Navigating the ever-growing Midwest startup ecosystem. Visit our site for job listings, startup + VC news, newsletter and our talent network. Powered by @M25vc.
Midwest, USA
Joined May 2017
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🚨 The #BestofMidwest2025 Startup City Rankings are here!
We analyzed 25 weighted variables across 50+ cities to see which ecosystems are thriving—and which have some work to do. 🧵
Chicago-based @SNAKVC announced a $50M FI.
They will back early-stage vertical B2B marketplaces digitizing industries like construction, logistics and industrial—sectors still operating on analog workflows that are ready for technology-driven platforms.
techcrunch.com/2026/02/04/sn…
📣 Entravia
📍 Minneapolis, MN
🗂️ HR / PEO
💰 Pre-seed round led by @M25vc with participation from Cambrian
midweststartups.medium.com/e…
Chicago-based Ariel Project Level announced a $250M fund.
Launched by Ariel Investments, the fund aims to capitalize on the continued growth of women’s sports across fandom, viewership and media coverage.
bizjournals.com/chicago/news…
What's new on the #MidwestStartups job board?
✉️ Customer Enablement Specialist - @useworkshop
🏡 Senior Loan Officer - @KIN
🚗 Marketing Operations Analyst - @SuperDispatch
Find more of the latest opportunities here:
jobs.midweststartups.com/job…
📣 @WhenInsurance
📍 Chicago, IL
🛡️ Insurtech
💰 $10.2M Series A co-led by @ManchStoryGrp and @7wireventures
axios.com/pro/health-tech-de…
📣 @opendate_app
📍 Indianapolis, IN
📆 Event Management
💰 $14M Series A led by @highalpha .
opendate.io/post/opendate-ra…
Chicago-based @treatmyocd has acquired Rebound Health for an undisclosed amount:
businesswire.com/news/home/2…
Columbia, MO-based @EquipmentShare has IPO'd.
Their Class A common stock has begun trading on the Nasdaq Global Select Market under the ticker symbol “EQPT.”
equipmentshare.com/press-rel…
📣 Zarminali Pediatrics
📍 Chicago, IL
🩺 HealthTech
💰 $110M Series A led by Healthier Capital
axios.com/pro/health-tech-de…
📣 Trailhead Biosystems
📍 Cleveland, OH
🔬 BioTech
💰 $20M in additional funding led by MAK Capital
prnewswire.com/news-releases…
Chicago-based @obieinsurance has been acquired by The Baldwin Group for an undisclosed amount:
businesswire.com/news/home/2…
It's newsletter week! 📰
Looking for funding announcements, upcoming tech events and a few of the latest job opportunities from across the Midwest? Join the #MidwestStartups mailing list!
Get subscribed: midweststartups.beehiiv.com/
What's new on the #MidwestStartups job board this week?
jobs.midweststartups.com/job…
✉️ Director of Marketing - @useworkshop
🧑⚕️ Director, Account Management - @steadymd
🏡 Staff Software Engineer - @KIN
📣 Onsetto
📍 Minneapolis, MN
📈 FinTech
💰 $2.2M Seed led by EJF Capital
tradingview.com/news/eqs:d58…
📣 @BioReact_US
📍 Indianapolis, IN
🔬 BioTech
💰 $1.07M Pre-Seed led by @NewStackVC
bioreact.co/blog/bioreact-pr…
📣 @CHAMPtitles
📍 Cleveland, OH
⚙️ Software / Transportation
💰 $55M round led by @WRBerkleyCorp, @p72vc and ORIX Corporation USA
businesswire.com/news/home/2…
If one of your resolutions is staying plugged into the Midwest startup scene, we’ve got you covered. Funding, VC updates, jobs and events every other Thursday.
midweststartups.beehiiv.com/
Looking for a new role in 2026? Join the #MidwestStartups talent network and find roles from 90+ Midwest-based companies.
jobs.midweststartups.com/tal…
A few of the latest roles from the #MidwestStartups job board:
jobs.midweststartups.com/job…
✉️ Accounting Manager - @useworkshop
📊 AI Audit Specialist - Stealth
👐 Recruiter - @Carefeed_
📣 Alphyn Biologics, Inc.
📍 Cincinnati, OH + Annapolis, MD
🔬 Life Sciences
💰 $25M Series B led by @QueenCityAngels
prnewswire.com/news-releases…
