@RutterLab

Official Rutter Lab Twitter | @UUtah | @HHMINEWS | #MitoMonday | #Mitochondria, #Metabolism & other cool stuff. Jared's tweets are signed -JR. Views are ours

 Salt Lake City, UT
rutter.biochem.utah.edu
Joined July 2018
  • Tweets12K
  • Following673
  • Followers9.4K
952Media
Congratulations to our tremendous graduating fellow, @N8Krah, on his newest preprint! Nate will be starting his lab here at @UofUHematology @huntsmancancer. We're excited to continue supporting his research!
Nate Krah
@N8Krah
Sep 5
🧵 the Krah Lab opens this month and our first preprint is live on bioRxiv! This was a highly collaborative project with the Chaix Lab, @Dorrance_Lab and @RutterLab asking: does the modality of weight loss change how blood and inflammatory cells are made? biorxiv.org/content/10.64898…
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Congrats to our amazing postdoc, @luisci22, on being awarded the K99/R00 from the NIGMS!
Luis Cedeño-Rosario, PhD@luisci22
Aug 14
It is NOA day! 🎉 I feel blessed and excited to receive the K99/R00 from NIH NIGMS! Thanks to everyone who has supported me and continues to support me on this journey. I appreciate you all! 🙏🏾✨🧪@UofUBiochem @RutterLab
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We are thrilled to share this new preprint from our awesome grad student, @Tarun579_599! Tarun discovered that mitochondrial membrane proteins have evolved to incorporate threonines in place of highly hydrophobic residues to assist in their transit from the cytosol to mitochondrial membranes.
Tarun Yadav@Tarun579_599
Aug 11
Excited to share our new preprint on how mitochondrial membrane proteins incorporate threonine to balance targeting through the aqueous cytosol with membrane stability. biorxiv.org/content/10.64898…

Sequence adaptations satisfy the constraints of mitochondrial membrane protein evolution

Inner mitochondrial membrane proteins must be sufficiently hydrophilic to withstand aqueous exposure during translation and transit to the mitochondria. Meanwhile, their transmembrane segments must...

biorxiv.org
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Congratulations to our amazing summer undergraduate students on a successful presentation at the @UUtah Undergraduate Research Symposium (URS)! ✨ We are very proud of them and can't wait to see them continue to shine on their scientific journey! 🔬🧬🧪 @UofUBiochem @hhmi_science
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It's a two-fer Tuesday. We are ecstatic to share this preprint from our amazing postdoc @CNFXC. Corey solved a long-standing question in the field of transport biology, identifying SLC16A6 as a melanosomal tyrosine transporter.
Corey N Cunningham@CNFXC
Jul 7
Excited to share our new preprint from @RutterLab, identifying a melanosomal tyrosine transporter! biorxiv.org/content/10.64898…

SLC16A6 is a tyrosine transporter for the melanosome

Cells enable specialized metabolism by compartmentalizing metabolic pathways into distinct organelles, which requires the membrane transport of metabolites. In melanocytes, the amino acid tyrosine is...

biorxiv.org
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The field has sought this factor since the 90s. Detective Cunningham on the case, see the tweetorial!
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We are excited to share a new preprint from our amazing postdoc @alexjbott ! Alex designed a new CRISPR screening platform called TRoUT-FISH to identify transcriptional activators and repressors of various genes of interest! Check out his tweetorial below!
Alex Bott@alexjbott
Jul 7
Happy to share our new preprint from @RutterLab. To understand how genes are controlled, we developed a method we call TRoUT-FISH, using CRISPR + RNA-FISH. We found that glycolytic gene expression is fine-tuned by lineage specifying transcription factors. biorxiv.org/content/10.64898…

Lineage specifying transcription factors determine cell function by direct control of metabolism

Execution of a complex cellular function requires the coherent expression of a set of genes that encode the requisite biochemical program. It is believed that this is typically accomplished by...

