
Autistic/bipolar/multiply-neurodivergent psychiatrist and autism researcher Serious statistician, unserious person Lifelong Bayesian PGY-2 @UCLApsychres
Los Angeles, CA
Joined June 2012
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Finally landed in LA and checking out the places I'll be spending most of my waking hours inside as part of @UclaPsychRes. Proud to be a part of @UCLASemel and back on the best coast after my 12-year hiatus. Guess you can't keep this California boy away from tacos and the beach! – at Westwood, Los Angeles
Zack Williams, MD, PhD retweeted
Generative Psychometrics with AI-GENIE (Automatic Item Generation and Validation via Network-Integrated Evaluation) has now more than 4k downloads, and >50 citations (paper + pre-print): Quite Amazing! link.springer.com/article/10…
Now that's something worthwhile to add to the evidence base (cariprazine [vraylar] for irritability in autism)!
Cariprazine joins aripiprazole and risperidone as options for irritability in autism with this new industry-sponsored trial.
However, I recommend other options first line:
psych-partners.com/cariprazi…
Zack Williams, MD, PhD retweeted
"Diagnostic revision may correct error; it may also threaten identity, access to support and self-understanding, fall unequally on particular groups, or become a mechanism for rationing" pubmed.ncbi.nlm.nih.gov/4292… From @DrMariosAdamou et al. De-diagnosis is a rising topic.
Are We Still Talking About the Same Syndrome?
Self-report and behavioral inferences are imperfect, but they can still tell us a lot via @awaisaftab
psychiatrymargins.com/p/are-…
Zack Williams, MD, PhD retweeted
Retatrutide, the most potent GLP-1 agent in this family of drugs to date, had a marked benefit vs sleep apnea in a randomized trial, in people with obesity, just published @NEJM AHI-apnea-hypopnea index
nejm.org/doi/full/10.1056/NE…
Zack Williams, MD, PhD retweeted
To whom it may concern,
Medicine needs to stop glorifying 24-hour workdays and 80-hour work weeks.
They compromise a physician's health.
Sleep-deprived physicians are more prone to error which compromises patient care.
Medicine needs to evolve by letting go of outdated rites of passage.
Zack Williams, MD, PhD retweeted
“When I found an antipsychotic that works for me, it was like drinking from a firehose of lucidity. It was too much, too fast, too soon. After years of unrecognized on-and-off psychosis, normal sanity felt alien.” Sam de Selby
psychiatrymargins.com/p/trea…
Zack Williams, MD, PhD retweeted
The Generative Psychometrics Newsletter (subscribe for free here: generativepsychometrics.com )
AI-GENIE is now available on CRAN
The AI-GENIE R package for Automatic Item Generation with Network-Integrated Evaluation is now officially available on CRAN. You can install it directly with install.packages("AIGENIE").
View AI-GENIE on CRAN: cran.r-project.org/web/packa…
AI-GENIE tutorial paper updated
Our tutorial paper on AI-GENIE has been updated with the latest version. You can read the new version on arXiv and PsyArXiv:
arXiv: arxiv.org/abs/2603.28643
PsyArXiv:osf.io/preprints/psyarxiv/ar…
PCA vs EGA paper updated
Our paper comparing PCA and Exploratory Graph Analysis for Generative Psychometrics has also been updated:
PsyArXiv: osf.io/preprints/psyarxiv/2s…
Thank you for following our work. More updates are coming soon.
Best regards,
Hudson Golino
The Generative Psychometrics Team
generativepsychometrics.com
Zack Williams, MD, PhD retweeted
🧵The (Dying) Art of Prescribing an Inpatient Admission ( from a previous post) 🚨1/2
Much like the declining use of Clozapine, MAOIs, and Lithium, the practice of prescribing a well-organised and targeted inpatient admission is gradually losing its prominence.
Here are my insights as an inpatient psychiatrist over the last 10 years and why it’s one of the most powerful interventions in psychiatry. 👇
There is a misconception in psychiatry that in-patient psychiatry is only about the acutely unwell or acute psychosis.
This cannot be further from the truth.
In my role, I navigate through a myriad of cases, covering a broad spectrum, often at the end of multiple opinions and referrals from across the country.
Inpatient psychiatry, while capable of addressing acute cases, offers a unique advantage beyond the acute spectrum.
1. It sets up a powerful foundation for Understanding and Problem Solving.
2. It allows the psychiatrist, the team and the patient the opportunity to maximise the potential of treatment.
3. The aim is to maximise patient functioning
“If I had an hour to solve a problem, I'd spend 55 minutes thinking about the problem and five minutes thinking about solutions”. (Einstein)
The Value of In-patient Admission:
1/ Information points :
When it comes to problem-solving, the most valuable ingredients are information points.
In-patient admission helps generate a concentrated source of information.
Consider it a melting pot where insights from registrars, psychologists, social workers, occupational therapists, nursing staff, and medical colleagues blend, compressing years of information into just a few weeks.
Add information points from the patient and family through daily observations, which act as powerful material for problem-solving.
