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Penn CREST

@Penn_CREST

Center for Real World Effectiveness and Safety of Therapeutics @Penn Director:@HennessySean Follow Us @ https://nitter.cf/t.co/3zOiTT9wz4

 Philadelphia, PA
cceb.med.upenn.edu/cpert
Joined April 2015
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  • Followers1.1K
145Media
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We are moving this account to BlueSky. Please give us a follow @ penn-crest.bsky.social ! bsky.app/profile/penn-crest.…
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Great new paper in ACR Open Rheumatology, led by CREST investigator Josh Baker: Characterization of Second-Line Therapy After First JAK Inhibitor Use: Results From the CorEvitas Rheumatoid Arthritis Registry @UPennDBEI acrjournals.onlinelibrary.wi…
Characterization of Second‐Line Therapy After First JAK Inhibitor Use: Results From the CorEvitas...

Characterization of Second‐Line Therapy After First JAK Inhibitor Use: Results From the CorEvitas...

Objective We performed a real-world characterization of patients with rheumatoid arthritis (RA) who initiate a JAK inhibitor (JAKi) and switch to a subsequent therapy and examination of factors...

acrjournals.onlinelibrary.wiley.com
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New in JAMA Health Forum: Stimulant Overdose Prediction Model for Medicaid-Insured Persons @UPennDBEI @HennessySean jamanetwork.com/journals/jam…
Stimulant Overdose Prediction Model for Medicaid-Insured Persons

Stimulant Overdose Prediction Model for Medicaid-Insured Persons

This case-control study develops and validates a model to predict hospitalization or emergency department treatment for stimulant-involved overdose among the Medicaid-insured population.

jamanetwork.com
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New in American Journal of Epidemiology: Effect of exogenous testosterone on cardiovascular, cerebrovascular, and thromboembolic adverse events: Results of three complementary research designs @TatThangVo1 @phuongpng @HennessySean @CE_Leonard academic.oup.com/aje/advance…

Effect of exogenous testosterone on cardiovascular, cerebrovascular, and thromboembolic adverse...

Abstract. The cardiovascular risks of exogenous testosterone have been a subject of controversy. In this study, our objective was to examine the associatio

academic.oup.com
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New in Pharmacoepidemiology & Drug Safety ⬇️ Real-World Data and Real-World Evidence in Regulatory Decision Making: Report Summary From the Council for International Organizations of Medical Sciences (CIOMS) Working Group XIII @HennessySean @UPennDBEI onlinelibrary.wiley.com/doi/…
Real‐World Data and Real‐World Evidence in Regulatory Decision Making: Report Summary From the...

Real‐World Data and Real‐World Evidence in Regulatory Decision Making: Report Summary From the...

Data from sources other than traditional randomized clinical trials are known as real-world data (RWD), and the evidence derived from the review and analysis of RWD is known as real-world evidence...

onlinelibrary.wiley.com
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Great new paper in Clinical Pharmacology & Therapeutics led by doctoral student Haedi Thelen: Characterizing Treatment Effect Heterogeneity Using Real-World Data ascpt.onlinelibrary.wiley.co… @HaediThelen @HennessySean
Characterizing Treatment Effect Heterogeneity Using Real‐World Data

Characterizing Treatment Effect Heterogeneity Using Real‐World Data

Characterizing heterogeneity of treatment effects (HTE) is a fundamental goal of pharmacoepidemiology, addressing why medications work differently across patient populations. This paper reviews...

ascpt.onlinelibrary.wiley.com
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Check out the latest from the CREST team in Pharmacoepidemiology & Drug Safety: Evaluation of Drug–Drug Interactions in Pharmacoepidemiologic Research @Alicechencheng @phuongpng @Miano81 @CE_Leonard @HennessySean onlinelibrary.wiley.com/doi/…
Evaluation of Drug–Drug Interactions in Pharmacoepidemiologic Research

Evaluation of Drug–Drug Interactions in Pharmacoepidemiologic Research

Drug–drug interactions (DDIs) represent a significant concern for clinical care and public health, but the health consequences of many DDIs remain largely underexplored. This knowledge gap undersco...

onlinelibrary.wiley.com
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New publication in Journal of Geriatric Psychiatry and Neurology led by @phuongpng and featuring several CREST investigators ⬇️ Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in Parkinson Disease journals.sagepub.com/doi/ful…
Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in...

Impact of Anticholinergic Burden and Clinical-Demographic Characteristics on Incident Dementia in...

Purpose Anticholinergic medication use measured via the Anticholinergic Cognitive Burden (ACB) scale has been associated with an increased dementia incidence in...

journals.sagepub.com
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A great methods paper featuring several CREST investigators, newly published in the Electronic Journal of Statistics: Structural mean models for instrumented difference-in-differences @TatThangVo1 @HennessySean @UPennDBEI projecteuclid.org/journals/e…

Structural mean models for instrumented difference-in-differences

In the standard difference-in-differences research design, the parallel trend assumption can be violated when the effect of some unmeasured confounders on the outcome trend is different between the...

projecteuclid.org
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Newly published in Clinical Pharmacology and Therapeutics and featuring several CREST investigators: Risk of Hypoglycemia Associated with Concomitant Use of Insulin Secretagogues and ACE Inhibitors in Adults with Type 2 Diabetes: A Systematic Review ascpt.onlinelibrary.wiley.co…
Risk of Hypoglycemia Associated With Concomitant Use of Insulin Secretagogues and ACE Inhibitors in...

