Mark Dodding (@MarkDodding) profile picture

Mark Dodding

@MarkDodding

Professor of Molecular Cell Biology at University of Bristol

 Bristol, England
markdodding.wixsite.com/doddinglab
Joined June 2010
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  • Following508
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Photo by Mark Dodding (@MarkDodding)Photo by Mark Dodding (@MarkDodding)Photo by Mark Dodding (@MarkDodding)Photo by Mark Dodding (@MarkDodding)Photo by Mark Dodding (@MarkDodding)Photo by Mark Dodding (@MarkDodding)
We have new preprint on biorxiv on kinesin-1 inhibition and activation. Collaborative effort across @BristolBiochem @BristolChem with @WoolfsonLab and Christiane Schaffitzel Lab with @ProteinMotion at U Exeter 1/2 biorxiv.org/content/10.1101/…
Molecular mechanism for cargo-mediated initiation of kinesin-1 activation

Molecular mechanism for cargo-mediated initiation of kinesin-1 activation

Kinesin-1 is a dynamic heterotetrameric assembly of two heavy and two light chains (KHC and KLC) that mediates microtubule-based intracellular transport of many different cargoes. The complex adopts...

biorxiv.org
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and a postdoc position working between our lab and @WoolfsonLab design proteins and peptides to augment kinesin-1 activity 2/2 jobs.ac.uk/job/DMN615/resear…
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We have a new 4-year postdoctoral position available working between our lab an the @WoolfsonLab @BristolBiochem @BristolChem applying protein design approaches to control intracellular transport. More info on flyer. Get in touch!
Image from Mark Dodding (@MarkDodding)
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Our paper explaining why two motor proteins that walk in opposite direction depend on each other is finally out. Great collaboration with @Carter_Lab, initiated by @zwetza, beautiful structural biology by @fe_aali. A thread 🧵 (1/9) nature.com/articles/s41594-0…
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We have three PhD projects with motor-cytoskeleton theme though collaborations with three new(ish) PIs at @BristolBiochem supported by @SWBio_DTP with Berni Carroll (lysosome transport), @fe_aali (endocytosis) and @jessica_a_cross (protein design) see swbio.ac.uk/biomolecular-and…
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Applications are now open for the Lister Prize 2025. Please apply by midnight (GMT) on Monday 23 September 2024. Start your application here: lister-institute.org.uk/how-…
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Our latest paper on actin within platelet microtubules led by @ChisatoTsuji is now in print. nature.com/articles/s41467-0… Where else might those little turduckens 🦃🦆 be hiding? @BristolBiochem @UoBrisPPN
CryoET reveals actin filaments within platelet microtubules

CryoET reveals actin filaments within platelet microtubules

Nature Communications - Using focused ion beam milling and cryoelectron tomography, Tsuji et al. found actin filaments, with both cofilin-bound and canonical morphologies, within the lumen of human...

nature.com
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A great collaboration with @Daniellempaul @HersIngeborg @PaulVerkade @alastair_poole labs with great support from @GW4CryoEM, funded by @wellcometrust @ListerInstitute @BBSRC and @TheBHF
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We're thrilled to announce 2024's brand new #ListerFellows! @DavidsnDeathLab @bcells_rosser @nickywhiffin @AlexBoRNA @theRAD_lab @SarahDimeloeLab welcome to the fold 🥳📷 🎈 lister-institute.org.uk/welc…
Image from The Lister Institute of Preventive Medicine (@ListerInstitute)
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Great to see our work on manipulating kinesin-1 activity using protein design led by @jessica_a_cross in print. In collaboration with @WoolfsonLab. @BristolBiochem @BristolChem @BrisBioDesign nature.com/articles/s41589-0…
A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1

A de novo designed coiled coil-based switch regulates the microtubule motor kinesin-1

Nature Chemical Biology - The kinesin-1 motor protein accesses open active and closed autoinhibited states. These states are regulated by a flexible elbow within a complex coiled-coil architecture....

