I'm the Mediator Complex but you can call me MED. I'm essential for gene transcription & my best friend is the RNA pol II. And I have a head, a body & a tail.
Joined September 2012
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TFs really like me too much
Excited to share a preprint on the structural mechanism of transcriptional activation by human Mediator, studied using integrative structural modeling.
Many thanks to Lacra Bintu @BintuLacra for helpful discussions!
biorxiv.org/content/10.64898…
@generegulation @MED_COMPLEX
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A mechanism of synergistic Mediator recruitment in RNA polymerase II transcription activation revealed by single-molecule fluorescence dlvr.it/TPB1Mt
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Inside @JbiolChem: New research sheds light on the fundamental mechanism of gene regulation by the Mediator complex.
➡️Read "N-terminal half of MED14 is critical for Mediator-RNA polymerase II interaction and the resulting transcription" here: jbc.org/article/S0021-9258(2….
ALT MED14-NTD is necessary for a full recovery of basal and activated (p53) transcription.
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It was a pleasure to present @cshlmeetings Mechanisms of Eukaryotic Transcription conference.
Watch my summary of how gene expression can be stopped using the link below. Thanks to the audiovisual team at @CSHL for recording.
lnkd.in/e5zxs24M
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Demonstration of the crucial role of MED14 in fetal #organogenesis and elucidation of the mechanistic details underlying a potential link between #VACTERLAssociation and the Mediator complex. #DiseaseModel
#OpenAccess: sciencedirect.com/science/ar…
MED13L Pathogenic Missense Variants Impair Protein Stability and Interaction, Underlying Diverse Clinical Outcomes
cell.com/hgg-advances/fullte…
Structural insights into human Pol III transcription initiation in action by @xu_lab #cryoem
nature.com/articles/s41586-0…
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Online Now: Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors dlvr.it/TL2Qrq
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We discussed how perturbing the Mediator Complex, a key gene expression regulator, reshaped cellular phenotypes. Some perturbations induced autonomous dedifferentiation, while others led to drug-resistant states. Interestingly, their effects aligned with the complex’s structure!
The first #cryoEM structure of a Mediator complex subunit in complex with a transactivation domain
nature.com/articles/s41467-0…
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What is the role of Med23 in brain development and ADHD pathophysiology?
Learn about the consequences of Med23 knockout and how methylphenidate may ameliorate the resulting ADHD-like behaviors
nature.com/articles/s41386-0…
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There is a new platform, Sci-Net (sci-net.xyz) where researchers can help each other by providing paywalled papers. The platform builds upon Sci-Hub meme token $scihub to reward active members.
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The basic helix-loop-helix transcription factor TCF4 recruits the Mediator Complex to activate gonadal genes and drive ovarian development biorxiv.org/content/10.1101/… #biorxiv_devbio
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We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their DNA targets. science.org/doi/10.1126/scie…
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A dual interaction between RSV NS1 and MED25 ACID domain reshapes antiviral responses biorxiv.org/cgi/content/shor… #biorxiv_pathol
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Real-time visualization of reconstituted transcription reveals RNA polymerase II activation mechanisms at single promoters biorxiv.org/cgi/content/shor… #biorxiv_biochem
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nature.com/articles/s41586-0…
(1/n) Ever wonder how transcription factors locate, "invade," and activate their enhancers during cell fate acquisition? 🧬🚀Check out our latest collaborative work with the Soufi lab, now published in @Nature!
