Merck Associate Principal Scientist - Biocatalysis 🧬🧪🧫. Figure Skater ⛸
Connecticut, USA
Joined October 2017
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Scott France retweeted
Congratulations to the seven 2025 ACS Pride Merck Graduate Research Award recipients! Read more here: tinyurl.com/MerckPROF
Stay tuned for more information as the seven will speak at the 2025 ACS Spring Meeting in San Diego.
#QueerInSTEM #STEMPride #ResearchExcellence #Award
ALT Seven headshots of the 2025 recipients of the ACS Pride Merck Graduate Research Award are shown on a tan background with their names, pronounces, and institution are displayed. Additionally, the Merck green and gray name logo are shown under the "sponosred by" byline. The ACS PROF Divsion and Pride subdivision logos are also on the graphic.
Scott France retweeted
Amazing news for the world of #proteins, #enzymes , #chemistry and #biocatalysis! Great day for science!
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Scott France retweeted
Accelerating enzyme engineering: In @nchembio we show that by removing destabilizing mutations from sequence space we generated a🚀Kemp eliminase in only 5 evolution cycles! Recombination charts the designer enzyme's fitness landscape🏔️.
👉nature.com/articles/s41589-0…
@NCCR_Catalysis
Scott France retweeted
Check out our new work led by the amazing Dr. Ye Wang in @J_A_C_S! We are so proud of this wonderful team and their investigation into the PLP radical!
pubs.acs.org/doi/10.1021/jac…
Thoroughly enjoyed the 2024 #Biocatalysis #GRC! Great job @FlitschSabine and Carlos Martinez. Bring on the 2026 meeting with me and Dörte Rother as vice-chairs! Very excited to work with chairs @sBiosChem and Radka Snajdrova as well as GRS chairs @hairofthehogg and @MaxGantz_!
Scott France retweeted
Great talk from Kevin Maloney @Merck on highly efficient, low-waste #enzyme cascade production of pharmaceuticals. #directedevolution #ECC9 #EuChemS2024 This is the sustainable future of #chemistry.
We’re learning about the real world impact of @francesarnold incredible directed evolution research in @Merck drug development @EuChemS_Congres in Dublin 🤯💚🧬
#9ECC #NobelPrize
Scott France retweeted
Excited that the final version of our work using lysine as a smart donor to prepare branched arylalanines is in @J_A_C_S today! Amazing work by @NoahPDunham and everyone who worked on this! #MerckChemistry @RayRitwika @RBWormwood @yining_RPKA @mreibarkh
pubs.acs.org/doi/10.1021/jac…
Scott France retweeted
Wild-type transaminases, a lysine smart donor, and a great scope of noncanonical amino acids, out today in @J_A_C_S (pubs.acs.org/doi/10.1021/jac…).
All thanks to a crack team!
@asymtmm, @RBWormwood, @RayRitwika, @yining_RPKA, @mreibarkh
Scott France retweeted
Self-recycling imine reductases? Yes please! Congrats to the Novartis team for turning a promiscuous Glucose Dehydrogenase into an IRED #biocatalysis #proteinengineering #greenchemistry | ACS Catalysis pubs.acs.org/doi/10.1021/acs…
Scott France retweeted
Great to see that Merck has taken interest in this DKR process that we discovered a few years ago. They also expanded the reaction scope to bulkier ncAAs and products with trans (2S,3S) configuration
Lysine an amine donor in transaminase-catalyzed reactions?
A thrifty hack for driving equilibria!
chemrxiv.org/engage/chemrxiv…
Lysine - a new addition to the transaminase ‘smart’ amine donor collection! Check out the latest work from the Merck team! #merckchemistry #biocatalysis
Lysine an amine donor in transaminase-catalyzed reactions?
A thrifty hack for driving equilibria!
chemrxiv.org/engage/chemrxiv…
Scott France retweeted
Really great work by the team to avoid issues around byproduct removal associated with transaminases and develop lysine as a smart donor, plus a great scope of noncanonical branched arylalanines! #MerckChemistry @NoahPDunham
chemrxiv.org/engage/chemrxiv…
Scott France retweeted
Exciting news! I’m looking to hire a Senior Scientist to join our growing Discovery Process Chemistry group in London! 🇬🇧Same posting allows includes Discovery positions - double bonus!
Application link below 👇👇
#MSDChemistry #UKChemJobs
jobs.msd.com/gb/en/job/R2850…
Scott France retweeted
Exciting bioinformatics job opening in our department.
jobs.merck.com/us/en/job/R28…
Was a pleasure to co-lead this year’s installment of the “Synthetic Approaches…” series! Check out the article here!
Synthetic Approaches to the New Drugs Approved During 2022 | Journal of Medicinal Chemistry pubs.acs.org/doi/abs/10.1021…
Scott France retweeted
Mentoring circles are back ✨ Don’t miss this awesome opportunity to network!
Mentoring circles are back again ⏪ Come expand your network and grow your support system 👩🔬 Sign up using the link below 👇 by April 15th #WomeninSTEM #Mentorship
Link: docs.google.com/forms/d/12b_…
Scott France retweeted
With smart engineering techniques, we boosted ketoreductase activity for ipatasertib precursor synthesis by 64-fold. Algorithmic help shrunk library size, ensuring efficiency. Result? ≥98% conversion rate with 99.7% de!🌿🧪
👉rdcu.be/dzTZN
@CommsChem @NCCR_Catalysis
Scott France retweeted
Our third episode of the season is here! Check it out on your favorite platform or visit our show page at anchor.fm/pharm-to-table
#MerckChemistry
Scott France retweeted
Congratulations @drgauthi, collaborators @Merck and our team for work out in @NatureChemistry showing functional group metathesis between in situ chlorinated carboxylic acids can offer a straightforward approach to carbon isotope labelling @McGillChemistry nature.com/articles/s41557-0…