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Renzo Luisi - Professor of Organic Chemistry #Uniba, Flow Chemistry, Organolithium Chemistry, Fluorinated Molecules, Heterocyclic Chemistry, Nitrogen Transfer

Bari, Puglia
Joined May 2018
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New paper out in Organic Letters! 🎉 Polar and e-radical strain-release strategies provide modular access to C1- and C4-functionalized OBHOs from bicyclo[1.1.0]butane carboxylic acids. A collaboration across Bari, Bologna & Sassari! pubs.acs.org/orlef7/article-…
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Super-strained spirocycles meet AI-supported target fishing. ⏹️🤝🎣 We introduce a new class of "super-strained" spirocycles which through AI-supported target fishing (@CASChemistry) were found to be agonists for the sigma-1 receptor. 💊 Now in @angew_chem Link in comments👇
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If strained spiro heterocycles have caught your attention, wait until you meet their "super-strained" counterparts. Full disclosure of results soon - stay tuned!! 🔜 @Luisi_Lab @SusPharma_eu
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🚀 @Luisi_Lab is supporting applications for a MSCA Fellowship! Join us to develop your own project with a strong focus on knowledge exchange in: 🔬 Flow chemistry | 💡 Photochemistry | 🤖 AI-driven drug discovery 📍 Bari, Italy 🌊☀️ 📩 Send your CV+project idea to @Luisi_Lab
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Luisi-Lab retweeted
Excited to share our Chem. Soc. Rev. paper on greener-by-design fine chemicals! 🌱🌱 A joint effort by Italian, German, British, Slovenian & Belgian teams. Congrats to PhD student Jonas Wuyts (ORSY) & all co-authors! pubs.rsc.org/en/content/arti… Check out the front cover!
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Luisi-Lab retweeted
🔬Modular access to spiro[2.3]hexanes! New sulfonium salts enable JCC-type reactions to build oxa- & diazaspiro[2.3]hexanes-rigid, sp³-rich bioisosteres. 🚀Supported by in silico prediction + in vitro validation by @Luisi_Lab - @angew_chem - Wiley Online Library onlinelibrary.wiley.com/doi/…
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📄New Preprint: We report a radical disconnection strategy that enables the direct, single-step, photocatalytic conversion of α-amino acids into differentiated vicinal diamines. Broad scope, functional-group tolerant, and scalable in flow. 🔗@ChemRxiv: chemrxiv.org/engage/chemrxiv…
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🔔Interested in strained spirocycles as potential bioisosteres? 🔔 Our recent @angew_chem describes our approach for the modular synthesis of spiro[2.3]hexanes and our in silico & in vitro investigation of their potential bioisosterism! @Luisi_Lab onlinelibrary.wiley.com/doi/…
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An interesting skeletal construction method published in Nature: nature.com/articles/s41586-0… A similar approach, published 75 years ago, still seems to be more convenient (although may be less tolerant): orgsyn.org/demo.aspx?prep=CV…
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After 50 years, radical chemistry returns to Italy! 🇮🇹 Bologna will host 𝗜𝗦𝗢𝗙𝗥-𝟭𝟰 (7–10 Jun 26), the international symposium on free radicals Cutting-edge science, world leaders, and unforgettable radical chemistry! 🔗isofr14.it #ISOFR14 #Chemistry #Radicals
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Just wrapped up JISOC2025 — the Japanese–Italian Symposium on Organic Chemistry 🇯🇵🤝🇮🇹 A huge honor to host outstanding Japanese and Italian scientists in Bari. Inspiring talks and posters all around! Thanks to all participants and the amazing @Luisi_Lab team! @farmuniba
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⭐️𝐓𝐡𝐫𝐢𝐥𝐥𝐞𝐝 𝐭𝐨 𝐩𝐫𝐞𝐬𝐞𝐧𝐭 𝐦𝐲 𝐟𝐢𝐫𝐬𝐭 𝐩𝐨𝐬𝐭𝐞𝐫 at the 𝐉𝐚𝐩𝐚𝐧𝐞𝐬𝐞–𝐈𝐭𝐚𝐥𝐢𝐚𝐧 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐨𝐧 𝐎𝐫𝐠𝐚𝐧𝐢𝐜 𝐂𝐡𝐞𝐦𝐢𝐬𝐭𝐫𝐲, and even more honored that it was awarded the 𝐁𝐞𝐬𝐭 𝐏𝐨𝐬𝐭𝐞𝐫 𝐏𝐫𝐢𝐳𝐞!🏆 @NathoPhilipp @JisocSymposium @Luisi_Lab
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It was very inspiring to attend the presentations given by such distinguished guest speakers at #JISOC2025: Prof. Keiji Maruoka (Kyoto University); Prof. Luisa De Cola (University of Milan); Prof. Yoshiaki Nishibayashi (Tokyo University) - part 1 @Luisi_Lab – at Bari, Apulia
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It was very inspiring to attend the presentations given by such distinguished guest speakers at #JISOC2025: Prof. Gianluca Farinola (University of Bari); Prof. Motomu Kanai (Tokyo University); Prof. Francesca Paradisi (University of Bern) - part 2 @Luisi_Lab – at Bari, Apulia
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It is a great honour that Prof. Mikiko Sodeoka is the first speaker at JISOC 2025, showing us the past, present and future prospects in late transition metal enolate chemistry! #JISOC2025 @Luisi_Lab – at Bari, Apulia
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Italy and Japan finally together: JISOC 2025 has begun in Bari! Prof. Renzo Luisi, Prof. Paolo Melchiorre, Prof. Gianluca Maria Farinola and Prof. Keiji Maruoka opened this unique event. @Luisi_Lab @SCIorganica – at Bari, Apulia
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European Researchers' Night 2025 Bari @MSCActions #ExpandFlow @Luisi_Lab
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