John Le Quesne (@LeQuesneLab) header
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Mazumdar-Shaw professor of molecular pathology, lung/pleura nut, multiplex imaging devotee, disciple of mRNA translation. #UoG #BICR #pathsoc 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇪🇺

Glasgow, Scotland
Joined March 2011
Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)Photo by John Le Quesne (@LeQuesneLab)
A lot of molecular and cell and developmental biology is concerned with figuring out the "functions" of various proteins. I'm starting to distrust that formulation...
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It was fantastic having the opportunity to speak at Worldcon 2024 about cancer, and its role as a metaphor in science fiction yesterday. Such a good experiemce - great audience and brilliant questions and discussions. @UofGlasgow @CRUK_SI #WorldCon
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John Le Quesne retweeted
Replying to @Molly_McKenzie2
@Molly_McKenzie2 has just published her first first-author publication! So much to know about NFkB signaling in this review! Enjoy! 🎉🎊
Really excited to share my first review article! Have a look if you are interested in NFkB signalling in colorectal cancer! 👩‍🔬 NFκB signalling in colorectal cancer: examining the central dogma of I... sciencedirect.com/science/ar…
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Only possible through amazing bioinf from Nicolas Poulain, next-level deep ohenotyping from Leah Officer-Jones and team (@AkoyaBio tech), and superb whole-transcriptome @nanostringtech GeoMx data from the @nigeljamieson group. FFPE rules! @UofGlasgow @CRUK_SI @unibern
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The last few days have been superb. It's been a real privilege to co-lead the TRANSLACORE biobanking training school with Neşe Atabey. The Izmir Biomedicine and Genome Centre have been amazing hosts. Three talks from the world of Scottish tissue research!
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Curious about AI's potential in Pathology? Discover how self-supervised AI autonomously learns histologic patterns: no need for experts to perform tedious annotations! Dive into our latest research: rdcu.be/dKtEp #PrecisionPathology @NYUGSOM_PMED @NYUGSOM_Path
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A fantastic collaboration with @Adalberto_Cq, Nicolas Coudray, @LeQuesneLab, @keyuan1, and more! @glasgowunisrc @nyugrossman
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A new AI-powered system developed by researchers at @GlasgowCS, @UofGCancerSci and @nyulangone can spot signs of cancer in samples with remarkable accuracy. It could help human pathologists and improve cancer care in the future. Read more: gla.ac/4bRl98v
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I’m so very proud of this work, with my CS colleagues in Glasgow and NYU. The pathology implications are HUGE. Self-learning AI for fully interpretable democratised quantitative H&E image analysis and accurate prognostication. gla.ac.uk/news/headline_1079…
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Crucial conclusions from MARS-2. Radical mesothelioma surgery does not extend life. #WCLC
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John Le Quesne retweeted
What AI can teach us about the nitty-gritty of patterns in pathology slides? We show that self-supervised learning can identify patterns that predict survival, have distinct molecular profiles, and most interestingly help pathologists find previously unappreciated clues.
🔬Our latest-preprint: self-supervised AI automating histologic pattern discovery and enhancing collaboration with pathologists. Check it out: arxiv.org/abs/2205.01931 with @Adalberto_Cq Nicolas Coudray @LeQuesneLab @keyuan1 et al.! #PrecisionPathology @NYUGSOM_Path @NYUGSOM_PMED
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🔬Our latest-preprint: self-supervised AI automating histologic pattern discovery and enhancing collaboration with pathologists. Check it out: arxiv.org/abs/2205.01931 with @Adalberto_Cq Nicolas Coudray @LeQuesneLab @keyuan1 et al.! #PrecisionPathology @NYUGSOM_Path @NYUGSOM_PMED
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Ermagerd. Xenium is alive. Straight out of the box it's UMAPing the hell out of control cells with an optimisation panel. Turns out there's diverse and interesting cell states even in tissue culture. Can't wait to start tackling real questions about tumour function. #10X #Xenium
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We had a day of team-building next week. Note to self- axes to be left outside the door in lab meetings.
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I mean last week. LAST WEEK.
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