Risk of Hypoglycemia Associated With Concomitant Use of Insulin Secretagogues and ACE Inhibitors in...

Insulin secretagogues and angiotensin-converting enzyme inhibitors (ACEIs) are commonly co-prescribed for patients with type 2 diabetes (T2D). Case reports suggesting that co-administration of...

ascpt.onlinelibrary.wiley.com
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Ambient temperature & serious adverse health outcomes among users of different antidiabetes drugs ft. @CE_Leonard, Kacie Bogar, Colleen Brensinger, Warren Bilker, @Alicechencheng & @HennessySean @Penn_CREST @UPenn_CCEB @UPennDBEI @PennSysPharmATT bmjopen.bmj.com/content/14/1…
Image from Penn Medicine CSO (@PennMedCSO)
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Interested in joining the CREST team? We're hiring! ⬇️ Manager Research Project B (Department of Biostatistics, Epidemiology and Informatics) wd1.myworkdaysite.com/recrui…
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Check out the latest in JAMA Network Open, led by CREST investigator Mark Neuman ⬇️ Strategies to Limit Benzodiazepine Use in Anesthesia for Older Adults: A Randomized Clinical Trial @neumanmd jamanetwork.com/journals/jam…
Strategies to Limit Benzodiazepine Use in Anesthesia for Older Adults

Strategies to Limit Benzodiazepine Use in Anesthesia for Older Adults

This randomized clinical trial examines the efficacy of 3 clinician- and patient-facing strategies to reduce the use of benzodiazepines in anesthesia among older adults undergoing surgery.

jamanetwork.com
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Spotlighting an excellent paper by one of our first-year PhD students, Lin-Chieh Meng! Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study @LinChiehMeng bmj.com/content/387/bmj-2024…
Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan:...

Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan:...

Objective To evaluate the association between paternal metformin use and risk of congenital malformations in offspring. Design Population based, cross national cohort study. Setting Norway and...

bmj.com
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Newly published in Clinical Pharmacology & Therapeutics ⬇️ Risk of Opioid Overdose Associated with Concomitant Use of Methadone and Statins @Alicechencheng @Miano81 @CE_Leonard @HennessySean ascpt.onlinelibrary.wiley.co…
Risk of Opioid Overdose Associated with Concomitant Use of Methadone and Statins

Risk of Opioid Overdose Associated with Concomitant Use of Methadone and Statins

Methadone has a high potential for risky drug–drug interactions that can lead to opioid overdose, yet evidence on the magnitude of this risk remains limited. Since methadone is transported via...

ascpt.onlinelibrary.wiley.com
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Check out the latest from the CREST team in Clinical Pharmacology & Therapeutics ⬇️ Concomitant Use of Oral Anticoagulants with Oral Dipeptidyl Peptidase-4 Inhibitors and Serious Bleeding Events @phuongpng @HennessySean @CE_Leonard @Miano81 ascpt.onlinelibrary.wiley.co…
Concomitant Use of Oral Anticoagulants With Oral Dipeptidyl Peptidase‐4 Inhibitors and Serious...

Concomitant Use of Oral Anticoagulants With Oral Dipeptidyl Peptidase‐4 Inhibitors and Serious...

In a prior screening study, saxagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i), was found to have an increased rate of serious bleeding when used concomitantly with several oral anticoagulants...

ascpt.onlinelibrary.wiley.com
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A great first day of sessions at #ISPEAnnual2024 in beautiful Berlin!
Image from Penn CREST (@Penn_CREST)
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New in the American Journal of Epidemiology and led by our talented former post doc Hanxi (Molly) Zhang) ⬇️ Grace periods and exposure misclassification in self-controlled case-series studies of drug-drug interactions @CE_Leonard @HennessySean @Miano81 academic.oup.com/aje/advance…
Grace periods and exposure misclassification in self-controlled case-series studies of drug–drug...

Grace periods and exposure misclassification in self-controlled case-series studies of drug–drug...

Abstract. The self-controlled case-series (SCCS) research design is increasingly used in pharmacoepidemiologic studies of drug–drug interactions (DDIs), wi

academic.oup.com
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Newly published in JAMA Neuro. and led by our own Emily Acton ⬇️ Direct-Acting Oral Anticoagulants and Antiseizure Medications for Atrial Fibrillation and Epilepsy and Risk of Thromboembolic Events @HennessySean @CE_Leonard @UPennDBEI jamanetwork.com/journals/jam…
Direct-Acting OACs and Antiseizure Medications for AF and Epilepsy and Risk of Thromboembolic Events

Direct-Acting OACs and Antiseizure Medications for AF and Epilepsy and Risk of Thromboembolic Events

This cohort study assesses rates of thromboembolic events in adults with atrial fibrillation (AF) and epilepsy receiving direct-acting oral anticoagulants (OACs) and enzyme-inducing antiseizure...

jamanetwork.com
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Check out the latest in JAMA Internal Medicine featuring several CREST investigators ⬇️ Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data @HennessySean @UPennDBEI jamanetwork.com/journals/jam…
Severe Acute Liver Injury After Hepatotoxic Medication Initiation

Severe Acute Liver Injury After Hepatotoxic Medication Initiation

This cohort study identifies the most potentially hepatotoxic medications based on clinical incidence rates of hospitalizations for severe acute liver injury (ALI) and examines how these rates...

jamanetwork.com
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