biorxiv.org
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This is a bit of a tale of two stories: we’re deeply intrigued by the biology and we think that this method is incredibly useful. It fills a gap in the field to ask gene-centric regulatory questions. We hope you enjoy the preprint, reach out with feedback!
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Congrats to our superstar postdoc, @narbonaperez, for being awarded a UMDF Postdoctoral Fellow Grant! #Congrats #MitoMonday #UMDF 🎉🎉🎉 Many thanks to @UMDF for supporting Alvaro's promising work!
United Mitochondrial Disease Foundation@UMDF
Jun 16
UMDF and @AusMito congratulate all of the 2026 Research Grant Award recipients! Read our full announcement to learn more about how this research will help advance the field of #mitochondrialdisease research. umdf.org/research-grant-awar…
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Two for Thursday: We want to highlight another fantastic collaboration, this time with William Oldham's lab at Brown University and our @N8Krah, demonstrating that MCT4 is a druggable target in pulmonary fibrosis. Check it out here: science.org/doi/10.1126/scit… @UofUHematology @huntsmancancer Congrats to everyone involved!

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental...

Lactate transport inhibitors reprogram fibroblast metabolism to prevent myofibroblast differentiation and reduce pulmonary fibrosis.

science.org
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We want to highlight a new collaborative project, led by @yliu_UofU lab with help from our superstar @UofUHematology Fellow @N8Krah, on the implementation of a novel CRISPR-Cas system to selectively kill cancer cells! #RisingStar #CRISPR
Nate Krah
@N8Krah
May 6
🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵
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Exciting news from the @RutterLab! Our amazing lab techs got accepted into graduate school! "Congrats to Christina (@ChristinaVolz22) and Zihan (@ZMonshad). We're excited to watch them continue their science journey!" -JR @UofUBiochem @UUHSResearch @hhmi_science 🧪🎉
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We are excited to announce that our recent collaborative paper, led by the superstar duo Rebekah Nicholson and Luis Cedeño-Rosario, which identified how ceramides alter mitochondrial structure and function after acute kidney injury was selected to participate in #STATMadness! Check it the press release here: tinyurl.com/y2pk2tcy Vote daily at: statnews.com/feature/stat-ma…

New Drug Protects Mitochondria and Prevents Kidney Injury in Mice

If the drug works in people, it could prevent kidney injury in high-risk populations, or potentially even treat other diseases that affect mitochondria, like heart failure and diabetes.

healthcare.utah.edu
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Starting the 2026 with excellent news! Congratulations to graduate students Queren Alcantara (@queren_alcca) and James Carrington for receiving the AHA Predoctoral Fellowship! @AHAScience @UofUBiochem @hhmi_science 🔬🧪🌟
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Happy Holidays from the @RutterLab! 🎄🎅 📷 credit: Katarina Heyden and Tarun Yadav. @UofUBiochem @hhmi_science
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#RedoxBio25 kicked off yesterday with a fantastic opening talk from Jared Rutter (@RutterLab) on “Evolution of Metabolic Regulation.” A great start to an exciting conference!
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Happy Halloween from the Rutter Lab! 👻🎃
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We are excited to announce our 2025 @UofUDMRC Postdoctoral Rising Stars in Metabolism Symposium! This is truly a unique opportunity to network, present your research, and enjoy the breathtaking views that Salt Lake City has to offer. Deadline is May 15th, 2025. Please share!
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A seriously awesome event (despite my tardy post)!! Thanks @NYASciences, @nyugrossman, fellow organizers (@lydfinley, @MarcusDGon), the *speakers for sharing awesome (and unpublished) science, and the attendees for literally packing the house! (Every seat reserved) 😃 *Speakers: @KivancBirsoy, @Chiolaboratory, @HaigisLab, @IntlekoferLab, @ThalesPapaG, @RutterLab, @DanWahlMD, @EileenWhitePhD
Lydia Finley@lydfinley
9 Apr 2025
Grateful for another day of outstanding science at the cancer metabolism symposium @NYASciences. Feeling lucky to see so much amazing basic and translational metabolism work over 10 years of symposia with this guy @LyssiotisLab. Here’s to the next 10 years of metabolism research!
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