Paul C. Tang (@PaulTangMD) header
Paul C. Tang (@PaulTangMD) profile picture

Paul C. Tang

@PaulTangMD

Cardiac Surgeon | Heart Transplant, Mechanical Circulatory Support, Outcomes Research & Biotechnology | Lab: https://nitter.cf/t.co/w2bHR9VVCS | @MayoClinicCVS | Tweets are my own

Joined December 2018
  • Tweets147
  • Following383
  • Followers1.1K
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Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)Photo by Paul C. Tang (@PaulTangMD)
Hope this video helps to clarify how receptor phase separation influences organ preservation quality. @MayoClinicCVS @MayoTransplant #PhaseSeparation
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Paul C. Tang retweeted
JHLT (@TheJHLT) profile picture
JHLT
@TheJHLTAug 24
Donation after brain and cardiac death leads to differential cell-specific cardiac signaling. An improved understanding of this process can lead to more targeted cardiac preservation techniques for each mode of donation. @PaulTangMD 🔗: jhltonline.org/article/S1053…
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Congratulations I. Lei, PhD, Asst Prof of Physiology & Biomedical Engineering, on being awarded his second R01! This grant supports research exploring how gene organization w/in the nucleus influences age-related susceptibility of donor hearts to preservation injury. @PaulTangMD
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
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Attending #ASC2026? Join @SinaDaneshMD as he presents, "Impact of BMI on Outcomes Following Surgical vs. TAVR", Wed., Feb. 4 @ 8AM! @PaulTangMD
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
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Paul C. Tang retweeted
AATS (@AATSHQ) profile picture
AATS@AATSHQJan 23
New mechanical circulatory support research: Active and passive cardiac indexes as complementary predictors of outcomes after left ventricular assist device implantation. Log in to your #JTCVS account to read more: doi.org/10.1016/j.jtcvs.2025… @PaulTangMD @MayoClinicCVS
Image from AATS (@AATSHQ)
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Paul C. Tang retweeted
AATS (@AATSHQ) profile picture
AATS@AATSHQ13 Nov 2025
New in mechanical circulatory support: Influence of postimplant mitral regurgitation on durable left ventricular assist device outcomes. Learn more from @JundraPeguesMD, @PaulTangMD et al in this #JTCVS article: doi.org/10.1016/j.jtcvs.2025…
Significant mitral regurgitation after LVAD implant is associated with higher mortality.

ALT Significant mitral regurgitation after LVAD implant is associated with higher mortality.

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Thrilled to share our recent work published in #JTCVS Exploring outcomes of #TEER vs surgical correction of #mitral regurgitation in advanced age 🫀 Grateful to Drs @Arghami, @PaulTangMD & @HSchaffMD for their mentorship @MayoClinicCVS @AATSHQ
Image from Sina Danesh, MD (@SinaDaneshMD)
Image from Sina Danesh, MD (@SinaDaneshMD)
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Thrilled to share our work published in Circulation as part of @AHAScience We investigated how aortic annular area influences outcomes after balloon-expandable vs. self-expandable valve-in-valve TAVR. Grateful to Dr. @PaulTangMD and the great team @MayoClinicCVS
Image from Sina Danesh, MD (@SinaDaneshMD)
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Very well deserved recognition for our NP/PA lead, Marci Newcome, DNP. Always going above and beyond!
Mayo Clinic Cardiac Surgery (@MayoClinicCVS) profile pictureMayo Clinic Cardiac Surgery@MayoClinicCVS23 Oct 2025
Congratulations to @MarciNewcome DNP, APRN, CNP, Director of CVS NPPAs-2025 Fellow of APPex! The Fellowship of APPex is the first & only honorary recognition that formally acknowledges APRN & PA administrators & leaders who’ve made exceptional contributions to advanced practice.
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
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Congratulations to @MarciNewcome DNP, APRN, CNP, Director of CVS NPPAs-2025 Fellow of APPex! The Fellowship of APPex is the first & only honorary recognition that formally acknowledges APRN & PA administrators & leaders who’ve made exceptional contributions to advanced practice.
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
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Mineralocorticoid receptor inhibition at the time of cardiac surgery may reduce postop new atrial fibrillation. Opportunities exist to trial this in patients. Congrats to @SinaDaneshMD who worked intensely on this article. @MayoClinicCVS @MayoCVservices @AHAScience
JAHA (@JAHA_AHA) profile pictureJAHA@JAHA_AHA17 Oct 2025
Mineralocorticoid receptor antagonists reduce post-heart surgery atrial fibrillation (#AFib), likely by acting on cardiomyocytes. #AHAJournals @SinaDaneshMD @PaulTangMD @MayoClinicCVS ahajrnls.org/3JeRBs5
Image from JAHA (@JAHA_AHA)
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I. Lei, PhD, Asst Prof of Physiology & Biomedical Engineering @MayoClinicCVS, received an RO1, titled, "Epigenetic regulation of donor heart preservation mediated by Brd4", focusing on delving deeper into the mechanisms w/aim to bring Brd4 drug therapy into the transplant field.
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
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Dr. Carmelo Milano was named 2025 John W. Kirklin Visiting Professor in Cardiac Surgery. Dr. Milano is the Division Chief of Cardiothoracic Surgery at Duke University Medical Center. @JuanCrestanello
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
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Check out this interesting #JAHA article where research experts share their findings. @PaulTangMD
Fazal Khan, MD (@Fazal73392647) profile pictureFazal Khan, MD@Fazal733926479 Oct 2025
Our paper in JAHA @MayoClinicCVS Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post‐Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest | Journal of the American Heart Association ahajournals.org/doi/10.1161/…
Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post‐Cardiac Surgery and Attenua...

Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post‐Cardiac Surgery and Attenua...

ahajournals.org
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Thrilled to share our manuscript in @JAHA_AHA on linking clinical outcomes to molecular insights of AF 👥 19042 Patients 💊 Preop MRA use → ⬇️ Post-op & long-term AF 🧬 snRNA-seq → MRAs suppress atrial stress responses 🔗 ahajournals.org/doi/full/10.… @PaulTangMD @MayoClinicCVS
Image from Sina Danesh, MD (@SinaDaneshMD)
Image from Sina Danesh, MD (@SinaDaneshMD)
Image from Sina Danesh, MD (@SinaDaneshMD)
Image from Sina Danesh, MD (@SinaDaneshMD)
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Excited to share our new paper in #JTCVS 👥 3265 SAVR±CABG (2000–2024) 📉 Mechanical valves→ survival benefit only in larger EOA metrics 🫀 Also assessed AV reintervention, HF readmission, stroke & major bleeding 👉 doi.org/10.1016/j.jtcvs.2025… @PaulTangMD @MayoClinicCVS @AATSHQ
Image from Sina Danesh, MD (@SinaDaneshMD)
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Listen to this podcast featuring @PaulTangMD, "A heartwarming Tale: How Basic Research into Cell Behavior Spurred an Advance in Transplant Surgery" #telluridescience bit.ly/457OPfk
Image from Mayo Clinic Cardiac Surgery (@MayoClinicCVS)
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More discussions on this podcast with journalists George Lewis & Judy Muller on @telluridesci and “Science straight Up”. Huge thanks to Rohit Pappu at Wash U for the in-depth scientific insight on phase separated states. telluridescience.org/podcast… buzzsprout.com/1204337/episo…
Podcasts - Telluride Science

Podcasts - Telluride Science

telluridescience.org
Paul C. Tang (@PaulTangMD) profile picturePaul C. Tang@PaulTangMD25 Jul 2025
Sharing our NCVR article demonstrating how donor heart ischemic tolerance and functional performance can be enhanced by reducing mineralocorticoid receptor phase separation. A clinically utilized MR antagonist, Canrenone, is available now to accomplish this.
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Sharing our NCVR article demonstrating how donor heart ischemic tolerance and functional performance can be enhanced by reducing mineralocorticoid receptor phase separation. A clinically utilized MR antagonist, Canrenone, is available now to accomplish this.
Nature Cardiovascular Research (@NatureCVR) profile pictureNature Cardiovascular Research@NatureCVR22 May 2025
Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. doi.org/10.1038/s44161-025-0… rdcu.be/enbAz
Mineralocorticoid receptor phase separation modulates cardiac preservation

Mineralocorticoid receptor phase separation modulates cardiac preservation

Nature Cardiovascular Research - Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart...

nature.com
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Heartfelt thanks to Ienglam Lei & all collaborators on this very exciting trip down the rabbit hole of organ preservation biology. So many impactful avenues for molecular science to explore in modern surgery. We thank all who supported including @AATSHQ @ThoracicSurgFnd and NIH
Nature Cardiovascular Research (@NatureCVR) profile pictureNature Cardiovascular Research@NatureCVR22 May 2025
Research | Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function. doi.org/10.1038/s44161-025-0… rdcu.be/enbAz
Mineralocorticoid receptor phase separation modulates cardiac preservation

Mineralocorticoid receptor phase separation modulates cardiac preservation

Nature Cardiovascular Research - Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart...

nature.com
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