Dave Leigh (@ProfDaveLeigh) header
Dave Leigh (@ProfDaveLeigh) profile picture

Dave Leigh

@ProfDaveLeigh

Royal Society Research Professor & Sir Samuel Hall Chair of Chemistry, University of Manchester, UK. European. molecules・ machines・ magic

 Manchester, England
catenane.net
Joined June 2016
  • Tweets1.7K
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  • Followers10K
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Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)Photo by Dave Leigh (@ProfDaveLeigh)
Havana bad day? Brighten it up with this guide to synthetic molecular machines from the brilliant @acapellascience 🤖❤️🤖 bit.ly/2NgIHIy
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Dave Leigh retweeted
SOC-UMU Lab (@socumu_lab) profile picture
SOC-UMU Lab@socumu_labOct 5
Just out in Org Chem Front! New mechanically interlocked systems having an extended Leigh-type ring: tight enough for selective β-lactam cyclization, large enough for product release. Congrats done team 👏👏 Thanks @UMUdivulga @AgEInves @FundacionSeneca 👉 doi.org/10.1039/D6QO01315E
Image from SOC-UMU Lab (@socumu_lab)
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Delighted to team up with my old school @codsallhigh to encourage & celebrate achievements of potential scientists that don’t look like me. Congrats Cayten & Roisin! #GirlsinSTEM #diversity
Image from Dave Leigh (@ProfDaveLeigh)
Image from Dave Leigh (@ProfDaveLeigh)
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It was a pleasure to host Ruby, recent @codsallhigh prize winner, for a month's research in our lab over the summer. Wishing you great fun & success reading biochemistry @unibirmingham!
Image from Dave Leigh (@ProfDaveLeigh)
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Research Highlight now online: Rotaxane synthesis inside out by @jetsinglee nature.com/articles/s44160-0… ($) Highlighting the @NatureChemistry Article by David A. Leigh and co-workers
Rotaxane synthesis inside out

Rotaxane synthesis inside out

Nature Synthesis - Rotaxane synthesis inside out

nature.com
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Excited to share our new work out @NatureChemistry An overhand knot synthon enables the formation of trefoiled polymers with tunable topological and chemical features, directly visualized by STM . rdcu.be/fq0Uf Congratulations to the whole team!
Image from Liang Zhang (@LiangZhang1023)
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Metal‐Free Active Template: A Straightforward Route to 4‐Aminopyridinium‐Based Rotaxane Molecular Shuttles - Stoyanov - Angewandte Chemie International Edition - Wiley Online Library onlinelibrary.wiley.com/doi/…
Metal‐Free Active Template: A Straightforward Route to 4‐Aminopyridinium‐Based Rotaxane Molecular...

Metal‐Free Active Template: A Straightforward Route to 4‐Aminopyridinium‐Based Rotaxane Molecular...

Leigh's metal-free active template-based SNAr of an amine on halogenopyridiniums, in the presence of a crown ether, successfully afforded 4-aminopyridinium-containing rotaxanes. Further molecular...

onlinelibrary.wiley.com
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Dave Leigh retweeted
J. Am. Chem. Soc. (@J_A_C_S) profile picture
J. Am. Chem. Soc.@J_A_C_SMay 20
Conformationally Switchable Molecular Trefoil Knot Assembled From 2,6-Bis(1,2,3-triazol-4-yl)pyridine (btp) Building Blocks | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Conformationally Switchable Molecular Trefoil Knot Assembled From 2,6-Bis(1,2,3-triazol-4-yl)pyri...

Conformationally Switchable Molecular Trefoil Knot Assembled From 2,6-Bis(1,2,3-triazol-4-yl)pyri...

