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Reginato Lab

@LabReginato

Cancer biology lab @drexelmedicine focused on how signaling pathways regulate metabolic reprogramming in cancer cells.

 Philadelphia, PA
drexel.edu/medicine/faculty/profiles/mauricio-reginato/~/link.aspx?_id=5421231849C74ABE94DD3
Joined January 2020
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ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis aacrjournals.org/cancerres/a…
ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis

ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis

Targeting ACSS2 with brain penetrant inhibitors induces ferroptosis in brain metastatic breast cancer by perturbing an E2F1/SLC7A11 axis, providing an efficacious strategy for treating brain metast...

aacrjournals.org
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Happy to share recent work from our lab. ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis aacrjournals.org/cancerres/a…
ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis

ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis

Targeting ACSS2 with brain penetrant inhibitors induces ferroptosis in brain metastatic breast cancer by perturbing an E2F1/SLC7A11 axis, providing an efficacious strategy for treating brain metast...

aacrjournals.org
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Happy to share new Spotlight Review in @TrendsCellBio New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-C... sciencedirect.com/science/ar…
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Happy to share new publication on the role of OGT in regulating breast cancer stem cells led by former Biochemistry PhD student Giang Le Ming @GiangLeMinh2 and collaborator Lauren Ball at @MUSC_COM mdpi.com/3216500 #mdpicells via @Cells_MDPI
GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance

GATAD2B O-GlcNAcylation Regulates Breast Cancer Stem-like Potential and Drug Resistance

The growth of breast tumors is driven and controlled by a subpopulation of cancer cells resembling adult stem cells, which are called cancer stem-like cells (CSCs). In breast cancer, the function and...

mdpi.com
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Excited to share work started by Lorela Ciraku @loriciraku and completed by Emily Esquea @esqueaemily & Riley Young @_riley_young_ @DrexelMcbg & collaborators ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells biorxiv.org/content/10.1101/…
ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells

ACSS2 regulates ferroptosis in an E2F1-dependent manner in breast cancer brain metastatic cells

Brain metastasis diagnosis in breast cancer patients is considered an end-stage event. The median survival after diagnosis is measured in months, thus there is an urgent need to develop novel...

biorxiv.org
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Drexel @DrexelMCBG @Drexelmed PhD student Riley Young @_riley_young_ presented part of her thesis research as a short talk at @CSHL August 2024 Mechanisms and Models of Cancer Conference in Cold Spring Harbor, NY
Image from Reginato Lab (@LabReginato)
Image from Reginato Lab (@LabReginato)
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Congratulation to🥳Dr. Emily Esquea @esqueaemily who defended her PhD thesis last week #proudpi 🏆@drexelmcbg @Drexel_med_grad @DrexelMedicine
Image from Reginato Lab (@LabReginato)
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Reginato Lab retweeted
DrexelMCBG (@DrexelMcbg) profile picture
DrexelMCBG@DrexelMcbg17 May 2024
Big congrats to Emily 🎉 🎉 🎉 GRADUATE COLLEGE RESEARCH EXCELLENCE AWARDS - Expanding the Impact of Research 🧬 🧬 🧬 drexel.edu/graduatecollege/n… Emily Esquea, PhD Candidate Drexel @DrexelMcbg Program Mentor: Dr. Mauricio Reginato @LabReginato @DrexelBiochem @DrexelMedicine
Image from DrexelMCBG (@DrexelMcbg)
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Excited to share this new work by excellent graduate students @esqueaemily @loriciraku @_riley_young_ @DrexelMcbg @DrexelMedicine with collaborators @NickiSimone4 @mzspectrum frontiersin.org/journals/pha…
Frontiers | Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic...

Frontiers | Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic...

Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rel...

frontiersin.org
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Reginato Lab retweeted
DrexelMCBG (@DrexelMcbg) profile picture
DrexelMCBG@DrexelMcbg10 May 2024
Thesis Defense 🧬🧬🧬 Emily Esquea @esqueaemily @DrexelMcbg PhD Candidate Friday, June 7, 2024, 10:00 a.m. NCB, Geary A Targeting Metabolic Vulnerabilities in Breast Cancer Brain Metastatic Cells Mentor: Dr. Mauricio Reginato @LabReginato @DrexelBiochem @DrexelMedicine
Image from DrexelMCBG (@DrexelMcbg)
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Reginato Lab retweeted
DrexelMCBG (@DrexelMcbg) profile picture
DrexelMCBG@DrexelMcbg25 Apr 2024
Big congrats to Riley🧬🎉 @DrexelMcbg PhD Student Riley Young @LabReginato @DrexelBiochem @DrexelMedicine won the 1st Place for Best Trainee Short Talk Translational Cellular Oncology Retreat Sidney Kimmel Cancer Center Research Consortium @KimmelCancerCtr Well done Riley 🤩
Image from DrexelMCBG (@DrexelMcbg)
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The lab got a good news 🤩 Well done Kalisse @afrogenomics @DrexelMcbg 🎉 From the wall display monitor @DrexelBiochem @DrexelMedicine 😉 #BiomedicalSciences #AgingResearch #Geroscience #GraduateSchool
Image from Noguchi Laboratory (@NoguchiLab2004)
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Reginato Lab retweeted
DrexelMCBG (@DrexelMcbg) profile picture
DrexelMCBG@DrexelMcbg27 Feb 2024
MCBG Seminar 🧬🧬🧬 Thursday, March 7, 2024, 1 PM Dr. Christina M. Ferrer Assistant Professor Greenebaum Comprehensive Cancer Center University of Maryland @UMGCCC Identifying Tumor Cell Intrinsic and Microenvironmental Adaptations of Metastasis-Initiating Cells
Image from DrexelMCBG (@DrexelMcbg)
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Excited to host Dr. Cornelius Taabazuing @taabaman @BB_UPenn @PennMedicine for our department seminar series next Monday at 1 pm @DrexelMedicine
Image from Drexel Biochemistry & Molecular Biology (@DrexelBiochem)
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Looking forward to hosting Dr. Brian Capell @briancapell @PennEpiInst @PennCancer for our departmental seminar series next Monday @DrexelMedicine at 1 pm.
Image from Drexel Biochemistry & Molecular Biology (@DrexelBiochem)
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Congrats to Riley Young @DrexelMcbg PhD student, for being chosen as 2024 Community Engaged Research Training for Emerging Scientists trainee at @KimmelCancerCtr Riley will develop a cancer related community outreach initiative to promote engagement between SKCC & community
Image from Reginato Lab (@LabReginato)
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Congrats 🥳to PhD student Emily Esquea @esqueaemily @DrexelMcbg for receiving first prize 🥇for best trainee short talk at SKCC-Drexel Trainee Retreat #proudpi @KimmelCancerCtr @DrexelMedicine
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Online Now: Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation dlvr.it/T07Nqw #trends #endocrinology #metabolism
Image from Trends in Endocrinology & Metabolism (@Trends_Endo_Met)
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Fun to write a Spotlight Review for @Trends_Endo_Met on recent study in @Cell_Metabolism on role of fructose-mediated liver cancer via regulation of acetate and O-GlcNAcylation with @DrexelMcbg students @esqueaemily & @_riley_young_ authors.elsevier.com/a/1iFV%…
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