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Life Medicine

@LifeMedJournal

Life Medicine is a fully open access, peer-reviewed journal that aims to accelerate the translation of life science research from bench to bedside.

 Oxford University Press
academic.oup.com/lifemedi
Joined August 2021
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CEBPA-induced trophectoderm-like cells from pluripotent stem cells enable modeling of trophoblast lineage specification doi.org/10.1093/lifemedi/lna…
CEBPA-induced trophectoderm-like cells from pluripotent stem cells enable modeling of trophoblast...

CEBPA-induced trophectoderm-like cells from pluripotent stem cells enable modeling of trophoblast...

Abstract. Trophoblast lineages are essential for placental development and play indispensable roles in mammalian development. However, the regulatory mecha

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A framework of biomarkers for skin aging: a consensus statement by the Aging Biomarker Consortium (ABC) doi.org/10.1093/lifemedi/lna…
A framework of biomarkers for skin aging: a consensus statement by the Aging Biomarker Consortium...

A framework of biomarkers for skin aging: a consensus statement by the Aging Biomarker Consortium...

Abstract. Skin is the largest organ of the human body and the first line of defense against the external environment. With the rapid growth of the older po

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Combined organ xenotransplantation: from graft function to cross-species homeostasis doi.org/10.1093/lifemedi/lna…
Combined organ xenotransplantation: from graft function to cross-species homeostasis

Combined organ xenotransplantation: from graft function to cross-species homeostasis

Combined organ xenotransplantation represents a new frontier beyond single-organ replacement, testing whether multiple porcine organs can be integrated int

academic.oup.com
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Mapping structural–immune crosstalk in asthma doi.org/10.1093/lifemedi/lna…
Mapping structural–immune crosstalk in asthma

Mapping structural–immune crosstalk in asthma

Lin Chen, Yu-Xuan Jin, Jin-Lyu Sun; Mapping structural–immune crosstalk in asthma, Life Medicine, , lnag036, https://doi.org/10.1093/lifemedi/lnag036

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Correction to 8 papers to correct the volume number doi.org/10.1093/lifemedi/lna…
Correction to 8 papers to correct the volume number

Correction to 8 papers to correct the volume number

This is a correction to the following 8 papers:

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Combined organ xenotransplantation: from graft function to cross-species homeostasis doi.org/10.1093/lifemedi/lna…
Combined organ xenotransplantation: from graft function to cross-species homeostasis

Combined organ xenotransplantation: from graft function to cross-species homeostasis

Combined organ xenotransplantation represents a new frontier beyond single-organ replacement, testing whether multiple porcine organs can be integrated int

academic.oup.com
1
14
Conserved NCoR1 Decline Underlies Small Intestinal Aging doi.org/10.1093/lifemedi/lna…
Conserved NCoR1 decline underlies small intestinal aging

Conserved NCoR1 decline underlies small intestinal aging

Defining the cellular and molecular basis of intestinal aging remains an important question in aging biology. The small intestine is a highly organized, co

academic.oup.com
8
Mapping structural–immune crosstalk in asthma doi.org/10.1093/lifemedi/lna…
Mapping structural–immune crosstalk in asthma

Mapping structural–immune crosstalk in asthma

Lin Chen, Yu-Xuan Jin, Jin-Lyu Sun; Mapping structural–immune crosstalk in asthma, Life Medicine, , lnag036, https://doi.org/10.1093/lifemedi/lnag036

academic.oup.com
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Decoding immunotherapy resistance in glioblastoma: mechanistic limitations, clinical trial failures, and strategic roadmaps for next-generation checkpoint modulation doi.org/10.1093/lifemedi/lna…
Decoding immunotherapy resistance in glioblastoma: mechanistic limitations, clinical trial failur...

Decoding immunotherapy resistance in glioblastoma: mechanistic limitations, clinical trial failur...