2/ A unique holding and containing environment:
Daily throughout the entire duration of the admission, a psychiatrist holds and contains the patient's information in their mind that doesn’t stop at the end of the day.
Each implemented step prompts the psychiatrist to contemplate the anticipated change or outcome.
3/ The Initial Stages:
The initial phase of the admission often involves psychopharmacology (symptom relief moving to more targeted pharmacology as the formulation evolves), as a significant amount of treatment resistance involves untreated biological/medical components.
In the initial stages, it's not just about treating the severe symptoms; it's about enhancing pattern recognition.
Robust pattern recognition is built upon four pillars:
Phenomenology - Neuroscience - Psychopharmacology - Treatment Choice
The most effective approach to boost pattern recognition involves repeatedly cycling through the stages of:
Predict - implement - evaluate - change
within a condensed timeframe.
Consider it akin to mini-audits, and more significantly, envision the invaluable learning from this iterative process!
Inpatient admission condenses years of interventions into a compact, well-defined, and strategically managed process.
It ensures the patient can witness tangible changes, like improvements in cognition, activity, sleep, and perception (PACES), all to achieve reasonable homeostasis.
This part is relatively easy.
4/ Testing Hypotheses (System 2 Thinking):
An in-patient admission curtails the psychiatrist's dependence solely on their judgment.
It underscores the principle that 'improvement is a multi-opinion endeavour.'
The unconscious yearning for improvement within the doctor is subjected to the litmus test of actual improvement, as observed by other team members.
Moreover, accountability takes centre stage.
The management of medication-induced side effects becomes the responsibility of the psychiatrist, operating within the broader team framework.
This approach can ‘force’ thoughtful consideration in the choices of treatments.
Continued 👇
Zack Williams, MD, PhD retweeted
🚨 The FDA has approved olanzapine (Weltruza) extended-release injectable suspension, a once-monthly subcutaneous long-acting injectable, for adults with schizophrenia. psychiatrictimes.com/view/ol…
Zack Williams, MD, PhD retweeted
Trikafta is one of the most inspiring medical advances in decades.
Approved in 2019, the drug at first makes cystic fibrosis patients vomit up mucus for about a week.
They lose that week and then they gain a lifetime–a healthy, *normal length* lifetime.
Pharma brings miracles!
Zack Williams, MD, PhD retweeted
Key points from new analyses:
▪ Methylphenidate is not addictive when used for ADHD
▪ XR versions are less rewarding
▪ Tolerance develops to rewarding, energizing qualities, not to ADHD benefits
Zack Williams, MD, PhD retweeted
"first do no harm" is not a thing and would paralyse virtually every medical option
- me, for the gajillionth time
I swear people say all sorts of things without thinking
Replying to @tylerblack32
What you are doing is crime..
First rule Primum non nocere.
The dean of harvard warn from acetaminophen and autism..
This what we must do.. primum non nocere..
Ones must be blind not to see the rising autism prevalence and understand that ignoring harvard dean is the reason
Zack Williams, MD, PhD retweeted
SAINT (SNT) TMS once promised outsized recovery rates for refractory depression, but two new trials from independent centers bring it back to earth:
psych-partners.com/a-setback…
Thanks for the find @RecoveryDoctor
Zack Williams, MD, PhD retweeted
BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
New from the CDC in @JAACAP
doi.org/10.1016/j.jaac.2026.…
Different operationalizations of profound autism criteria were applied to the latest (2022) ADDM prevalence numbers. The 2025 Delphi-based definition (link.springer.com/article/10…) was used as a starting point.
▪️ 16.5% of autistic kids (0.5% of all kids) had PA by 2025 criteria (MV/NV OR low IQ) + low global adaptive functioning))
▪️ Prior (Lancet) definition had 33.5% higher prevalence
▪️ Allowing for mild ID to be included in the consensus definition increased prevalence 70.9%
▪️ Dropping the IQ criterion altogether (similar to federal IACC definition of MV/NV + safety concerns) reduced prevalence by 33.3%
Zack Williams, MD, PhD retweeted
Which antipsychotic is most effective for aggression in schizophrenia?
Clozapine, concludes new network meta-analysis, followed by paliperidone and olanzapine. See full ranking:
psych-partners.com/antipsych…
Zack Williams, MD, PhD retweeted
As I've been saying:
"In this nationally representative cross-sectional survey of US adults, self-attributed adverse outcomes were most frequent among respondents reporting ibogaine or 5-MeO-DMT use."
jamanetwork.com/journals/jam…
Exploring the Perspectives of Siblings of Autistic Adults With Distressing Behavior: Perceptions of Positive and Negative Impacts | Journal of Autism and Developmental Disorders | 2026 link.springer.com/article/10…
Zack Williams, MD, PhD retweeted
Autistic & non-autistic "same-neurotype dyads... did not communicate more efficiently than mixed-neurotype dyads" "no differences in rapport were found between same- & mixed-neurotype dyads" link.springer.com/article/10… "findings challenge key predictions of the double empathy theory"
