nature.com
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Really interesting work from McKenney lab on actin-microtubule crosstalk mediated by kinesin-1 and Nesprin-2G biorxiv.org/content/10.1101/…
Active Microtubule-Actin Crosstalk Mediated by a Nesprin-2G-Kinesin Complex

Active Microtubule-Actin Crosstalk Mediated by a Nesprin-2G-Kinesin Complex

Nesprins are integral membrane proteins that physically couple the nucleus and cytoskeleton. Nesprin-2 Giant (N2G) stands out for its extensive cytoplasmic domain, which contains tandem N-terminal...

biorxiv.org
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We have two new faculty/group leader positions available at @BristolBiochem at Lecturer/Senior lecturer /Associate Professor levels. Links below. One with a broadly defined 'omics' remit and the other anything Biochemistry, Biophysics, Molecular Cell Biology or Syn Bio. Join us!
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jobs.ac.uk/job/DHE648/senior…
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Alexander Fellows, Andrew Carter et al @MRC_LMB show that individual #dynein motors can move the entire axon length during retrograde transport. In the anterograde direction, dynein & dynactin are transported separately, keeping them apart until required. hubs.la/Q02mfsKQ0
Image from Journal of Cell Biology (@JCellBiol)
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Mark Dodding retweeted
Carter Lab (@Carter_Lab) profile picture
Carter Lab@Carter_Lab6 Feb 2024
If you are interested in joining my group to study how microtubule motors select their cargos (or vice versa) then please see the two adverts below. One is based on neuronal cell biology, the other on reconstitution and cryoEM. nature.com/naturecareers/job… nature.com/naturecareers/job…
Postdoctoral Scientist - Structural Studies - Dr Andrew Carter - LMB 2344 - Cambridge, Cambridges...

Postdoctoral Scientist - Structural Studies - Dr Andrew Carter - LMB 2344 - Cambridge, Cambridges...

Postdoctoral Scientist Salary £39,375 per annum MRC Laboratory of Molecular Biology, Cambridge, UK An opportunity is available for a postdoctoral r...

nature.com
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This is great news to the see the work of our dear friend and colleague @David_S_Bristol recognised by the @RoyalMicroSoc Huge congratulations ! 🥳🥳🥳
RMS (@RoyalMicroSoc) profile pictureRMS
@RoyalMicroSoc5 Feb 2024
We are delighted to announce Professor David Stephens @David_S_Bristol as the latest recipient of the RMS Scientific Achievement Award! Many congratulations! 👏👏👏🔬🔬🔬 Read more: rms.org.uk/resource/professo…
Professor David Stephens, smiling, wearing glasses and purple top, against blue background.

ALT Professor David Stephens, smiling, wearing glasses and purple top, against blue background.

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The last of my PhD work is finally out in @NatureComms 🥳 after a huge team effort over several years! Thanks and congrats to all fantastic co-authors @emilyjglover1 @MitoPereira_GC @MarkDodding @IanofBristol (who led the show!), Alina Witt, Wolfgang Hübner, and Jeremy Henley!
Ian Collinson (@IanofBristol) profile pictureIan Collinson@IanofBristol2 Feb 2024
Bravo! @hopeneeds –final instalment of her trilogy of #mitochondria papers @BristolBiochem Massive effort also with @emilyjglover1 (check her pic!) @MitoPereira_GC Alina Witt, Wolfgang Hübner, @MarkDodding & Jeremy Henley Funded by @wellcometrust & @BBSRC rdcu.be/dxCzS
Image from Ian Collinson (@IanofBristol)
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Bravo! @hopeneeds –final instalment of her trilogy of #mitochondria papers @BristolBiochem Massive effort also with @emilyjglover1 (check her pic!) @MitoPereira_GC Alina Witt, Wolfgang Hübner, @MarkDodding & Jeremy Henley Funded by @wellcometrust & @BBSRC rdcu.be/dxCzS
Image from Ian Collinson (@IanofBristol)
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We're recruiting! Come and join us! @BristolBiochem is looking to appoint a Senior Lecturer/Associate Professor in Molecular Cell Biology. jobs.ac.uk/job/DFR887/senior…
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