@RasmusIv

Immunologist and B-cell enthusiast at Oslo University Hospital.

 Oslo, Norway
Joined August 2018
  • Tweets137
  • Following281
  • Followers351
Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved! biorxiv.org/content/10.1101/…

Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tract

The mucosa lining the gastrointestinal tract harbors the body’s largest population of plasma cells, most of which produce dimeric IgA destined for release into the lumen. In addition, there is...

biorxiv.org
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Rasmus Iversen retweeted
Waggoner Lab@LabWaggonerJul 26
Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tract @CellReports cell.com/cell-reports/fullte… @RasmusIv @UniOslo 🇳🇴
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My lab is looking for an antibody engineer-protein biochemist to study ~500 patient derived monoclonal antibodies. Towards novel insights into autoAb-mediated neurological diseases #encephalitis #nmo #protein #antibody Come n work at wonderful @MayoClinic Florida🏖️ Pls email me
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Notably, while IgA plasma cells in the bone marrow were almost exclusively of the IgA1 subclass, gut plasma cells showed an equal distribution between IgA1 and IgA2.
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Collectively, our results suggest that systemic and gut IgA responses against bacteria originate from discrete anatomical sites with inductive sites in the upper aerodigestive tract likely playing a prominent role in generation of systemic IgA.
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I am looking for a PhD candidate to join my lab in Oslo! We are trying to understand the role of antigen-specific B cells in autoimmunity. See details and apply here 👇 2411.webcruiter.no/Main2/Rec…
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Very excited to share our paper on enzyme-activating BCRs and their role in gluten-sensitive autoimmunity! rdcu.be/ecXfG bsky.app/profile/rasmusi.bsk…
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We have an open 2-year postdoc position focusing on computational approaches to identify antigen-specific immune receptors from adaptive immune repertoire data. Application deadline: Nov 6. jobbnorge.no/en/available-jo…
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So excited! Hot off the press in @Nature We present a human autoimmune organoid model capable of mimicking celiac disease. | driven by Antonio Santos! | Calvin Kuo Lab @StanfordMed nature.com/articles/s41586-0…
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Our paper on the linguistics-based formalization of antibody language is out in @NatComputSci. Work led by @MaiSpaceHa Rahmad Akbar and @PRobertImmodels . Summary thread: nitter.cf/PRobertImmodels/status….
Nature Computational Science@NatComputSci14 Jun 2024
📢 @maispaceha, @PRobertImmodels, @BartlomiejSwia4, @SandveGeir, @victorgreiff et al. explore the potential of linguistic formalization of antibody language to improve rule mining in deep LMs for antibody sequence analysis. nature.com/articles/s43588-0… ➡️rdcu.be/dKOdq
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Happy to share this story on autoreactive naive B cells of relevance to celiac disease. Out now in the Journal of Autoimmunity. More details in 🧵 sciencedirect.com/science/ar…
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The selected B cells are the ones that can interact productively with gluten-specific T cells. This requires that the B cells bind active TG2, which can form complexes with gluten. Hence, only some epitopes are permissive, and these end up dominating the autoantibody response.
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Collectively, our study highlights the role of efficient T cell-B cell collaboration in development of celiac disease and production of disease-specific autoantibodies.
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Our paper on circulating autoreactive B cells in celiac disease is now out in @CellReports 🎉. Big thanks to everyone involved! cell.com/cell-reports/fullte…

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease

Celiac disease is associated with IgA-class autoantibodies to transglutaminase 2 (TG2). Lindeman et al. identify TG2-specific IgA+ B cells in the blood of celiac disease patients. These cells are...

cell.com
Rasmus Iversen@RasmusIv24 Oct 2023
Very happy to share this story on autoreactive B cells in celiac disease together with @IdaLindeman @LeneHoydahl @ChristophAsb @LouiseFRisnes @JCoDiRC. Here, we identify a population of circulating IgA-switched B cells specific to the self-antigen transglutaminase 2 (TG2).
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I am so happy to share that our study has been published today in @Nature ! 🎉This has been an absolutely fantastic teamwork between @emilyethornton, @haemyisu @powrie_lab and @teichlab [Link: rdcu.be/dDzwx]
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New opening for a PhD student in my lab, co-supervised with @F_Lund_Johansen . This position is ERC-funded and focuses on novel experimental technologies for antibody-antigen binding screening 📷 jobbnorge.no/en/available-jo…
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