@MurthyLab

We are a neuroscience laboratory interested in neural mechanisms of social communication.

 Princeton, NJ
murthylab.princeton.edu
Joined April 2015
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  • Following192
  • Followers2.2K
Excited to announce the completion of the first adult brain connectome - FlyWire is the neuronal wiring diagram of a Drosophila melanogaster brain with >130K neurons and >32M synapses. Explore at codex.flywire.ai. Check out the preprints:
Sven Dorkenwald@sdorkenw
30 Jun 2023
We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses! Explore the connectome: codex.flywire.ai/ Reconstruction paper: biorxiv.org/content/10.1101/… Annotation paper: biorxiv.org/content/10.1101/… 1/6
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Don’t miss out on the Neural Mechanisms of Acoustic Communication GRC - this May in Maine!
GRC/GRS NMAC@GRC_NMAC_2024
7 Mar 2024
1) Time to submit abstracts! The 2024 Neural Mechanisms of Acoustic Communication GRC is drawing closer. There's an awesome line-up of speakers working with birds, flies, monkeys, fish, snakes and more. Additional speakers will be selected from abstracts. Please spread the word!
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How are neurons activated by sensory stimuli? For the past century, the only method for addressing this question has been neurophysiology.
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We are excited to announce that registration is open for the 2024 Neural Mechanisms of Acoustic Communication Gordon Research Conference. The preliminary program is now live: grc.org/neural-mechanisms-of… We invite everyone to apply! See you @ Sunday River, Maine, May 19-24, 2024.
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Murthy Lab retweeted
FlyWire@FlyWireNews
12 Nov 2023
This might make you think twice next time you reach for the fly swatter. The whole brain wiring diagram of the fly! All 140,000 neurons and their 50M synapses are available to explore in Codex, the Connectome Data Explorer: codex.flywire.ai/ #sfn23
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We've updated our preprint on finding one-to-one mappings of DNN neurons and real visual neurons of fruit fly. --> 2x silenced data with new LC31 neuron type --> more LC neural recordings --> FlyWire connectome --> knockout training simulations Enjoy! tinyurl.com/5n7t6tpv
Benjamin Cowley@BenjoCowley
21 Jul 2022
Excited to share a new manuscript! Deep nets are great at predicting visual neurons. Yet, they are unable to tell us which artificial neuron directly corresponds to a biological neuron… until now! biorxiv.org/content/10.1101/… (yes, that is indeed a fictive female fly, good guess!)
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Flies are highly visual animals. That’s obvious to anyone who has ever tried to swat one. So it should be no surprise that eyes are so prominent on the fly head.
By Sanjay Acharya - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63862733

ALT By Sanjay Acharya - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=63862733

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One quick teaser - @DudiFly and Kaiyu Wang identified nearly all sexually-dimorphic neurons brainwide - now possible to trace information flow for social communication and female-specific behaviors. Here is a subset of fru/dsx neurons (render from @alin1194):
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By giving all #flyneuro labs access to the data when we began proofreading, science has proceeded alongside completion of the connectome. More papers highlighting the FlyWire resource coming soon … stay tuned!
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The Murthy Lab @PrincetonNeuro is looking for a research tech! Undergrads please apply! Join our diverse team to work on exciting projects uncovering the neural dynamics and circuit architecture underlying flexible social behaviors - apply here: research-princeton.icims.com…
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#flyneuro colleagues please share with your students. Michael Crickmore and @elliehoopla sent me their amazing students (thank you!) - @KyleThieringer is now off to do a PhD in neuroscience at @UW 🤩
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Murthy Lab retweeted
FlyWire@FlyWireNews
27 Oct 2022
The fly central brain synthesizes sensory stimuli into decisions and actions. For the first time, ALL 46,944 branched and far-reaching neurons of both hemispheres of the central brain have been reconstructed and are available via FlyWire. join.flywire.ai/
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Officially out today @CurrentBiology! Check out @MurthyLab collaborative effort to map and record from fly auditory neurons to build the first auditory wiring diagram in any system. cell.com/current-biology/ful…

Neural network organization for courtship-song feature detection in Drosophila

Baker et al. discover and functionally characterize over 20 new auditory cell types in the Drosophila brain. They map synaptic connectivity among all known auditory neurons and find that the auditory...

cell.com
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yessss it's #BINW22 !! I'm Sama Ahmed, finishing my postdoc in the @MurthyLab at @PrincetonNeuro and starting my lab at @UWPsychology in 5 weeks ! We test how circuit interactions constrain behavior by studying how flies multitask ! @BlackInNeuro #BlackInNeuroRollCall
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Murthy Lab retweeted
FlyWire@FlyWireNews
20 Jul 2022
Take a look at the first auditory connectome! New paper utilizing FlyWire from @Christa_A_Baker et al in @CurrentBiology: cell.com/current-biology/ful… Shoutout to @Drexel_Pretzel who created the drosophila serenade illustration in our graphical abstract. @MurthyLab
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Also excited to announce that @BenjoCowley is starting his own lab @CSHL in the Fall. If you want to work on neural network models of the brain, this is the lab to join!
Benjamin Cowley@BenjoCowley
28 Jun 2022
Update of potential interest: I'll be starting a comp neuro group at Cold Spring Harbor Laboratory @CSHL in Sept 2022! Our group will build closed-loop machine learning techniques and interpretable, data-driven models to understand the step-by-step computations of the brain.
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So proud of @Christa_A_Baker - get in touch to do a postdoc in the Baker lab @NCState - Christa is a fabulous mentor, scientist and role model and her lab will be a trailblazer in solving the neural mechanisms underlying acoustic communication in flies.
Christa Baker@Christa_A_Baker
11 Jul 2022
Excited to share that the Baker Lab will open in Biological Sciences @NCState Jan 2023! We will dissect the neural mechanisms underlying hearing in flies, and how those mechanisms are shaped by evolution. Will be recruiting at all levels so please reach out if interested.
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Latest manuscript from the lab and amazing collaboration with @jpillowtime (one-to-one mapping between deep net units and real neurons in the fly visual system!) - congrats @BenjoCowley @neuroecology and @NiveRangarajan!
Benjamin Cowley@BenjoCowley
21 Jul 2022
Excited to share a new manuscript! Deep nets are great at predicting visual neurons. Yet, they are unable to tell us which artificial neuron directly corresponds to a biological neuron… until now! biorxiv.org/content/10.1101/… (yes, that is indeed a fictive female fly, good guess!)
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