Mehl lab (@Mehl_lab) header
Mehl lab (@Mehl_lab) profile picture

Mehl lab

@Mehl_lab

The Mehl Lab develops genetic code expansion to site-specifically incorporate non-canonical amino acids (ncAAs) into proteins. (Twitter run by students)

 Corvallis, OR
mehl.biochem.oregonstate.edu/
Joined June 2019
  • Tweets46
  • Following112
  • Followers195
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Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)Photo by Mehl lab (@Mehl_lab)
Mehl lab member, Cat Vesely, has arrived at ASMS! She's excited to share her work at the @GCEcenter and in collaboration with @Agilent
Image from Mehl lab (@Mehl_lab)
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We promise a good time! Looking forward to connecting with the GCE community!
Abhishek Chatterjee (@AChemSynBio) profile pictureAbhishek Chatterjee@AChemSynBio25 Apr 2024
🚨🚨All genetic code expansion enthusiasts, don’t miss the GCE 2024 conference this summer (gceconferences.org/)! Fantastic speakers both from academia and industry. Please retweet! @klanglab @Mehl_lab
Image from Abhishek Chatterjee (@AChemSynBio)
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Check out our latest paper! Congrats on this amazing work @ZhuChemBio!
ACS Central Science (@ACSCentSci) profile pictureACS Central Science@ACSCentSci15 May 2023
An autonomous E. coli system to genetically encode a functional nonhydrolyzable phosphoserine mimic into proteins is created and used to reveal how 14-3-3 phosphorylation rewires its interactome. NEW #ASAP by Richard Cooley & team at @OregonStateBB Read: go.acs.org/4Ra
Image from ACS Central Science (@ACSCentSci)
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Join us this Thursday, May 18th for our International GCE Webinar to hear talks from Sharona Gordon (@ProfSharona) & James Petersson (@EJPLab) 10 am ET/2 pm GMT. Register now!! oregonstate.zoom.us/webinar/…
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Happy #DamProudDay! Our department is raising funds for two $2,000 research fellowships, two $500 need-based scholarships, and to take a group of undergrad students to the National Diversity in STEM conference Oct. We appreciate any and all support! damproudday.org/campaigns/bi…
Image from Mehl lab (@Mehl_lab)
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Can't wait!!
GCE4ALL Research Center (@GCEcenter) profile pictureGCE4ALL Research Center@GCEcenter19 Apr 2023
We're excited to announce that we'll be hosting a 5 day intensive in-person workshop, Bioorthogonal Ligations - Clicking with GCE on Aug 8-12th 2023 in Corvallis OR. Open to all levels! Apply now! gceworkshops.org/
Image from GCE4ALL Research Center (@GCEcenter)
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Join us tomorrow, April 20th for our International GCE Webinar to hear talks from Andrea Cochran and Jeff Tharp (@jeffery_tharp) 10 am ET/2 pm GMT. Register now!! gce4all.oregonstate.edu/tool…
International GCE Webinar | GCE4All

International GCE Webinar | GCE4All

gce4all.oregonstate.edu
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Happy to share my major thesis project is officially online! Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3ζ pubs.acs.org/doi/10.1021/acs… #chemicalbiology #biochemistry #proteins
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Our latest publication on 14-3-3 protein tyrosine nitration is out now in Protein Science @ProteinSociety. Great job @ZhuChemBio and team!! Great structures with near-atomic detail to look at fine-tuned structural changes.
Phillip (Phil) Zhu (@ZhuChemBio) profile picturePhillip (Phil) Zhu@ZhuChemBio1 Feb 2023
14-3-3s are such cool proteins, and still have ambiguous function given how many other proteins they interact with. If you like PTMs, too check out my latest pub in @ProteinSociety journal Protein Science! These were my first structures ever solved! doi.org/10.1002/pro.4574
Genetic encoding of 3‐nitro‐tyrosine reveals the impacts of 14‐3‐3 nitration on client binding and...

Genetic encoding of 3‐nitro‐tyrosine reveals the impacts of 14‐3‐3 nitration on client binding and...

