A daily word-guessing game. Final answers are all related to neurology or neuroscience. Be careful... proper nouns, plurals, and abbreviations are fair game!
Joined April 2023
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Neurdle 1000!
Thank you to everyone who has stuck with us and our educational neurology games for 1000 days!
Join the creators of Neurdle in game development through GANGLIA: neurdgames.com/ganglia
Neurdle, November 5th, 2025:
A cytotoxic lesion of the corpus callosum (CLOCC; also called MERS, mild encephalopathy with reversable splenial lesion) can come from many different etiologies related to infection, inflammation and medication...cont. below
COVID19 can cause this, and other types of brain inflammation, as reviewed here: pubmed.ncbi.nlm.nih.gov/3400…
Neurdle, October 29th, 2025:
What's scarier than a brain-eating fungus? Absolutely nothing - that's why I'm working on a script for a horror movie called "The Fungus that Ate My Brain," and I'm using this review to help keep it believable: ncbi.nlm.nih.gov/pmc/article…
Neurdle, October 28th, 2025:
Oooooh, a skull - so creepy, so Halloweeny, so normal for housing the brain! Early fusing of sutures leads to a skull deformity called craniosynostosis - a major problem that prevents brain growth...cont. below
that has to be distinguished clinically from the very common and completely benign positional plagiocephaly (when a baby has a kind of flat head, but the brain still grows normally). Read how to distinguish the two here: journals.healio.com/doi/full…
Neurdle, October 27th, 2025:
Happy almost Halloween! Many of us will be eating a lot of sugar this week (why yes, it does increase your risk for dementia - but so does everything else, so why don't you live a little...cont. below:
pmc.ncbi.nlm.nih.gov/article…) so let's celebrate the sugar pill - the placebo. The placebo effect is remarkable in studies of pain, headache, sleep, depression - but also in seizures and dementia (phew! glad I found an antidote to this peanut butter cup).
Here's a paper on the neuroscience of the placebo effect: ncbi.nlm.nih.gov/pmc/article…
Neurdle, October 26th, 2025:
Happy almost Halloween! CASPR2 is not a friendly ghost - it's a cell-adhesion molecule that is important for localization of voltage-gated potassium channels...cont. below
Antibodies to CASPR2 causes an autoimmune encephalitis with a wide spectrum of symptoms (oooh, scary!): ncbi.nlm.nih.gov/pmc/article…
Neurdle, October 24, 2025:
Multiple sclerosis is diagnosed by a separation of demyelinating events in space and time; so it can theoretically be diagnosed clinically, without imaging; but check out all the other elements you CAN use for diagnosis in the new...cont. below:
2024 McDonald criteria, intended to increase sensitivity and specificity thelancet.com/journals/laneu… (paywalled).
But whatever, neuroimmunologists are everywhere. Have you ever considered being a neurologist...IN SPACE? nature.com/articles/s41598-0…
Neurdle, October 1st, 2025:
Don't get caught in the autonomic storm! Paroxysmal sympathetic hyperactivity can occur after severe traumatic brain injury (frontiersin.org/articles/10.…)...cont. below
or in the setting of NMDA-receptor antibody-positive encephalitis (frontiersin.org/articles/10.…) with tachycardia, tachypnea, fever and dystonia.
Neurdle, September 30th, 2025:
Now Twitter is "X" and tweeting is "posting" and the world is difficult, but we still need to figure out a way to communicate neurology ideas with other neurologists and the general public...cont. below
The Neurology Digital Education Collaborative (ndec.institute) created by Jacki Martindale and Jess Goldstein is a great way to learn how to navigate changes in social media - and teach through online tutorials, podcasts, videos, blogs and more. Consider applying!
Neurdle, September 29th, 2025:
The word "neuroprotective" activates my BS detector, but the noble gas xenon has been explored for years in anesthesia...cont. below:
minervamedica.it/en/journals…
as an adjuvant to cooling in neonatal hypoxic ischemic encephalopathy cochranelibrary.com/cdsr/doi… and may help people climb really high mountains faster nejm.org/doi/full/10.1056/NE…