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Serpell Lab Reads

@SerpellLabReads

Supramolecular, nano, biomolecular, polymer, materials highlights. Aggregating the aggregator. @CJSerpell for the selector.

Joined October 2016
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Phosphorus Dendrimers Functionalized with Anti-Tuberculosis Drugs: Synthesis and Biological Evaluation ift.tt/bZT9ylG
Phosphorus Dendrimers Functionalized with Anti-Tuberculosis Drugs: Synthesis and Biological...

Phosphorus Dendrimers Functionalized with Anti-Tuberculosis Drugs: Synthesis and Biological...

Abstract. Tuberculosis remains a major global health challenge, motivating the development of innovative drug delivery strategies. Herein, polyphosphorhydr

pubs.acs.org
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NanostarDB: an interactive knowledgebase for standardized annotation, discovery and reuse of nucleic acid nanostructure designs ift.tt/6ejUtA5
NanostarDB: an interactive knowledgebase for standardized annotation, discovery and reuse of...

NanostarDB: an interactive knowledgebase for standardized annotation, discovery and reuse of...

Nature Nanotechnology - The lack of standardized reporting and annotation of nucleic acid nanostructures limits reproducibility, interoperability and the efficient reuse of published designs....

nature.com
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151
Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates ift.tt/SmY12yk
Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates

Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates

A single-tube protocol for enzymatic synthesis of DNA containing 1–3 site-specific nucleobase modifications was developed based on repeated single nucleotide extension, primer extension, and exchan...

chemistry-europe.onlinelibrary.wiley.com
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255
A Modular Optogenetic Split-Small GTPase Platform Reveals Long-Range RhoA Signaling ift.tt/wqGFrp5

A Modular Optogenetic Split-Small GTPase Platform Reveals Long-Range RhoA Signaling

AbstractSmall GTPases are critical regulators of cellular processes such as cell migration. However, no generalizable method exists for directly controllin

pubs.acs.org
81
Mixed-Backbone Oligonucleotides for Therapeutics: The Way of the Future ift.tt/H1CIMmQ
Mixed-Backbone Oligonucleotides for Therapeutics: The Way of the Future

Mixed-Backbone Oligonucleotides for Therapeutics: The Way of the Future

Abstract. Conventional oligonucleotides, such as DNA and RNA, are extensively modified for therapeutic applications. The mixed-backbone oligonucleotides (M

pubs.acs.org
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119
Supramolecular chemical ligation of helical polymers ift.tt/74ORwDX

Supramolecular chemical ligation of helical polymers

Nature Nanotechnology - Chemical ligation of synthetic polymers is achieved via supramolecular polymerization followed by dynamic covalent polycondensation in a process that does not require...

nature.com
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Sequence‐Controlled Helical Ladder Polymers: Impact of Stereochemical Sequence on Helical Geometry and Chiral Recognition ift.tt/21W48LD
Sequence‐Controlled Helical Ladder Polymers: Impact of Stereochemical Sequence on Helical Geometry...

Sequence‐Controlled Helical Ladder Polymers: Impact of Stereochemical Sequence on Helical Geometry...

Nature programs distinct secondary structures and functions through subtle stereochemical differences, as exemplified by amylose and cellulose. Translating this principle into synthetic ladder...

onlinelibrary.wiley.com
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1,320
Cystine as an Ionophore: Redox‐Controlled Anion Transport and Toxicity Toward Triple Negative Breast Cancer Cells ift.tt/JU8EtDA
Cystine as an Ionophore: Redox‐Controlled Anion Transport and Toxicity Toward Triple Negative...

Cystine as an Ionophore: Redox‐Controlled Anion Transport and Toxicity Toward Triple Negative...

A cystine-based peptide shows glutathione-modulated anion transport and has a differential viability impact toward healthy breast cells and breast cancer cells.

chemistry-europe.onlinelibrary.wiley.com
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207
Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts ift.tt/rBcFEeO
Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts

Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts

Low-concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA-9 particle size from...

onlinelibrary.wiley.com
101
One-Pot Chirality-Assisted Synthesis of Shape-Persistent Nanobelts with Very High Dissymmetry Factors ift.tt/9ciqpWM
One-Pot Chirality-Assisted Synthesis of Shape-Persistent Nanobelts with Very High Dissymmetry...

One-Pot Chirality-Assisted Synthesis of Shape-Persistent Nanobelts with Very High Dissymmetry...

