Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect) header
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Methyl Detect ApS | Epigenetics & MS-HRM

@MethylDetect

AU spin-off founded by Prof. T. Wojdacz & Prof. L. L. Hansen. Ready-to-use MS-HRM assays for epigenetic research. For Research Use Only. 🔬🧬

 Denmark
methyldetect.com/
Joined February 2017
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  • Followers312
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Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)Photo by Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)
Research Highlight: Schwartz et al. (2025) used Methyl Detect’s EpiMelt MD-BRCA1 assay to study early-onset TNBC. BRCA1 epimutations were detected in 33.9% of eligible patients aged ≤30. doi.org/10.1186/s13148-025-0… #BRCA1 #Epigenetics #TNBC
High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative...

High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative...

Clinical Epigenetics - Between 5 and 8% of the general population carry a constitutional methylation of the BRCA1 promoter (“epimutation”). Several studies have suggested that these...

link.springer.com
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Research Highlight: A 2022 JAMA Oncology study by Lønning et al. examining large cohorts linked constitutional BRCA1 methylation to TNBC and ovarian cancer risk. Read: doi.org/10.1001/jamaoncol.20… #BRCA1 #Epigenetics #CancerResearch
Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade...

Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade...

This case-control study examines the potential association between white blood cell BRCA1 promoter methylation and subsequent risk of incident triple-negative breast cancer and high-grade serous...

jamanetwork.com
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Methyl Detect Update: We have streamlined our portfolio to focus on core EpiMelt products, now manufactured under ISO 13485:2016 certification. Visit our website for all current product and pricing information. #MethylDetect #Epigenetics #MolecularDiagnostics
Just putting the final touches on everything with a nice view of the garden...

ALT Just putting the final touches on everything with a nice view of the garden...

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Current product information and pricing are available here: methyldetect.com/
Methyl Detect ApS | Epigenetics & MS-HRM

Methyl Detect ApS | Epigenetics & MS-HRM

Ready-to-use MS-HRM DNA methylation assays, bisulfite modification kits, and real-time PCR master mixes for translational & clinical research.

methyldetect.com
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🚨Just published in Clinical Epigenetics! 1 in 3 women ≤30 with triple-negative breast cancer (TNBC) carry a hidden BRCA1 epimutation — missed by genetic tests. 🧬 Detected with MethylDetect™ MS-HRM. 👉 doi.org/10.1186/s13148-025-0… #BRCA1 #Epigenetics #TNBC #MethylDetect
Image from Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)
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A new protocol featuring our assays published: High-sensitivity Epimutations Testing with MS-HRM #cancer #BRCA1 #prevention #epigenetics #breastcancer #detection #epimutation #epimelt #prediposition pubmed.ncbi.nlm.nih.gov/3992…
Image from Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)
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Constitutional BRCA1 Epimutations: A Key for Understanding Basal‐Like Breast and High‐Grade Serous Ovarian Cancer - Lønning - 2024 - Human Mutation - Wiley Online Library onlinelibrary.wiley.com/doi/…
Constitutional BRCA1 Epimutations: A Key for Understanding Basal‐Like Breast and High‐Grade Serous...

Constitutional BRCA1 Epimutations: A Key for Understanding Basal‐Like Breast and High‐Grade Serous...

Germline pathogenic genetic variants in the BRCA1 and BRCA2 genes are the most frequent causes of familial breast and ovarian cancer. Contrasting BRCA2, epimutations in the BRCA1 gene are frequently...

onlinelibrary.wiley.com
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The evidence for the significance of detectable in blood constitutional #BRCA1 #epimutation in #breastcancer #pathology 📑 🧾 in mounting Our MS-HRM assay can detect this epimutation in single PCR run 🧪 🥼 #epigenetics #cancer #cancerresearch #TNBC genomemedicine.biomedcentral…
Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development

Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development

Genome Medicine - Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as...

link.springer.com
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This landmark publication confirms that #EPImutation of #BRCA1 #gene is a risk factor for #breastcancer and #ovariancancer, but far more frequent than BRCA1 germline (!) #epigenetics #DNAmethylation #Oncology #mutation.jamanetwork.com/journals/jam…
Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade...

Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade...

This case-control study examines the potential association between white blood cell BRCA1 promoter methylation and subsequent risk of incident triple-negative breast cancer and high-grade serous...

jamanetwork.com
64
Superior performance of our #BRCA1 MS-HRM assay in detection of low level #constitutional #methylation in blood, over #methylation #microarrays for details see publication: #epigenetics #BreastCancer #CancerResearch nature.com/articles/s41598-0…
Analytical sensitivity of a method is critical in detection of low-level BRCA1 constitutional...

Analytical sensitivity of a method is critical in detection of low-level BRCA1 constitutional...

Scientific Reports - Analytical sensitivity of a method is critical in detection of low-level BRCA1 constitutional epimutation

nature.com
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We have today updated our website with new products for methylation research, visit: methyldetect.com for details :-) #MSHRM #epigenetics #DNAmethylation #bisulfitemodyfication
Image from Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)
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We are happy to announce publication of our application note in collaboration with Enzo Life Sciences, Inc. @EnzoLifeSci #epigenetics #biomarkers #epimelt #dnamethylation enzolifesciences.com/about-u…
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#brca1 #methylation detectable in blood is a potential breast and ovarian cancer risk factor, see also: #EpiMelthBRCA1 kit methyldetect.com/product/epi… pubmed.ncbi.nlm.nih.gov/3607…
EpiMelt BRCA1 Methylation Assay | MS-HRM Kit

EpiMelt BRCA1 Methylation Assay | MS-HRM Kit

EpiMelt BRCA1 methylation assay provides sensitive, pre-validated MS-HRM analysis with controls included. Request a quote from MethylDetect.

methyldetect.com
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linkedin.com/posts/methyldet…

BRCA1 and MGMT EpiMelth Assays woking to fight cancer 💪 💪 💪 poster presentations at Gliwice...

BRCA1 and MGMT EpiMelth Assays woking to fight cancer 💪 💪 💪 poster presentations at Gliwice Scientific Meeting 2022.

linkedin.com
Epigenetics and Epigenomics in Health and Disease PMF Brussels 2020 precisionmedicineforum.com/o…
Silencing of the MGMT gene by promoter methylation results in decreased MGMT protein expression and thereby reduced DNA repair activity. This will potentially increase the sensitivity of the tumor cell to chemotherapy.
Image from Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)
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Epigenetics and Epigenomics in Health and Disease PMF Brussels 2020 precisionmedicineforum.com/o…
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Just published a method for automated analysis of #methylation #epigenetics data #PCR #diagnostics Methylation levels assessment with Methylation-Sensitive High-Resolution Melting (MS-HRM) pubmed.ncbi.nlm.nih.gov/3606…
Methylation levels assessment with Methylation-Sensitive High-Resolution Melting (MS-HRM) - PubMed

Methylation levels assessment with Methylation-Sensitive High-Resolution Melting (MS-HRM) - PubMed

Testing for disease-related DNA methylation changes provides clinically relevant information in personalized patient care. Methylation-Sensitive High-Resolution Melting (MS-HRM) is a method used for...

pubmed.ncbi.nlm.nih.gov
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We can design #methylation #EpiMelt Assay to your region of interest for more info ask [email protected] , #methyldetect #epigenetics #cro #diagnostics #molecularbiology #moleculardiagnostics
Image from Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)
Meet our EpiMelt MLH1 methylation testing assay #methylation #epigenetics #diagnostics #cancer #lynchsyndrome #ivd
Image from Methyl Detect ApS | Epigenetics & MS-HRM (@MethylDetect)
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