Peng Jiang Lab

Well said on the role of somatic mutations in myeloid cells in Alzheimer's disease! (cell.com/trends/molecular-me…) The CSF2RB A455D variant from our study is also a promising example. More studies using chimeric brain models with human microglia carrying somatic mutations are needed.

An idea we started in 2019 is now published in @NatureNeuro! Excited to share our new study: rdcu.be/eRvdA Congrats to Mengmeng Jin @jin_mengmeng and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!

Happy to share our Spotlight in @CellStemCell on advances in microglia replacement therapy (Wu et al., Science; Mader et al., Nature) and our perspectives on resilience variants & microglia reprogramming to enhance the “engineering brain sentinels” approach for brain repair.

This review was actually written once before (the section on methodological considerations for creating chimeric models is shown👇）, but it didn’t make it to publication at the time.

I was inspired by Dr. Suchun Zhang’s work on differentiating human PSCs + transplanting them into mice, and Dr. Steven Goldman’s work on human oligodendroglia taking over mouse brains. We discussed the idea of chimeric models in our 2014 Nat Commun paper 👇

Thrilled to share our review just published in @NeuroCellPress! Big shoutout to Ava, Mengmeng , and our entire team! authors.elsevier.com/a/1k-uh…

Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks academic.oup.com/brain/advan…

We had a fantastic time in Chicago and thoroughly enjoyed the SfN meeting! #SfN24 #sfn2024

Microglia transplantation therapy for treating neurodegenerative conditions doi.org/10.1016/j.neuron.202… doi.org/10.1016/j.neuron.202… @NeuroCellPress

Hacking the immune system could slow ageing — here’s how nature.com/articles/d41586-0… But how to replace or rejuvenate the brain's immune cells, microglia? Hope our recent work can provide some clues.