Redi Metali (@RediMetali) profile picture

Redi Metali

@RediMetali

G6 PhD Student @Moazed_Lab | @harvardmed. Previously in the Mello lab @RTI_UMassChan

 Boston, MA
Joined August 2012
  • Tweets28
  • Following202
  • Followers104
Join us on April 24 for the #HIRM #RNA Medicine 10th Annual Symposium feat. Keynote Speaker @Craigedit from @UMassChan Register now: lp.constantcontactpages.com/…
Image from Frank J. Slack, PhD (@irmdirector)
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Happy to share with the world that the main body of my PhD thesis (and my rotation project) on the mechanism for replisome-mediated parental histone inheritance is published in @CellCellPress today🥰! cell.com/cell/fulltext/S0092…
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Very happy to have been awarded the NSF GRFP. This would not have been possible without the people who provided help and training along the way. Many thanks to everyone, especially Karen @AdelmanLab, Danesh @Moazed_Lab and Craig @craigedit.
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Three rules for epigenetic inheritance of human Polycomb silencing biorxiv.org/content/10.1101/…
Three rules for epigenetic inheritance of human Polycomb silencing

Three rules for epigenetic inheritance of human Polycomb silencing

Heritable expression of developmental genes is mediated by autoregulating transcription factor networks (TFNs) and Polycomb repressive chromatin silencing complexes (PRCs). Whether the mammalian...

biorxiv.org
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Excited to share our recent work on the establishment and epigenetic inheritance of mammalian heterochromatin and the role of DHX9 R-loop resolvase in safeguarding heterochromatin stability. #EpigeneticInheritance, #Heterochromatin, #Rloops #GeneSilencing. biorxiv.org/content/10.1101/…
Requirements for establishment and epigenetic stability of mammalian heterochromatin

Requirements for establishment and epigenetic stability of mammalian heterochromatin

Heterochromatic domains of DNA account for a large fraction of mammalian genomes and play critical roles in silencing transposons and genes, but the mechanisms that establish and maintain these...

biorxiv.org
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Redi Metali retweeted
AdelmanLab (@AdelmanLab) profile picture
AdelmanLab@AdelmanLab11 Aug 2022
Congratulations to the CSHL Gene Ex course for winning the famous plate race! I have been so proud of you all this year - for many reasons- and this just shows that you can do anything you put your mind to! 🎉🙌🏻🍾
Image from AdelmanLab (@AdelmanLab)
Image from AdelmanLab (@AdelmanLab)
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Just received my acceptance letter for the @cshlgnx course. Super excited to be going to @CSHL this summer to learn more about my favorite subject: Chromatin and Epigenetics!
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Latest from @Moazed_Lab nature.com/articles/s41586-0…
Rixosomal RNA degradation contributes to silencing of Polycomb target genes

Rixosomal RNA degradation contributes to silencing of Polycomb target genes

Nature - The rixosome associates with Polycomb repressive complexes and chromatin and has a role in silencing of Polycomb target gene expression in human cells via degradation of nascent RNA...

nature.com
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It’s academics, baby!
Dr. Glaucomflecken (@DGlaucomflecken) profile pictureDr. Glaucomflecken
@DGlaucomflecken22 Jan 2022
Nature does open access
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The @Moazed_Lab is hiring. hhmi.wd1.myworkdayjobs.com/e… hhmi.wd1.myworkdayjobs.com/e…
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Measure success by the joy you get from your work and that what you publish is true!
The Nobel Prize (@NobelPrize) profile pictureThe Nobel Prize
@NobelPrize23 Nov 2021
"I think success is having a career where you enjoy it so much that you almost feel guilty that people pay you to do it because you are having so much fun every day." Wise words by our 2019 medicine laureate William Kaelin who turns 64 today. #NobelPrize

William Kaelin on success

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Congrats @trodriguezUMMS
UMass Chan Medical School (@UMassChan) profile pictureUMass Chan Medical School
@UMassChan1 Dec 2021
MD/PhD student Tomás Rodriguez will be recognized @ the New York Hispanic Health Professional Student Scholarship Gala on Thursday for his work to advance #Latinohealth. Watch to learn about his research & activities. @The_NHHF @NHMAmd @UMassChanSOM @UMassChanGSBS @trodriguezUMMS
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Last night, our preprint on the contribution of #RNAPII on #3Dgenome organization transformed into an article in @ScienceAdvances. This is a piece of work very close to my heart (for multiple, mostly non-scientific reasons); thus, a short thread follows: science.org/doi/10.1126/scia…
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis

Following exit from mitosis, RNA Pol II is required for reestablishing 3D genome folding by loading cohesin complexes onto DNA.

science.org
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In the animal germline, piRNAs silence transposons and regulate host genes. Without piRNAs, animals are sterile. If you want to learn how animals protect and destroy piRNAs, read the latest paper from the Zamore lab. With @cansucolpan5 @zamore_lab. cell.com/molecular-cell/full…
Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability

Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability

piRNAs are an animal-specific class of small RNAs that repress transposons and regulate genes. piRNA biogenesis concludes with 3′ terminal trimming and 2′-O-methylation. Gainetdinov et al. show that...

cell.com
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If the C. elegans community bands together and donates $10k to @DragonflyMH I will get a prominent C. elegans tattoo
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Sending a piRNA manuscript to Phil Zamore feels like taking the prelim.
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Redi Metali retweeted
Moazed Lab (@Moazed_Lab) profile picture
Moazed Lab@Moazed_Lab10 Aug 2021
Would you like to maintain your knowledge of what's new in epigenetics? Then check out our most recent paper on 'A Composite DNA Element that Functions as a Maintainer Required for Epigenetic Inheritance of Heterochromatin' cell.com/molecular-cell/full…
A composite DNA element that functions as a maintainer required for epigenetic inheritance of...

A composite DNA element that functions as a maintainer required for epigenetic inheritance of...

Wang et al. reveal the mechanism of DNA sequence-dependent epigenetic inheritance by showing that a 130-bp composite DNA element with binding sites for three site-specific DNA binding factors acts as...

cell.com
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There are two kinds of scientists
Image from Sarah Paramore, PhD (@parahsaramore)
Image from Sarah Paramore, PhD (@parahsaramore)
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Redi Metali retweeted
Moazed Lab (@Moazed_Lab) profile picture
Moazed Lab@Moazed_Lab22 Jun 2021
Hey #sciencetwitter ... the Moazed lab is here! Follow us for all things chromatin #AcademicTwitter
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