Abstract. Glioblastoma (GBM) remains one of the most treatment-refractory malignancies, characterized by profound intratumoral heterogeneity, an immunologi

academic.oup.com
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Brain region-specific lesions in the early AIDS monkey model doi.org/10.1093/lifemedi/lna…
Brain region-specific lesions in the early AIDS monkey model

Brain region-specific lesions in the early AIDS monkey model

Abstract. Brain lesions show pronounced regional heterogeneity during chronic or advanced human immunodeficiency virus (HIV) infection; however, the region

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Tumor cell-specific exon 3-deleted FOXP3 isoform promotes growth and metastasis via STAT3 in non-small cell lung cancer doi.org/10.1093/lifemedi/lna…
Tumor cell-specific exon 3-deleted FOXP3 isoform promotes growth and metastasis via STAT3 in...

Tumor cell-specific exon 3-deleted FOXP3 isoform promotes growth and metastasis via STAT3 in...

Abstract. Forkhead box P3 (FOXP3), the master regulator of regulatory T cells (Tregs), is aberrantly expressed in tumor cells, including lung cancer. Alter

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Connexins in metabolic control: linking brain cellular communication to systemic homeostasis doi.org/10.1093/lifemedi/lna…
Connexins in metabolic control: linking brain cellular communication to systemic homeostasis

Connexins in metabolic control: linking brain cellular communication to systemic homeostasis

Abstract. Connexins, a family of transmembrane proteins, are essential for intercellular communication in the mammalian central nervous system, particularl

academic.oup.com
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Bile acids as a “new hormone” in aging-related liver disease doi.org/10.1093/lifemedi/lna…
Bile acids as a “new hormone” in aging-related liver disease

Bile acids as a “new hormone” in aging-related liver disease

Abstract. Bile acids (BAs) have evolved from their classical definition as digestive surfactants to be recognized as potent endocrine signaling molecules t

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PLIN5-mediated lipid droplet-mitochondria contacts dysregulation underlies the increased susceptibility to acute kidney injury with aging doi.org/10.1093/lifemedi/lna…
PLIN5-mediated lipid droplet–mitochondria contacts dysregulation underlies the increased suscepti...

PLIN5-mediated lipid droplet–mitochondria contacts dysregulation underlies the increased suscepti...

Dear Editor,

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A Novel Framework for Studying Human Aging: Trophoblast Stem Cell–Syncytiotrophoblast Platform as a Physiologically Relevant and Accelerated Model of Cellular Aging doi.org/10.1093/lifemedi/lna…
A novel framework for studying human aging: trophoblast stem cell–syncytiotrophoblast platform as a...

A novel framework for studying human aging: trophoblast stem cell–syncytiotrophoblast platform as a...

While animal models and in vitro cellular systems have been extensively employed to investigate aging, leading to the identification of evolutionarily cons

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Cross-species metabolic profiling of follicular compartments in obesity doi.org/10.1093/lifemedi/lna…
Cross-species metabolic profiling of follicular compartments in obesity

Cross-species metabolic profiling of follicular compartments in obesity

Abstract. Impaired fertility in obese women is closely associated with disruptions in follicular microenvironment homeostasis. However, the underlying meta

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A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium doi.org/10.1093/lifemedi/lna…
A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium

A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium

Abstract. Renal aging involves structural and functional kidney decline (reduced size/nephrons, glomerulosclerosis, tubular atrophy, functional loss) and i

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Metabolic disorders and osteoarthritis: novel insights into pathological mechanisms and therapeutic strategies doi.org/10.1093/lifemedi/lna…
Metabolic disorders and osteoarthritis: novel insights into pathological mechanisms and therapeutic...

Metabolic disorders and osteoarthritis: novel insights into pathological mechanisms and therapeutic...

Abstract. Metabolic disorders and osteoarthritis (OA) are chronic noncommunicable diseases with high global prevalence. Accumulating evidence underscores a

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Most Picked Paper Collection 2025 academic.oup.com/lifemedi/pa…
Most Picked Paper Collection 2025

Most Picked Paper Collection 2025

This collection brings together diverse, high-impact papers published in 2025 that ranked as the most-viewed within the same year. All papers are selected accor

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Multimodal clocks of human aging cell.com/cell/abstract/S0092…
Multimodal clocks of human aging

Multimodal clocks of human aging

A multidimensional framework established to quantify human aging reveals highly conserved aging biomarkers and trajectories across multiple centers. By decoding the asynchrony of organ decline, the...

cell.com
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