Entering our fourth decade: The next chapter of Liver Transplantation by @acv69cardenas @timucin_taner journals.lww.com/lt/citation…

Does one CT scan capture how muscle mass distorts MELD? Zheng et al. argue muscle loss in cirrhosis is dynamic and needs serial measures. Gupta et al. agree, and find no residual sex effect once muscle mass is considered. doi.org/10.1097/LVT.00000000… doi.org/10.1097/LVT.00000000… #LiverX

Is portal vein thrombosis more than a clot? In CLEARED, PVT carried higher 30-day mortality despite lower MELD-Na. This editorial argues PVT reflects structural disease of the portal vein, which may explain why anticoagulation often disappoints. doi.org/10.1097/LVT.00000000… #LiverX

Are livers from SARS-CoV-2-positive donors a thrombotic risk? In 102 recipients, HAT occurred in 4.9% and no donor or procurement factor predicted thrombosis. 1-year patient and graft survival were 96.1% and 94.1%, with no COVID-related deaths. doi.org/10.1097/LVT.00000000… #LiverX

Today 32 years ago, 19-year-old Maria Pedala in Sicily received the liver of 7-year-old Nicholas Green. Italy's donation rates then rose sharply. His father writes about donation advocacy & the #GiftOfLife it brought to her, her children and grandchild. 
doi.org/10.1097/LVT.00000000…

How transportable are ML-derived ascites phenotypes? A letter on Cullaro et al. notes that AKI hazard ratios (2.95 to 3.39) may be affected by censoring at LT, and that phenotype prevalence rose from 38.9% to 54.1% in a sicker validation cohort. doi.org/10.1097/LVT.00000000… #LiverX

Advanced hepatoblastoma: LR or LT? In 68 children with PRETEXT III–IV disease, 5-year survival was 88% after resection and 79% after LT. All deaths were disease-related, with most events in year 1. AFP response and metastases marked higher risk. doi.org/10.1097/LVT.00000000… #LiverX

Can alcohol use disorder care work after LT? In the Long-term Individualized Follow-up after Transplant (LIFT) Clinic 44% engaged in care. In the management track, 28% achieved sobriety and 60% reduced use. Engagement remained the key challenge. doi.org/10.1097/LVT.00000000… #LiverX

Does MELD overprioritize alcohol-associated hepatitis (AAH) for #LiverTransplantation? In UNOS 2018–2024, AAH had lower waitlist mortality but higher LT rates than other ALD. Below MELD 40, higher MELD was not associated with mortality in AAH. doi.org/10.1097/LVT.00000000… #LiverX

Why does portal vein thrombosis matter in hospitalized patients with cirrhosis? In the global CLEARED cohort investigating 7,721 patients across 37 countries, PVT affected 1 in 10 and was linked to more AKI, severe HE, and higher 30-day mortality. doi.org/10.1097/LVT.00000000… #LiverX

TIVA vs volatile #anesthesia in living donor hepatectomy: in 1,466 donor-recipient pairs, TIVA was associated with lower donor morbidity, fewer major complications, less blood loss and transfusions, with similar recipient outcomes. doi.org/10.1097/LVT.00000000… #LiverX #Perioperative

In children undergoing liver transplantation for biliary atresia, peri-transplant AKI occurred in 29%. Cirrhotic cardiomyopathy was common (61%) and independently associated with AKI (OR 6.6), pointing to a hepato-cardio-renal link. doi.org/10.1097/LVT.00000000… #LiverX #LiverFellows

Beyond graft survival: does health literacy matter after LT? In 1,042 LT recipients from the US #AllOfUs program, 36% had marginal health literacy. Higher BHLS scores were linked to better physical and mental health. A modifiable target for long-term care? doi.org/10.1097/LVT.00000000…

Do short LT wait times make waitlist mortality obsolete? SRTR argues no: pretransplant mortality captures risk-adjusted mortality before LT and complements transplant rate. Survival from listing is patient-centered, but component metrics remain important. doi.org/10.1097/LVT.00000000…

EDITORIAL 🔍 TIVA for living liver donors: signal or center effect? In 1,466 donors across 60 centers, volatile anesthesia was linked to more complications, including major morbidity (6.3% vs 1.2%). Strong signal, but causality still remains unproven. doi.org/10.1097/LVT.00000000…

From IRI to rejection and recurrent disease, graft injury is fundamentally spatial. Spatial omics can map the immune–stromal–parenchymal niches that shape injury, repair and graft fate and may open the door to precision transplant. doi.org/10.1097/LVT.00000000… #LiverX #LiverTwitter

🧒 Biliary complications remain the Achilles’ heel of pediatric LDLT. Among 2,665 recipients, bile leak (3.6%) and stricture (1.9%) were linked to worse graft survival. Donor BMI predicted leak; longer cold ischemia predicted stricture. 🔗 doi.org/10.1097/LVT.00000000…

#AI can sharpen prediction in liver allocation. But better prediction ≠ fairer allocation. This Perspective argues AI should support and not replace clinical judgment, with fairness monitoring, transparency & human oversight. doi.org/10.1097/LVT.00000000…

In HCC, social inequities may act before the waitlist. Among 576 LT referrals, high residential instability was linked to presentation beyond Milan and 4.7× higher psychosocial non-listing. Once listed, deprivation measures did not affect LT probability. doi.org/10.1097/LVT.00000000…

Can TAM & SALT-M guide LT selection in ACLF-3? In 336 recipients across 9 centers, high-risk thresholds identified ~10% with markedly worse 1-year survival, but overall discrimination remained modest (AUROC 0.61/0.64). Useful red flags, not gatekeepers. doi.org/10.1097/LVT.00000000…

Does one EAD definition fit all LDLT grafts? In 880 LDLTs, modified EAD predicted graft loss after right-lobe but not left-lobe grafts. Separate RL/LL day-7 risk scores markedly stratified graft-loss risk (HR 6.0 and 12.6). doi.org/10.1097/LVT.00000000…