Abstract. We report an efficient lanthanide-template synthesis of a conformationally switchable molecular trefoil knot assembled from three 2,6-bis­(1,2,3-

pubs.acs.org
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Online petition and open letter to the University of Nottingham in response to its plans for redundancies in the School of Chemistry @ChemistryUoN. nottinghamchemistry.github.i…
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It is the wrong choice to cut key staff in @ChemistryUoN, one of the best chem depts in the UK. They are responsible for educating & training the next generation of scientists who will deliver the skills, discoveries & industrial capacity on which high-value sectors depend. 1/2
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Weakening this provision undermines the pipeline of talent & innovation that national policy gov.uk/government/publicatio… says the UK urgently needs to strengthen. 2/2
The value of public R&D

The value of public R&D

DSIT analysis on the economic and social benefits to the UK generated by public R&D investment.

gov.uk
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【拡散希望】 分子科学研究所生命・錯体分子科学研究領域の教授１名を公募中です。奮ってご応募ください！ 職務内容：新規機能・物性開拓を目指した物質創製の実験研究 公募締切：２０２６年８月１０日（月）（必着） 着任時期：２０２７年２月１日以降のできる限り早期 ims.ac.jp/recruit/2026/08/08…
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Congrats to Leigh group members Valerie Bruyr & Dan Tetlow (neither on X), consultants shorturl.at/2n5dQ for the new @bbcbitesize GCSE Chemistry series that is now live! bbc.co.uk/bitesize/guides/zx… Featuring @bigmanny1_ (TikTok+Insta = >3.6M followers!🤯) Great job!🧪
Image from Dave Leigh (@ProfDaveLeigh)
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Hi folks I’m on the ballot for President of the RSC (no longer on X). I’m standing because we live in post-truth times where respect for expertise & evidence can no longer be taken for granted. It’s time to push back.If that resonates members can vote at mi-vote.com/secure/rsc🙏
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To vote at mi-vote.com/secure/rsc enter your email in the ‘send-me-my-voting-code’ box. If no code arrives, it may be that you've unsubscribed from membership emails. If so members can email the RSC to get a voting code (email me if you want to know who to contact there).
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The Conservative plan to cut the budget of UK Research and Innovation by 20%, reallocating the money to defence, is a signal that a 20 year old cross-party consensus on science funding has come to an end...
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Dave Leigh retweeted
Chem (@Chem_CP) profile picture
Chem@Chem_CPMar 27
Online now: Out-of-equilibrium sensing with a chemically fueled molecular machine dlvr.it/TRkWqf
Image from Chem (@Chem_CP)
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Online now: Directing chiral self-sorting in molecular knots dlvr.it/TRYxcH
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Excited to see our recent work on the electroreductive cleavage of C(sp³)–N bonds in saturated N-carbonyl heterocycles out in @J_A_C_S🔌Check the full study here: pubs.acs.org/doi/10.1021/jac…
Electroreductive Cleavage of C(sp3)–N Bonds in Saturated N‑Carbonyl Heterocycles

Electroreductive Cleavage of C(sp3)–N Bonds in Saturated N‑Carbonyl Heterocycles

Abstract. Ring-opening C–N bond cleavage reactions provide an effective means to convert widespread, readily accessible chiral N-heterocycles into hard-to-

pubs.acs.org
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Our new video by @Biocinematics depicting the original Maxwell’s Demon thought experiment😈 tinyurl.com/3ja25xfz, the archetypal information ratchet that inspires how we design molecular motors & pumps tinyurl.com/msn8c2an tinyurl.com/yj53rfvm tinyurl.com/557vcubt
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Acceleration of [2]Catenane Formation by One of its Rings (Jean-Claude Chambron) #AngewandteHighlight • onlinelibrary.wiley.com/doi/…
Acceleration of [2]Catenane Formation by One of its Rings

Acceleration of [2]Catenane Formation by One of its Rings

This highlight underscores the most straightforward synthesis of [2]catenanes from readily available molecular precursors: The one-pot, two-step catenane formation from a crown ether, a linear...

onlinelibrary.wiley.com
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Fantastic talk by @MarkLautens the @UoMChemistry 2025 T Y Shen Lecturer! Ably supported by…
Image from Dave Leigh (@ProfDaveLeigh)
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….Drs Clare Megarity & Jack Rowbotham😃
Image from Dave Leigh (@ProfDaveLeigh)
Image from Dave Leigh (@ProfDaveLeigh)
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