PDB Code(s): 8EQ8 and 8EQH;

onlinelibrary.wiley.com
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Our pre-print on 14-3-3 oxidative stress and how it alters 14-3-3 protein structure and function is out now. A really great vignette on utilizing 2 GCE systems to tackle 1 biological problem.
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint12 Nov 2022
Genetic encoding of 3-nitro-tyrosine reveals the impacts of 14-3-3 nitration on client binding and dephosphorylation biorxiv.org/cgi/content/shor… #bioRxiv
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Congratulations to all the poster winners and our graduate student @ZhuChemBio for winning the poster prizes at the latest PS36 @ProteinSociety!
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We're hiring! We currently have an opening for a Faculty Research Assistant- see the posting for details! jobs.oregonstate.edu/posting…
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Hey ya'll, I am looking for post doctoral work!! (finally) If you have any leads please let me know. Looking for structural biology, biochemistry postdocs. My linked in is here: linkedin.com/in/zhuph Thank you in advance!!

Phillip Zhu, PhD - Mountlake Terrace, Washington, United States | Professional Profile | LinkedIn

At OHSU, I used cryoEM to elucidate the structures gap junctions and KATP channels in… · Experience: Oregon Health & Science University · Education: Oregon State University · Location: Mountlake...

linkedin.com
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Check out our latest paper in @ScienceAdvances where we create designer tetrazine-based anti SARS-Cov nanobody conjugations with very interesting results! When it comes to nanobody conjugation, control is key. #nanobody #chembio science.org/doi/10.1126/scia…
Nanobody assemblies with fully flexible topology enabled by genetically encoded tetrazine amino...

Nanobody assemblies with fully flexible topology enabled by genetically encoded tetrazine amino...

An approach to varying the topology of nanobody assembly holds promise for creating more potent therapeutics and tools.

science.org
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New Research: Creating a Selective Nanobody Against 3-Nitrotyrosine Containing Proteins: A critical step in developing therapeutics for oxidative stress-related pathologies is the ability to determine which specific modified protein species… frontiersin.org/articles/10.… #chemistry
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Check out the news on the new NIH Funded GCE4ALL Research Center @OSUScience @Mehl_lab @RyanAMehl1 #GCE4ALL #geneticcodeexpansion kval.com/news/local/osu-rece…
OSU receives $5.6 million for new center to study protein engineering

OSU receives $5.6 million for new center to study protein engineering

Oregon State University has received $5. 6 million to study protein engineering, which is a prominent tool in fighting diseases. The money will allow the university to launch a research center...

kval.com
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Check out our new #NIHfunded center#GCE4ALL : gce4all.oregonstate.edu Congrats @RyanAMehl1 @Mehl_lab

Genetic Code Expansion (GCE) Technology for All | GCE4All

gce4all.oregonstate.edu
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A big congratulations to the newly minted Dr. Van Fossen who successfully defended her Ph. D yesterday morning! @FossenElise from the Mehl Lab. We are all so proud!
Image from Mehl lab (@Mehl_lab)
Image from Mehl lab (@Mehl_lab)
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Check out our latest preprint on the design and application of a 21 amino acid organism which synthesizes and encodes the non-hydrolyzable analog of phosphoserine! @ZhuChemBio #chembio #syntheticbiology #biochemistry #biochem
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint23 Oct 2021
PermaPhosSer: autonomous synthesis of functional, permanently phosphorylated proteins biorxiv.org/cgi/content/shor… #bioRxiv
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Latest findings from The Lueck Lab. Suppressor tRNAs work on endogenous CF causing nonsense mutations #nonsense #tRNAs biorxiv.org/content/10.1101/…
Efficient Suppression of Endogenous CFTR Nonsense Mutations Using Anticodon Engineered Transfer RNAs

Efficient Suppression of Endogenous CFTR Nonsense Mutations Using Anticodon Engineered Transfer RNAs

Nonsense mutations or premature termination codons (PTCs) comprise ∼11% of all genetic lesions, which result in over 7,000 distinct genetic diseases. Due to their outsized impact on human health,...

biorxiv.org
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