Interested in everything related to inositol, phosphate, and inositol pyrophosphates from the origin of life to the development of multicellular organisms.
London
Joined December 2019
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simple, small, and mighty
Human plasma inositol hexakisphosphate (InsP6) phosphatase identified as the Multiple Inositol Polyphosphate Phosphatase 1 (MINPP1) doi.org/10.17912/micropub.bi…
The inositol phosphate signalling network in physiology and disease sciencedirect.com/science/ar…
The role of inositol in the environmental organic phosphate cycle sciencedirect.com/science/ar…
A mammalian model reveals inorganic polyphosphate channeling into the nucleolus and induction of a hyper-condensate state: Cell Reports Methods cell.com/cell-reports-method…
Congratulation to Tatiana for her nice work.
Phosphate overplus response in Chlamydomonas reinhardtii: Polyphosphat... sciencedirect.com/science/ar…
The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal... : Journal of the American Society of Nephrology journals.lww.com/jasn/abstra…
Biochemical and structural characterization of an inositol pyrophosphate kinase from a giant virus | The EMBO Journal embopress.org/doi/full/10.10…
Interesting thoughts are expressed here.
Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology portlandpress.com/biochemsoc…
Check how redox signaling regulates PP-IPs levels.
β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner | PNAS pnas.org/doi/10.1073/pnas.23…
Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system jbc.org/article/S0021-9258(2…
Fantastic work by Masatoshi Ito and collegues. The uniqueness of intestinal PP-IPs metabolism is an exciting discovery.
HIV-1 needs the cell metabolite IP6 to build its capsid and infect cells www2.mrc-lmb.cam.ac.uk/hiv-1…
Another fantastic work by Leo and his collaborators
Regulations of myo-inositol homeostasis: Mechanisms, implications, and... sciencedirect.com/science/ar…
Great work by Masatoshi Ito and colleagues
Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system biorxiv.org/content/10.1101/…
saiardi_lab retweeted
Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system biorxiv.org/cgi/content/shor… #bioRxiv
An exciting work liking inositol pyrophosphate to kinetochore functions
Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe mdpi.com/1810448 #mdpijof via @JoF_MDPI
Congratulation to Minh and all the other co-authors for revealing an inositol phosphate unexplored (until Minh work) pathway.
Stable isotopomers of myo-inositol to uncover the complex MINPP1-dependent inositol phosphate network biorxiv.org/content/10.1101/…
saiardi_lab retweeted
New Publication: Congratulations to the authors. This work identified role of plant Inositol Pyrophosphate Kinase (VIH) in modulating the expression of cell-wall homeostasis genes, and tolerance to water-deficit stress.@DBTIndia @BMCBiology
bmcbiol.biomedcentral.com/ar…
Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response cell.com/cell-reports/fullte…
Finally some explanation of the complex social amoeba inositol pyrophosphate metabolism.
The inositol pyrophosphate metabolism of Dictyostelium discoideum does... sciencedirect.com/science/ar…