Co-founder of Ousia Pharma. Postdoctoral fellow working on development of novel anti-obesity medicines. Chemistry.
Copenhagen, Denmark
Joined January 2019
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Excited and proud to see the main work from my PhD and postdoc on the development of "GLP-1 directed NMDA receptor antagonism for obesity treatment" out in @Nature today!
nature.com/articles/s41586-0…
1/7 🧵
📚In our Review, we synthesize the rapidly expanding knowledge across the field from the clinical breakthroughs that have reshaped obesity treatment, to the molecular mechanisms behind the next generation of obesity therapies now moving through the pipeline.
The evolving landscape of obesity pharmacotherapy
nature.com/articles/s41573-0…
rdcu.be/fiw7g
This new Review covers the evolution of obesity therapy from GLP1s to multi-receptor agonists, oral formulations, weight-loss quality approaches and tissue-specific drug targeting
Jonas Odgaard Petersen retweeted
The evolving landscape of obesity pharmacotherapy
nature.com/articles/s41573-0…
rdcu.be/fiw7g
This new Review covers the evolution of obesity therapy from GLP1s to multi-receptor agonists, oral formulations, weight-loss quality approaches and tissue-specific drug targeting
Jonas Odgaard Petersen retweeted
1/8
🧠 New review from the lab in @CellCellPress: Brain Control of Energy Homeostasis
We explore how central nervous system circuits regulate energy balance, and how this informs the development of next-generation obesity pharmacotherapies.
🔗 cell.com/cell/fulltext/S0092…
Thrilled to have contributed to this snapshot article on "Brain-Targeting Anti-Obesity Medications" appearing today in @Cell_Metabolism on #WorldObesityDay.
On #WorldObesityDay, we have contributed a SnapShot to a special Issue on Obesity in @Cell_Metabolism covering brain actions of the current and emerging weight loss drugs. @OdgaardJonas @JohansenVBI
@UCPH_health
Free access link: authors.elsevier.com/a/1kiaA…
Jonas Odgaard Petersen retweeted
1/4 New paper out in @MolMetab in which we show that calorie restriction before starting treatment with semaglutide or tirzepatide pushes maximum achievable weight loss by ~8% sciencedirect.com/science/ar…
Jonas Odgaard Petersen retweeted
A few months back, we published a study in @ScienceAdvances demonstrating the potential of targeting postsynaptic glutamate receptor scaffolding proteins, such as PSD-95, for sustained weight loss. Headed by @nicolefadahunsi, @OdgaardJonas and @Met_Sop science.org/doi/10.1126/scia…
Jonas Odgaard Petersen retweeted
Big day for the lab as our latest paper is out in Nature Chemical Biology @nchembio on identifying the oxybipins as new OSBP inhibitors, as well as their mechanism of action and therapeutic applications! nature.com/articles/s41589-0… 1/n
Jonas Odgaard Petersen retweeted
Research Highlight in @NatRevDrugDisc covering our recent paper on targeted NMDA receptor antagonism for obesity treatment nature.com/articles/d41573-0…
Jonas Odgaard Petersen retweeted
Insightful News and Views´ from @Tcook30 and @DarleenSandoval on our recent paper.
4/7 To safely harvest the appetite-modulating effects of NMDAR antagonism, we engineered a first-in-class dual-acting compound that chemically combines GLP-1R agonism and NMDAR antagonism in a single Trojan horse like molecule.
6/7 Check out the informative thread by @ClemmensenC. It has been absolutely amazing working on this piece together, and I am excited to continue working on the next-generation of compounds in @OusiaPharma together with @BueKlein with support from @BioCPH and @Innofond .
7/7 Kudos to all the people involved in this massive collaborative effort from the labs of @ClemmensenC @stromgaardlab @Froelund_lab @tunepers @thewilliamslab @KAKohlmier @atul_deshmukh1 @Thue_Schwartz and @MortenBThomsen from @Metabolcenter at @koebenhavns_uni @UCPH_health
2/7 Genome-wide association studies inform that the CNS should be regarded as a primary target for obesity treatment, and highlights glutamatergic signaling and NMDA receptor-related neuroplasticity in body weight homeostasis.
nature.com/articles/nature14…
Jonas Odgaard Petersen retweeted
Exciting news! My main paper for my PhD in the @ClemmensenC lab with @pranea is now published in @naturecomms! 🎉 It delves into how the body is naturally defended against excessive weight gain. A🧵👇#obesityresearch 1/11 nature.com/articles/s41467-0…
🏆 I am deeply honored to be one of the recipients of the UCPH: BII Life Science Innovation Award 2023 at the SUND Innovation Day 2023. It was truly exciting to showcase our innovative solutions that were born in the @ClemmensenC lab and later incorporated to @OusiaPharma.
We couldn't be more proud of Postdoc @OdgaardJonas and PhD Student @SassFrederike for being among the winners of the UCPH: @BioCPH Life Science Innovation Award at the @UCPH_health Innovation day! 🏆
CBMR is committed to translating its discoveries to accelerate the prediction, prevention, diagnosis and treatment of cardiometabolic disease. 🚀
Learn more about CBMR's Innovation Strategy on our website 👇
cbmr.ku.dk/translation/
