Philip Dunne (@ProfPipDunne) header
Philip Dunne (@ProfPipDunne) profile picture

Philip Dunne

@ProfPipDunne

Molecular evolution in colorectal cancer. Professor in Belfast @QUBelfast & Senior Group Leader in Glasgow @CRUK_SI

 Belfast, Northern Ireland
Joined November 2012
  • Tweets4.4K
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  • Followers1.8K
Massive congrats to @MallSid – just published in @NatureGenet Our study defines a series of pathway-derived subtypes (PDS), which we use as the basis for identifying a previously overlooked phenotypic landscape in colorectal cancer… nature.com/articles/s41588-0… 🧵👇
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
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Philip Dunne retweeted
Chris Tape (@christophertape) profile picture
Chris Tape@christophertapeJun 19
Link to bioRxiv: biorxiv.org/content/10.64898…
Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer

Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer

Colorectal cancer (CRC) tumours with high stromal content have a worse outcome, but the mechanisms governing this are unclear. Using high-throughput single-cell perturbation analysis of CRC patient...

biorxiv.org
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Another wonderful collaborative study from the Tape lab, that exemplifies the value of our CRUK CRC-STARS network 👇
Chris Tape (@christophertape) profile pictureChris Tape@christophertapeJun 19
Why do COX-inhibitors like aspirin and celecoxib help prevent and treat colorectal cancer (CRC)? Our new preprint suggests part of the answer is that they work as ‘anti-plasticity’ drugs. (1/7)
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Philip Dunne (@ProfPipDunne) profile picture
Philip Dunne@ProfPipDunneJun 8
The brilliant @RAmirkhah presenting her work at @EACRnews in Budapest. Supported by @CRUKresearch @AlCRIproject
Image from Philip Dunne (@ProfPipDunne)
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The brilliant @RAmirkhah presenting her work at @EACRnews in Budapest. Supported by @CRUKresearch @AlCRIproject
Image from Philip Dunne (@ProfPipDunne)
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What’s a bioinformaticians favourite TV station? The tSNE channel.. 🥁
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What if a cancer-causing mutation were less like a ticking time bomb and more like an actor waiting for the right opportunity? Team SPECIFICANCER’s brand new paper gives us an insight. The new paper from SPECIFICANCER, published in @Nature, reveals that it’s not just the mutation that matters — it’s where in the liver that mutation appears. Understanding which cells can turn cancerous — and why — helps us better predict risk and develop smarter, more targeted treatments. Congratulations to the #CancerGrandChallenges SPECIFICANCER team (co-funded by @TheMarkFdn). This work was led by Owen Sansom and Future Leader Alex Raven. 👉 Read more from Alex: lnkd.in/eTVh9YY6 #CancerResearch
Image from Cancer Grand Challenges (@CancerGrand)
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Alex Raven (@AlexRavenBio) profile picture
Alex Raven@AlexRavenBio20 Nov 2025
Very proud of all our hardwork! Exciting new paper exploring the origin of liver cancer nature.com/articles/s41586-0… @owen_sansom
Hepatic zonation determines tumorigenic potential of mutant β-catenin

Hepatic zonation determines tumorigenic potential of mutant β-catenin

Nature - Zonal positioning in the liver determines whether the CTNNB1 oncogene can induce liver cancer.

nature.com
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🔬 New review in Gut: Cutting-edge endoscopy, spatial imaging & AI enable real-time assessment of the intestinal barrier in IBD. Key to linking gut–brain–liver axes, predicting outcomes & finding new targets 🌱 @Gut_BMJ gut.bmj.com/content/73/10/17…
Image from Matthias Hardtke-Wolenski (@HardtkeWolenski)
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Scott Kopetz (@skopetz) profile picture
Scott Kopetz@skopetz29 Aug 2025
Exciting science and clinical efficacy in this @MDAndersonNews team science study led by @VanMorrisMD In Cancer Cell. Triple therapy with IO led to durable responses in BRAF V600E MSS colorectal cancer, showing promise. Randomized study ongoing. #crcsm cell.com/cancer-cell/fulltex…
Image from Scott Kopetz (@skopetz)
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What a week in Glasgow at the Beatson conference @CRUK_SI Highlights for me were talks from Karuna @KarunaGaneshLab , Ken @KenLauLab and Laura Wood 🤩 And our very own Raheleh @RAmirkhah
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
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@lauradelongwood Fantastic to meet you for the first time too, really enjoyed the company and the talk.
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Ken Lau Lab (@KenLauLab) profile picture
Ken Lau Lab@KenLauLab1 Jun 2025
Thank you to @CRUK_SI and @DrPipDunne for a wonderful experience in Scotland for #BICC2025. Congratz to @K_Harsim for receiving the outstanding poster award!
Image from Ken Lau Lab (@KenLauLab)
Image from Ken Lau Lab (@KenLauLab)
Image from Ken Lau Lab (@KenLauLab)
Image from Ken Lau Lab (@KenLauLab)
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Great opportunity to catch up with so many people, to collaborate and discuss science with the speakers 🧬 Enjoyed playing a small part within the committee and looking forward to next year already.
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
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We caught up with researchers from PGJCCR's @DrPipDunne Lab about their trip to April's @AACR Conference in Chicago. @NatalieFisher03 & @MallSid explained how it connected them with collaborators and set out to shape the direction of future research: qub.ac.uk/research-centres/c…
Image from The Johnston Cancer Research Centre (@QubCancer)
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HUGE congratulations to @skopetz @MDAndersonNews who will lead a multi-institutional consortium (CRC-ASCEND) on implementing adaptive clinical trials in #ColorectalCancer. Kudos to the whole team, including oncologists, program managers and patient advocates. @fireflyann
Image from Anirban Maitra (@Aiims1742)
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Thanks @QUBelfast @HelenColemanQUB for inviting @DrAmandaJCross to give the Charlotte Jackson Gift Lecture today. A great opportunity to share our @CR_UK funded work on the early detection of #BowelCancer & how our findings are influencing policy and patient care #CancerResearch
Image from Cancer Screening & Prevention Research Group (@CSPRG_Imperial)
Image from Cancer Screening & Prevention Research Group (@CSPRG_Imperial)
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After 4 days of blistering sunshine on the Ayrshire coast with the family, heading back on the ferry to the homeland this evening. Looking out at the 12 mile gap that is the closest points separating Scotland & Ireland. Absolutely love these two places ☀️☘️🏴󠁧󠁢󠁳󠁣󠁴󠁿☀️
Image from Philip Dunne (@ProfPipDunne)
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Sunshine and science in Glasgow today at the CRC-STARS kick off meeting in @CRUK_SI Excellent presention from @RAmirkhah charting phenotypic evolution during cancer development and progression, and how best we can use preclinical models of cancer to improve patient outcomes
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
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Replying to @ProfPipDunne @CRUK_SI @AcrCelerate @MRC_NMGN_Cancer @owen_sansom @leedham_simon
Thrilled to share our work at the CRC-STARS kick-off meeting. Grateful to be part of this fantastic program and inspired by the many excellent talks. Excited for the discoveries ahead and the chance to contribute to impactful research!
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Sunshine and science in Glasgow today at the CRC-STARS kick off meeting in @CRUK_SI Excellent presention from @RAmirkhah charting phenotypic evolution during cancer development and progression, and how best we can use preclinical models of cancer to improve patient outcomes
Image from Philip Dunne (@ProfPipDunne)
Image from Philip Dunne (@ProfPipDunne)
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