Associate Professor in Cell Biology at UTSW, studying how organelles are shaped and organized
Dallas, TX
Joined August 2010
- Tweets528
- Following560
- Followers1.2K
- Likes1.1K
Jonathan Friedman retweeted
Thrilled to share our work "Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy" - a collaborative effort documenting the first cases of PPTC7 mutations in humans. 1/n
researchsquare.com/article/r…
Jonathan Friedman retweeted
Really thrilled to share our work on mitochondrial presequence strength @JCellBiol. We establish quantitative parameters to better define "strong" and "weak" presequences in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a grad student in my lab.
Youmian Yan, @IanofBristol, @nieminm et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. hubs.la/Q03-1x5l0
Jonathan Friedman retweeted
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @WashUBBSB graduate student Youmian Yan. A 🧵
biorxiv.org/content/10.1101/…
Jonathan Friedman retweeted
Important to celebrate trainee victories: excited to have @HollyMerta's paper out in @CellReports.
We use TurboID sub-organelle proteomics to map the ER network.
We discover calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility.
sciencedirect.com/science/ar…
Jonathan Friedman retweeted
If you are on UTSW campus May 16, please join us for the Lipid Metabolism & Neurodegenerative Disease mini-symposium! Many thanks to keynote speaker Dr. Hugo Bellen.
Jonathan Friedman retweeted
For #teamtomo, context is everything.
We highlight the power of #surfacemorphometrics in guiding STA and quantitatively assessing the impact of these structures on the local environment.
@benjaminbarad
Ya-Ting Chang, @nani_grotjahn et al. @scrippsresearch present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET hubs.la/Q039KqS80
Jonathan Friedman retweeted
Happy to announce I am serving as Director of the Lipid Metabolism & Neurodegenerative Diseases (LMND) Program at UTSW. Our goal is to stimulate collaborations bridging lipid metabolism & neurological disease.
So proud of our lab & their cell biology adventures! #onward_science
Jonathan Friedman retweeted
Edington et al. @labfriedman @UTSWMedCenter identify a mitochondrial inner membrane protein that marks and facilitates a subset of sites of mitochondrial fission in human cells. hubs.la/Q030B0yQ0
#Organelles #Mitochondria
Jonathan Friedman retweeted
Interested in BNIP3/NIX-mediated mitophagy? Check out our new review, written with @LabFriedman, about recent advances in the field and our thoughts on the regulation of these mitophagy receptors in space and time. doi.org/10.1042/BST20221364
Jonathan Friedman retweeted
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
biorxiv.org/content/10.1101/…
Jonathan Friedman retweeted
🚨 New paper alert from @martenssascha!🚨
We explore how transmembrane cargo receptors initiate selective autophagy. Through biochemical reconstitutions, we discover a new autophagosome biogenesis pathway with implications for therapeutic interventions.
biorxiv.org/content/10.1101/…
Jonathan Friedman retweeted
Really excited to share our latest paper describing the MitoLuc assay for quantitative mitochondrial protein import, which we wrote in collaboration with @IanofBristol! sciencedirect.com/science/ar…
Jonathan Friedman retweeted
Now curated in @PomBase pombase.org/reference/PMID:3…, thanks @LabFriedman ! Another #UnknownProtein down!
Very excited to share that our work identifying a new factor that works with MICOS to establish mitochondrial cristae architecture is now out @CurrentBiology!
cell.com/current-biology/ful…
Jonathan Friedman retweeted
I'm so excited to present my PhD work in this pre-print! We've discovered a novel population of mitochondria which are enriched for MICOS and MYO19 and traffic to the extreme periphery of cells.
New preprint from the lab! Amazing student @madeleinemarlar stumbled onto a very weird population of mitochondria in filopodia with a role in migration. They have very high levels of MICOS and myosin MYO19 at their tips that make them look like meteors! biorxiv.org/content/10.1101/…
Jonathan Friedman retweeted
Calling all microscopists! BioImaging North America is having their first STED User Group meeting tomorrow, June 13th at 11am CT. We have a really good turnout so far and would love to have even more people join! bioimagingnorthamerica.org/e…
Jonathan Friedman retweeted
Really excited to share some of our work in the @mito911_ series next Tuesday! See below for more details.
Jonathan Friedman retweeted
Beautiful and very important work by @LabFriedman on the discovery of a further DRP that participates in cristae morphology! A must read! LS
Very excited to share that our work identifying a new factor that works with MICOS to establish mitochondrial cristae architecture is now out @CurrentBiology!
cell.com/current-biology/ful…
Jonathan Friedman retweeted
Really nice new preprint from @LabFriedman and the amazing @TheMitotracker dissecting CCDC51 as a Mdm33 like inner membrane protein that demarcates mito fission events. Congrats!
Human CCDC51 and yeast Mdm33 are functionally conserved mitochondrial inner membrane proteins that demarcate a subset of organelle ... biorxiv.org/cgi/content/shor… #biorxiv_cellbio
Jonathan Friedman retweeted
Check out how awesome mitochondria look in fission yeast and join #pombeTalks Wednesday to hear new work from our postdoc @abhishek_mito with something for everyone: cristae, MICOS, and a weird dynamin pseudoenzyme.
Sign up/register here to attend: evonuclab.org/pombetalks
Jonathan Friedman retweeted
📢TOMORROW⬇️
📢In 1 week!
@mito911_ webinar "Spatial Regulation of Receptor-Mediated #Mitophagy"
by Dr. Jonathan Friedman @LabFriedman ⬇️