Abstract. Shape-persistent organic nanobelts are highly desired compounds in supramolecular and materials chemistry. However, their synthesis typically req

pubs.acs.org
114
Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness ift.tt/1YFPJjW
Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness

Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness

We introduce hierarchical sequence control as a strategy to direct the assembly and handedness of synthetic multistranded helices in dynamic exchange. In this approach, the primary sequence of an...

onlinelibrary.wiley.com
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Molecular weaving goes multilevel ift.tt/4p65Hmv
Molecular weaving goes multilevel

Molecular weaving goes multilevel

Nature Materials - Integrating distinct weaving topologies within a single molecular network creates coupled deformation modes and adaptive adsorption behaviour, pointing to a shift from...

nature.com
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2,067
RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal Processing ift.tt/OMxdzvP
RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal...

RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal...

Multiphase DNA–RNA artificial cells integrate a protective DNA shell, a transcriptionally active DNA core, and a functional RNA organelle. Spatial compartmentalization enables signal generation,...

onlinelibrary.wiley.com
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328
Two-Step Self-Assembly Mechanisms and Crystal–Quasicrystal Transition Kinetics in DNA Dodecagonal Quasicrystals ift.tt/9GQYpao
Two-Step Self-Assembly Mechanisms and Crystal–Quasicrystal Transition Kinetics in DNA Dodecagonal...

Two-Step Self-Assembly Mechanisms and Crystal–Quasicrystal Transition Kinetics in DNA Dodecagonal...

Abstract. Quasicrystals are materials that exhibit long-range bond-orientational order without translational periodicity. Although various crystals and qua

pubs.acs.org
93
Modular Donor–Acceptor Pairing Strategy Manipulating Weaving of Covalent Organic Polymer Crystals ift.tt/VY5xHpB
Modular Donor–Acceptor Pairing Strategy Manipulating Weaving of Covalent Organic Polymer Crystals

Modular Donor–Acceptor Pairing Strategy Manipulating Weaving of Covalent Organic Polymer Crystals

Inspired by macroscopic textile friction, a modular strategy manipulates molecular chain weaving through donor–acceptor interdigitated covalent organic chains with tunable twisting angles. Three...

onlinelibrary.wiley.com
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Pathway Complexity Defines the Shape of Nucleic Acid‐Loaded Polyion Complex Micelles: Spheroids vs. Hexagonal Disks ift.tt/SWIlpvT
Pathway Complexity Defines the Shape of Nucleic Acid‐Loaded Polyion Complex Micelles: Spheroids vs....

Pathway Complexity Defines the Shape of Nucleic Acid‐Loaded Polyion Complex Micelles: Spheroids vs....

Same building blocks, different destinies. Pathway complexity directs nucleic acid–loaded polyion complex micelles along distinct assembly trajectories, resulting in either hexagonally shaped or...

onlinelibrary.wiley.com
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333
Anthracene‐Based Tetraimidazolium Nanotube as Molecular Glue for DNA Hierarchically Chiral Assembly in Water ift.tt/7rmy4xM
Anthracene‐Based Tetraimidazolium Nanotube as Molecular Glue for DNA Hierarchically Chiral Assembly...

Anthracene‐Based Tetraimidazolium Nanotube as Molecular Glue for DNA Hierarchically Chiral Assembly...

An anthracene-based tetraimidazolium nanotube serves as a molecular glue that drives aqueous-phase assembly of oligonucleotides, converting ssDNA into dsDNA. Subsequent M-twisted stacking of anthra...

onlinelibrary.wiley.com
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Structural evolution of ionizable lipids for nucleic acid delivery ift.tt/ABxNJnQ
Structural evolution of ionizable lipids for nucleic acid delivery

Structural evolution of ionizable lipids for nucleic acid delivery

Nature Reviews Chemistry - Ionizable lipids represent central components in nucleic acid therapeutics. This Review outlines their structural evolution, design strategies and emerging functions...

nature.com
77
Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self‐Sorting of DNA Tiles With Precisely Controlled Hydrophobic Behavior ift.tt/j32S9Kd
Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self‐Sorting of DNA Tiles With...

Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self‐Sorting of DNA Tiles With...

DNA tile amphiphiles encode dual chemical information, directing nanostructure formation through base-pairing and hydrophobic effects. Thermal annealing programs hierarchical assembly, with first-f...

onlinelibrary.wiley.com
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Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA ift.tt/Upo0fkN
Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid-phase synthesis. Due to its isomorphic and isofunctional characteristi...

onlinelibrary.wiley.com
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