LCGC International

This week on LCGC: a looming large-molecule chromatography expertise gap, 5 HPLC myths put to the test, & a preview of ChromSoc’s 2027 AI symposium. Catch up on the top stories➡️ hubs.li/Q04CW7sz0 #LCGC #Chromatography

Think you have to filter your mobile phase every time? Not necessarily. Michael Dong explains why in part 9 of his free HPLC video series. Watch it here 👉 hubs.li/Q04CTKvR0 #LCGC #HPLC

3 HPLC “rules” that aren’t as absolute as you think: 1. Mobile phase filtration isn’t always necessary 2. 4.6-mm columns aren’t a requirement, just a habit 3. AI helps more in late-stage optimization than early development Find out more ➡️ hubs.ly/Q04CQh550 #LCGC #HPLC

How do you pull one biologic cleanly out of a complex sample? David Hage & his team review over a century of affinity chromatography, from early enzyme purification to mAb & vaccine analysis today. Read more here➡️ hubs.li/Q04CLK2H0 #LCGC

What if headspace extraction didn’t mean one fiber per sample? Quantera Analytical’s Terry Bates breaks down the Curio HS, a cartridge-based platform extracting dozens of samples in parallel Find out more here➡️ hubs.li/Q04CF2Pk0 #Chromatography #SPME

Could AI ever replace a chromatographer? LCGC International asked Tony Edge, President of The Chromatographic Society, about ChromSoc’s new symposium, Data Analytics and AI in Chromatography, & why separation scientists should attend. More here ➡️ hubs.li/Q04CCSxJ0 #LCGC

Why does UV detection dominate pharmaceutical analysis and QC? Michael Dong answers in part 8 of his HPLC video series. 🎥 Watch the video: hubs.li/Q04CsfG10 #LCGC #HPLC

EU PFAS rules are shifting from individual compounds to the whole chemical class. Darina Dvořáková shares a tiered workflow for food testing labs. 🔬 See the strategy: hubs.li/Q04Cn9fR0 #LCGC #PFAS

Who’s going to fill chromatography’s expertise gap? 🧪 Amandaa Brewer of Arkema talks the future of large-molecule chromatography in Peaks & Pioneers. Watch her story➡️ hubs.li/Q04CgTVz0 #LCGC #Chromatography

Many steroids are nearly identical, and many carry no charge for MS to detect. Christopher Chouinard of Clemson explains how derivatization sharpens LC-IM-MS separations. 🔬 See how: hubs.li/Q04CgNN_0 #LCGC #MassSpectrometry

Is quantification, not instrumentation, what holds mass spec imaging back in food safety testing? This week: wastewater drug monitoring, siRNA methods, RAFA 2026 previews and more. 📚 Catch up: hubs.li/Q04C7Sl10 #LCGC #Chromatography

Your “100% Arabica” coffee might secretly have Robusta hiding in it. Nicolai Zederkopff Ballin breaks down how chromatography catches food fraud using maximum tolerable levels. Read here ➡️ hubs.li/Q04C7SRH0 #LCGC #FoodFraud

siRNA method development went from about two weeks to about three days. Ed Ahearne of AstraZeneca is using automation, ML and Bayesian optimization to go further. 🧬 See how: hubs.li/Q04BY-940 #LCGC #Chromatography

Acetonitrile or methanol, which one wins for your separation? Michael Dong compares their chromatographic properties in the latest installment. Watch it here: hubs.li/Q04BT_Q-0 #LCGC #HPLC

Can MSI show exactly where a contaminant sits inside food, without staining? Laura Righetti says yes, but quantification, not instrumentation, is still what keeps it out of routine food safety testing. Find out what else she thinks here: hubs.li/Q04BTpMG0 #LCGC #MassSpec

Nearly half of Australians aged 14+ have tried an illegal drug. Richard Bade and Malcolm McLeod explain how LC–MS/MS detects drug trends in wastewater. 🔬 See how it works: hubs.li/Q04BK0Ph0 #LCGC #Chromatography

Building an LC pressure troubleshooting app used to take coding skills. Dwight Stoll says LLMs have “obliterated” that barrier. 🛠️ See the free tool: hubs.ly/Q04BKT8b0 #LCGC #HPLC

Can AI really take over peptide method development? Piotr Alvarez says it could compress months of work into weeks, or even days, with software next running column & mobile-phase screening on its own. Watch here➡️ hubs.li/Q04BLHhx0 #LCGC #GLP1

What stands in the way of reversed-phase success in drug analysis? Michael Dong tackles it in part 5 of his HPLC video series. 🎥 Watch the video: hubs.li/Q04BxMtT0 #LCGC #HPLC

This week’s best of LCGC: greener affinity chromatography, AI and machine learning in separation science, GLP-1 peptide robustness, and food nontarget screening. 📚 Catch up on the top stories: hubs.li/Q04Bpf9l0 #LCGC #Chromatography