Deborah Naon retweeted
Very interesting: mTORC2-NDRG2-CDC42 axis drives mitochondrial fission indipendently of DRP1
☕️NEW: Singh & co show that fasting or lipid availability stimulates mTORC2 activity in the liver, leading to phosphorylation of NDRG1 and NDRG1–CDC42-mediated mitochondrial fission.
rdcu.be/dfOio
nature.com/articles/s41556-0…
Deborah Naon retweeted
Splicing x mitochondria 💯 loving it
Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria | Science science.org/doi/10.1126/scie…
Deborah Naon retweeted
The results of the beautiful collaboration with the lab of @AntonioZorzano are out in Science! In the paper, we modeled how previously uncharacterized isoforms of MFN2 provide mechanical tethering between mitochondria and ER. Video made with #molywood 🙂
science.org/doi/10.1126/scie…
Deborah Naon retweeted
Ermin2 and Ermit2 do not influence mitochondrial morphology. Ermin2 regulates ER shape and luminal connectivity. Ermit2 is enriched in MAMs. Ermit2 increases ER-mito proximity measured by ddGFP, FEMP, EM. In cells, Ermit2 supports Ca2+ transfer from ER to mitochondria 3/
Deborah Naon retweeted
Mfn2 tethers ER to mitochondria, but what's its partner on the ER? How does it tether heterotypic organelles without fusing them? Deborah discovered that Mfn2 is alternatively spliced in two variants Ermin2 and Ermit2 that lack the GTPase domain and go only to the ER. 2/
Deborah Naon retweeted
In the liver, Ermit2 facilitates ER-mitochondria phospholipid transfer, reduces ER stress caused by Mfn2 ablation and in models of NASH. Molecularly, Ermit2 CC2 domain is required to interact with CC1 and CC2 of mitochondrial Mfn1&2, in a complex apt to stabilize ER-mito 4/
Deborah Naon retweeted
@NaonDeborah's paper, 8y of collaboration with @AntonioZorzano's lab is out! Kudos to Deborah, @SatokoS_PhD and all authors! Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria | Science t.ly/UezR #MCS #mitochondria #ER 1/
Deborah Naon retweeted
This was a very long journey... Thanks @NaonDeborah for your ingenuity and perseverance. She is a star, look out for her next discoveries. Thanks @ERC_Research @FondationLeducq @MDAUSA @mur_gov_ for support, @VIMMPadua @DiBio_UniPD @IRBBarcelona for making this possible. 6/6 LS
Deborah Naon retweeted
📢We are #hiring a #Research Assistant (#LabTechnician) for our Quantitative Stem Cell Dynamics Lab (@FraticelliLab).
The lab focuses on developing #biotechnology to study blood stem cell heterogeneity in #aging & #leukemia.
Apply here➡️bit.ly/3W9G4MY
#IRBJobs #Jobs
Deborah Naon retweeted
🔝¡Enhorabuena al #CaixaResearch Eduard Batlle (@BatlleLab) y a todo su equipo del @IRBBarcelona por este relevante avance en la investigación contra el cáncer!
👏🏽 Muy orgullosos de colaborar con el mejor talento científico.
Sigue leyendo. 👇
nitter.cf/IRBBarcelona/status/15…
🆕 Identification of the cells responsible for colon cancer relapse
🔝work by @BatlleLab, now out in @Nature, shows that early immunotherapy, before surgery, can eliminate these cells before they have started to develop a metastasis.
➡️bit.ly/3G5PJ0S
#IRBScience
🧵⤵️
Deborah Naon retweeted
🚀We’ve reached the end of the 2022 #CaixaResearch Validate training programme.
Today at @CosmoCaixa, 5 investors will take part in a round table discussion, followed by speed-networking with the awardees.
Follow the highlights here [1/13]👇
Deborah Naon retweeted
💡 En España, la proporción de empresas innovadoras, así como el grado en el que estas colaboran con otras empresas y organizaciones, es inferior a la media de la EU-27.
Lo revela este indicador de #ElObservatorioSocial de #FundaciónlaCaixa. ⤵️
Deborah Naon retweeted
We are currently recruiting for a Assistant Professor in Sustainable Polymer Chemistry - the school is entering an exciting period, do you fancy joining us?edzz.fa.em3.oraclecloud.com/…
Deborah Naon retweeted
🆕 El @VHIO presenta nuevos datos que demuestran la eficacia del medicamento pembrolizumab para el cáncer escamoso de cabeza y cuello.
Irene Braña es investigadora de la #UITM-#CaixaResearch y coautora del estudio, presentado en #ESMO22.
vhio.net/es/2022/09/10/vall-…
Deborah Naon retweeted
How has the cancer research landscape in Portugal evolved over the past decade? 🔬🇵🇹
@AspicDe is today presenting the findings of its report:
🔵"Portrait of Research and Innovation in Cancer in Portugal"
With the support of @FundlaCaixa, @FCGulbenkian and @Novartis
Deborah Naon retweeted
🚀 This week is the third #CaixaResearch Validate training week for the 2022 cohort.
The leaders of the 15 projects selected in this year's call will take part in several sessions to learn the ins and outs of financing a biomedical project.
Deborah Naon retweeted
💊 Actualmente, no existen tratamientos farmacológicos para la enfermedad del hígado graso no alcohólico.
Con apoyo #CaixaResearch Validate, Deborah Naon está desarrollando un potencial fármaco para tratarla y mejorar la calidad de vida de los pacientes.
bit.ly/3phEKb6
Deborah Naon retweeted
Want to help set a strategic research agenda to improve our understanding of cancer?
🇪🇺 The EU initiative #MissionCancer has launched a “Call for Expert Working Groups” to identify the research priorities and challenges cancer research.
Learn more! ⤵️
nitter.cf/VHIO/status/1549118119…
📣Join this Call for Experts to help identifying the next challenges in #Cancer research‼️
🇪🇺Be part of an exciting project within the #MissionCancer from #HorizonEurope and contribute to improving our understanding of cancer 👉 bit.ly/FormEUMissionCancer ➕ bit.ly/EUMissionCancerVhio
Deborah Naon retweeted
A @ContraCancerBCN impulsem la recerca en Xarxa, donant suport al projecte co-liderat per @nlbigas (@bbglab-@IRBBarcelona) per estudiar les primeres etapes de desenvolupament del càncer i avançar cap a la seva prevenció ➡️ bit.ly/3v24VG4