SynBioLab

In collaboration with @SDumanliOktar Lab we have engineered bacteria to gather physiological information and transmit it through an in-body antenna, enabling real-time health monitoring. Our work is now published in Nature Communications @NatureComms. nature.com/articles/s41467-0…

We are proudly celebrating Dr. Merve Erden's @MerveTucer PhD degree. Merve has worked on transcriptomics analysis of the toxicity of various nanoparticle on healthy liver cells with indentation of hunting new biomarkers for developing synthetic gene circuits to develop +

We are happy to announce the graduation of Cem D. Polat from M.Sc program. Cem, showed engineering of PETase and Metase enzymes and displaying these enzymes on cell surface. This work holds a great promise for developing technologies for plastic degradation.

Our lab members have prepared and edited a new book titled "Synthetic Bİology for Therapeutics", it will be published by DeGruyter as a part of their STEM book series. The hard copy of the book will be released on November 18, 2024.

We have designed a microbe to target § destroy breast cancer cells in vitro . We built an attachment circuits displaying a nano body and a destroy module that secrets a shiva-toxin to attack tumor cell membrane. the paper is published in @ACSSynBio pubs.acs.org/doi/full/10.102…

Antimicrobial resistance (AMR) is a global threat. Using synthetic biology we have engineered secreted biofilm proteins with antibiotic degrading enzymes : "An Antibiotic-Degrading Engineered Biofilm Platform to Combat Environmental Antibiotic Resistance" pubs.acs.org/doi/full/10.102…

We are happy to announce the PhD graduation of our group member @synbiolab Merve Yavuz @mymerveyavuzmy ! She has successfully defended her thesis titled "Genetically Designed Microbes for Bioimaging and Biosensing". #syntheticbiology #biosensing Congratulations! 👏👏👏

Cellulose binding protein enhances the attachment of the bacterial biofilm protein and provides a secure environment for the bacteria, this also protects the bacteria agains many harsh conditions including high temperature and acidity.

In our recent study published in "Biosensors and Bioelectronics" we engineered E. coli to detect heavy metals on paper based platform. To ake the cells attach on the paper, we genetically fused a cellulose binding protein from Cellulomonas fimi sciencedirect.com/science/ar…

Today our lab member @ecceavcci has successfully defended her master thesis on developing CRISPR/Cas-13 based therapeutic strategies for Crimean-Congo Hemorrhagic fever disease by targeting CCHF Viral genomic material. She has completed in vitro part and now running the in vivo !

We have extended our capabilities for peptide drug discovery for antiviral-peptides using our innovative screening approach. Our case study for whole-Sars-CoV-2 virus has been published in ACS Pharmacology and Translational Science shorturl.at/cLMQ0

Glycosylation is a critical post-translational modification which is barely available in bacteria. Here we have presented and engineered genetic circuit for the glycosylation of proteins for enhanced catalytic properties.Gycosylation dramatically enhanced+ pubs.acs.org/doi/full/10.102…

We have developed a system for drug screening against non-soluble protein targets in neurodegenerative diseases. The work has been accepted for publication in @ACSChemNeurosci and will be highlighted on the cover

In our recent preprint @SekerLab we have developed an inducible leaky outer membrane-based secretion system for recombinant protein secretions in Gram negative bacteria for living therapeutics and microbial cellular therapeutics. We engineered a small RNA molecule triggered+

Our cells have docked on breast cancer spheroids via a HER2 specific nano body, after docking the cells bacteria started to secrete HlyA protein in fusion with YebF protein. And finally with the pore forming effect of HlyA protein triggered the death of the JIMT1 cells.

Our latest on developing bacterial living cancer therapeutics using synthetic genetic circuits is in pre-print now. We equipped bacteria with a tumor targeting antibody and a drug delivery tool to deliver a pore forming toxin. #syntheticbiology

We have developed a system for drug screening against non-soluble protein targets in neurodegenerative diseases. we engineered yeast cell surface to display the target protein in a suspended form while we used a PD peptide library to screen for candidates nitter.cf/biorxiv_neursci/status…

Synbiolab had a great 2022, completed many high impact work, developed innovative research ideas and have many studies highlighted on journal covers! We wish a happy new year to everyone!