General Surgery Resident🪡@UniPadova @HPDsurgery 🇮🇹 Currently fellow at Karolinska Insititutet 🇸🇪 - Born in Reggio Calabria
Padova, Veneto
Joined October 2011
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Sergio Postorino retweeted
✋ Discontinuing surveillance of Trivial IPMN is safe! Out in @UEGJournal
👍 25% would be discharged / No HGD missed!
💸 Money saved depend on local health care system
🍇 Prospective evaluation ongoing with @MarcBesselink @DeMadaria and others 🙋🏼♂️
onlinelibrary.wiley.com/doi/…
Sergio Postorino retweeted
🇮🇹 Pancreatic cancer in Italy: what will 2035 look like?
📈 >13% increase in deaths
👴 Driven largely by population aging
⚠️ But with a striking North–South divide in mortality trends.
👉Forecasting disease burden is healthcare planning👈
link.springer.com/article/10…
Sergio Postorino retweeted
🔴🔴During the past few days we had the enormous pleasure to host the first surgical residents led conference, dedicated to other residents and medicine students 🏆 ResidentX!
🎓 Together with guests 🇺🇸 like @cwolfga2 we warmly welcome the 32 new residents in general surgery!
Sergio Postorino retweeted
😨 If you do pancreas surgery you do FEAR chronic corticosteroid therapies…
🇮🇹🇺🇸🇳🇱🇯🇵 2.5k patients matched per therapy
💊Chronic steroids led to ⬆️ morbidity, mortality (10%!) and infections
🔴 Risk stratification should be balanced accordingly!
sciencedirect.com/science/ar…
Sergio Postorino retweeted
How to manage chronic corticosteroid therapy before pancreatic surgery?
🔥 Increased morbidity burden and 5× higher mortality
🗣️ Preoperative counselling is essential
🤝 Multidisciplinary, risk-adapted perioperative planning
sciencedirect.com/science/ar…
Sergio Postorino retweeted
🛸 The future of integrated treatment for pancreas cancer
💉 FOLFIRINOX and gem–nab have shaped modern systemic therapies
✂️ MI surgery + vascular resection expanded surgical options
👉 but future... will speak #kras inhibitors language!
dldjournalonline.com/article…
Sergio Postorino retweeted
Surgical drawing is
NOT an artistic skill
but a SURGICAL one.
Come learn it IN PERSON from the true masters: 🇯🇵 Japanese HPB surgeons
(both hand AND digital drawing!)
📆Oct 29 @IHPBA ECG retreat
Register here tinyurl.com/yc84sfnb
✍️ Do you sketch your preoperative plan? Study the anatomy, visualize the operation, turn it into a surgical drawing. Learn with our expert Japanese instructors 🇯🇵🌎
🖊️Hand or digital drawing both welcome!
📅 Oct 28 at the IHPBA ECG Retreat
🔗Register: tinyurl.com/yc84sfnb
Sergio Postorino retweeted
Pancreatic cancer surgery in Italy 🇮🇹outcomes by hospital volume
🏥 3.4k surgeries / 90day mortality 10%
🔴 <30 surg - mortality > 10% = 21%
🟡 30-50 surg - mortality >5% = 18%
🟢 >50 surg - mortality <5% = 61%
📣 Pancreas unit urgently needed 📣
link.springer.com/article/10…
Sergio Postorino retweeted
🍒 Small p-NET <2cm always a challenge
🇮🇹 🇯🇵 🇫🇷 🇹🇷 🇬🇧 🇩🇪 460 resected / 35% enucleation
⚠️ Central panc morbidity 25% 🆚 enucleation 10% and ⬆️ POPF / LOS
🫐 LN Mets 14% 🙃
My take: less (no surgery) is MORE!
onlinelibrary.wiley.com/doi/…
Sergio Postorino retweeted
Of surgical dogma and lemonade 🍋 managing the drain left after pancreatoduodenectomy
✍️ Beautiful commentary by @HalletJulie in @BjsOpen a pleasure to read!
↓↓↓
academic.oup.com/bjsopen/art…
🆕 Drain management risk-stratified dynamic algorithm after Whipple 🆕
💦 Drain fluid amylase still key but pathways different based on intraop risk assessment
🚨 800 PD included / 32% high risk
Check out the thread 👉 practice changing algorithm
academic.oup.com/bjsopen/art…
Sergio Postorino retweeted
🥇 Artery first approach in 🤖 robot PD
👉 right or left 👈 ?! But also mesenteric / anterior / posterior
🔴 Still heterogeneity BUT never compromising with safety and oncological radicality 🔴
A stellar ⭐️ session at Japan 🇯🇵 Pancreas Society 👏 in Fukuoka today
Sergio Postorino retweeted
Is this the World Cup 🏆 for PDAC studies?!
💉 First in human #Kras vaccine for PDAC interception in high risk cohort 😱
👮 T Cell response in 90% persisting up to 2 years - no participants developed PDAC
🍿 and now we can enjoy 🇪🇸 🇦🇷 … 😜
aacrjournals.org/cancerdisco…
Sergio Postorino retweeted
Mesopancreas excision ✂️ International consensus
🗺️ Defined as retropancreatic compartment of lymphatic neurovascular and adipose tissue
👍 Both artery- and mesenteric-first approach OK
🧼 Total excision more curative?! to be investigated further
authors.elsevier.com/c/1nQPh…
Sergio Postorino retweeted
💦 Do you use Trans-anastomotic stents to protect your PJ?
🫡 Predictive value of drain amylase 🧪 still valid!
🧯1.1k PD / 40% stents both POD1 POD3 predictive but must integrate with risk factors
sciencedirect.com/science/ar…
Sergio Postorino retweeted
The @EurPancClub in 🇹🇷 has been a 💥
🥇Solid rappresentation of @HPDsurgery with both doctors and nurses as invited speakers
🇮🇹 Italy won the bid for 2030 in Milan
💪We salute @lelecapurso stepping down from secretary who did an amazing job
Sergio Postorino retweeted
🎞️ History in the making as the RASolute trial lands in Europe 🇪🇺 for the first time event presented at @EurPancClub 🇹🇷
#Daraxonrasib met all primary and 🔑 secondary endpoints
🙏 to the patients who made this possible, we can now transform the treatment of PDAC
Sergio Postorino retweeted
👏 We are all here, in this standing ovation. We are all there, in that Kaplan–Meier curve.
🫶 The hopes of a community. The legacy of those who came before us, and the responsibility entrusted to those who will follow.
Time will tell. But today, we stand here together 💜
Sergio Postorino retweeted
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM
@ASCO
ALT Graph from a study published in the New England Journal of Medicine on daraxonrasib versus chemotherapy for metastatic pancreatic cancer. The x-axis represents months, and the y-axis shows the percentage of patients alive. Two lines indicate survival rates: daraxonrasib (blue) and chemotherapy (gray). The bottom section lists patients at risk over time. Title and journal logo are included.
Sergio Postorino retweeted
Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer
Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived
#ASCO26
Sergio Postorino retweeted
🔴 Post-Pancreatectomy liver injury (PPLI) might be a new significant entity in the modern era of pancreas cancer surgery with vascular resection
👉 Incidence 13% leading to ⬆️ mortality
🔜 More to come!
sciencedirect.com/science/ar…
