnosis; now we must prove it improves patient care and accelerates treatment access when used with a thorough clinical assessment - our comment in Lancet Neurology today thelancet.com/journals/laneu…
Joseph Therriault retweeted
Systematic review and meta-analysis: Therriault and colleagues evaluate the diagnostic performance of plasma p-tau biomarkers and individual p-tau assays to identify biologically defined Alzheimer's disease: thelancet.com/journals/laneu…
@JosephTherr
@pedrorosaneto
I’m proud to share our systematic review & meta-analysis of plasma p-tau diagnostic accuracy studies :)
thelancet.com/journals/laneu…
Some highlights:
Joseph Therriault retweeted
Do patients with rapidly progressive dementia (RPD) make you nervous? What signs and tests can help to make the right diagnosis expeditiously?
Our new paper explores these questions and more: doi.org/10.1002/ana.27297
With @PiuraYoav1 @nihalsatyadev @CorriveauNick + more!
Joseph Therriault retweeted
After more than 3 years of work, visualizing over 6,500 tau PET scans, and countless manuscript revisions, I still have to blink twice to believe it: our paper “Frequency and Clinical Outcomes Associated With Tau PET Positivity” is now published in JAMA.
jamanetwork.com/journals/jam…
Joseph Therriault retweeted
Congratulations to @JosephTherr and colleagues on their great work! The results of Alzheimer disease blood tests must be integrated with clinical data to understand the certainty of test results and formulate next clinical steps. #ENDALZ
nature.com/articles/s43587-0…
Joseph Therriault retweeted
Why the use of p-Tau217 needs to be integrated with clinical context for diagnosis or rule out of #Alzheimers disease
nature.com/articles/s43587-0… @NatureAging @JosephTherr
Joseph Therriault retweeted
Design paper on our multicenter tau PET study out in the same week that I scanned the first participant 💥 Now I know the work to set up a PET study 😅Many thanks to the team at @AlzheimerAms ! 🙏🏻🧠
Pleased to present the design paper of a Dutch multicenter study in which we aim to assess the clinical value of Tau PET, led by @vermeiren_marie (@AlzheimerAms).
"The impact of tau-PET in a selected memory
clinic cohort: rationale and design of the TAP-
TAU study"
Link to paper @AlzheimersRes: alzres.biomedcentral.com/art…
Joseph Therriault retweeted
Out now: our review on the challenges in the practical implementation of blood-based biomarkers for #Alzheimer’s
Big thanks to the wonderful Inge Verberk, Marta del Campo, Constance Delaby, @JosephTherr , Joyce Chong, @SebastianPalmqv and @DAlcoleaR
thelancet.com/journals/lanhl…
Joseph Therriault retweeted
And another amazing paper from my dear friend @LECollij
You're rocking it!
🚨New publication led by @LECollij ‼️
Lewy body pathology exacerbates brain hypometabolism and cognitive decline in Alzheimer’s disease” shows the exacerbating effects of a-synuclein co-pathology in Alzheimer's disease. Now published in @NatureComms !
nature.com/articles/s41467-0…
Joseph Therriault retweeted
The fact that Eisai refuses to release data on whether amyloid clearance correlates to cognitive benefits at the level of individual participants taking Lecanemab at this point can only mean one thing: that it clearly does not favorably correlate. #Alzheimers