Roy lab

New Pre-pint from our team ⁦⁦@RedefiningMECFS⁩ . Genetic depletion of early autophagy protein ATG13 impairs mitochondrial energy metabolism, increases oxidative stress, and preferentially induces the pro inflammatory M1 phenotype of macrophages. researchsquare.com/article/r…

We @RedefiningMECFS and @AvikRoy74969264 are excited to share some early results of our low dose rapamycin project in its pre-print version here. Thanks to all the patients for participating! researchsquare.com/article/r…

Congrats to the entire team @RedefiningMECFS and @AvikRoy74969264 on this breakthrough paper describing a disease-relevant model of PEM link.springer.com/content/pd… Here, we show that chronic mTOR activation disrupts autophagy function, leading to PEM and the production of IL-6 and RANTES via STAT3 phosphorylation!

We continue to make good progress on the Rapamycin trial. I’m so thankful to the participants. You can’t do this kind of research without their guidance and participation. The quote below is one of many. Not everyone will respond. This isn’t my first rodeo. Our goal is biomarker directed clinical trials—like we are doing now. Understanding responders to therapy will help the field of #MECFS and #LongCovid. Thanks to our collaborators @GrachStephanie @CornellMECFS @BatemanHorne David Kaufman MD, Bela Chheda MD, Dan Peterson MD and Jon Berner MD. “I am a responder to the rapamycin. I am not sure if the details are of any interest or maybe helpful to the research but I’ll include a few. The next day after taking my first dose, I noticed immediately I was able to retain twice the amount of water I usually do (I have a schedule of water and salt intake for POTS). For the next four days I incrementally felt this sensation of blood returning to my brain, kind of like when your arm falls asleep and it feels tingly when it “wakes up”. I was 100% bedbound before starting and now I can sit at my desk for 4 hours. I will be attempting more movement here shortly. The RELIEF in my brain is astronomical. My anhedonia and dissociation has hugely improved, I can feel some emotions again from my memories.” Thanks for your support of @RedefiningMECFS

Please check out Simmaron's newest publication here! Thank you to all of the patients and our supporters! doi.org/10.1177/117957352412… “Dysregulation of tetrahydrobiopterin metabolism in myalgic encephalomyelitis/chronic fatigue syndrome by pentose phosphate pathway” @RedefiningMECFS @AvikRoy74969264 @PlzSolveCFS @NINDSdirector @NIH_NINDS

Huge congrats to Molly Drosen and Amy Reyes for taking 1st and 2nd place presenting their posters describing key mechanisms underlying ME/CFS at the UWM annual chemistry symposium! Great mentorship from Avik Roy!! @UWM @RedefiningMECFS @AvikRoy74969264

Rapamycin pilot study. Happening now in the US. It’s cheap (off patent and available). We hypothesize chronic mTOR activation drives autophagy disruption. pubmed.ncbi.nlm.nih.gov/3548… Check out simmaron.com for details.