The Science of Parkinson's

An exploratory longitudinal multi-cohort study explored the pattern of cognitive decline in GBA1-associated #Parkinsons. Pathological variant carriers performed worse in executive function, attention, visuocognitive skills, & memory vs non-GBA1-PD cases onlinelibrary.wiley.com/doi/…

New findings suggest that glymphatic dysfunction is associated with worse motor & cognitive function in #Parkinsons & may exert stronger effects when striatal dopamine is severely depleted; N=207 patients with newly diagnosed PD nature.com/articles/s41531-0…

Researchers identified the rare TMEM175 variant p.L275R in a patient with early onset #Parkinsons. They find the mutant proteins loses proton- & agonist-dependent activation gating. TMEM175 activation restored lysosomal functions &⬇️α-synuclein aggregation jci.org/articles/view/206733

Researchers investigated target-specific beta activity in Local Field Potentials recorded in #Parkinsons patients implanted with sensing-enabled STN- or GPi-DBS & examined differential modulation by L-Dopa & stimulation & relationship with motor symptoms nature.com/articles/s41531-0…

Teva Pharmaceuticals announces discontinuation of the Phase 2 TOPAS-MSA study of emrusolmin (aka TEV-‘286; Anle138b) following interim futility analysis by the independent data monitoring committee. 350 multiple system atrophy participants treated 48 weeks ir.tevapharm.com/news-and-ev…

Researchers report that thrombin, a serine protease associated with inflammatory conditions, selectively cleaves #Parkinsons-associated α-Synuclein at Lys6–Gly7, generating a 7–140 fragment despite the presence of multiple potential cleavage sites nature.com/articles/s41467-0…

A multimodal neuroimaging study analyzing neuromelanin & iron brainstem content in #Parkinsons identify nigrosome-1 as the main subregion where multimodal MRI captures the PD-related nigral degeneration; iPD & GBA1-PD difference nature.com/articles/s41531-0…

Using longitudinal blood-based proteomics from 166 patients, researchers propose progression-specific molecular signatures in #Parkinsons; Higher CD276 & POSTN associated with worse MDS-UPDRS2, while higher VEGF-C & IL19 associated with worse MDS-UPDRS3 nature.com/articles/s41531-0…

Researchers identify adenosine deaminase 2 (ADA2) as a key regulator of mitochondrial quality control that prevents organelle dysfunction & limits inflammation driven by aberrant IFN signaling nature.com/articles/s41418-0…

Results of a randomized crossover trial comparing 8-week Mediterranean-ketogenic vs medium-chain triglyceride-supplemented Mediterranean diets in 52 people with #Parkinsons (NCT05469997) finds neither approach markedly alters the gut microbiome cell.com/iscience/fulltext/S…