Aimee Shen’s lab at Tufts University. C. difficile spore formation, germination and other cool stuff! Committed to increasing diversity in STEM
Boston, MA
Joined October 2018
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Very excited to share this beautiful story by @ShailabShrestha describing his surprising discovery that cell division in C. difficile occurs via a mechanism distinct from previously characterized bacteria. Done in collaboration with the amazing @SGribaldo & Najwa Taib. 1/9
So excited to finally share this work!!
We found an unexpected repurposing of canonical division enzymes during the evolution of endospore formation and some surprisingly unique aspects of cell division in C. difficile.
Check out our preprint: rb.gy/j5uvc
Shen Lab retweeted
@felixrl_ took on a ~50-yr-old mystery in #Staph aureus cell biology and came out on top! Check out his paper on how #Staphylococcus aureus chooses its cell division plane, how it forms clusters, and why all this matters during infection...
nature.com/articles/s41564-0…
Shen Lab retweeted
Our 2024 #S2P2 #symposium at @tuftsgsbs last week was a tremendous #success!
Seeing so many familiar faces and learning about their #career journeys was truly inspiring.
We look forward to seeing you next year!
#s2p2 #keynotespeaker #careerpanel #deiinstem #alumni #oraltalks
Registration deadline is July 25! So looking forward to hearing from our distinguished alumni and Dr. Cornelius Taabazuing at this inspiring event!
Shen Lab retweeted
The Tufts 3rd Annual Summer Symposium @ Pipeline Programs is rapidly approaching. Don't miss the chance to hear inspiring stories from our amazing pipeline program alumni and keynote speaker Dr. Cornelius Taabazing building diversity and excellence in the biomedical sciences.
Shen Lab retweeted
A phosphorylation signal activates genome-wide transcriptional control by BfmR, the global regulator of Acinetobacter resistance and virulence. dlvr.it/T8QKDF
Shen Lab retweeted
Excited to share our recent pre-print! The Vibrio cholerae encoded Nezha anti-phage system (SIR2-HerA) restricts virulent vibriophages ICP1, ICP2, and ICP3 by depleting NAD+ (Abi💀). However, an ICP1 isolate can overcome this by encoding putative NAD+ regenerating proteins! ⚡️
A Vibrio cholerae Anti-Phage System Depletes Nicotinamide Adenine Dinucleotide to Restrict Virulent Bacteriophages biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Shen Lab retweeted
Following up our Cell Reports paper, an avirulent C. difficle clinical isolate out-competes virulent strains in mice via quickly depleting multiple amino acids, and protects mice from developing colitis!
Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain biorxiv.org/cgi/content/shor… #bioRxiv
Shen Lab retweeted
What a thread from @mfgrp . I can go into all the ways I have fallen short here, and also (luckily) where serendipity helps and can be an important driver of project choice.
How to pick a problem. Today in @CellCellPress. 1/53
cell.com/cell/fulltext/S0092…
Shen Lab retweeted
We have a new paper out in @ISMEJournal !
Linking methanotroph phenotypes to genotypes using a simple spatially resolved model ecosystem
academic.oup.com/ismej/advan…
Shen Lab retweeted
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile biorxiv.org/content/10.1101/…
Shen Lab retweeted
How does a progenitor cell differentially express genes in daughter cells after asymmetric division?
@Sylvia_Char 's fancy microscopy in her paper @PNASNews says the division machinery itself positions a transcription activator asymmetrically! pnas.org/doi/10.1073/pnas.24…
Shen Lab retweeted
Happy Feb 1st!💞
Join us burst 💥with excitement like a phage in lysis cuz 😁:
BBM 2024 is now open for registration!
It's the 30th bday of BBM 🎂 🎈 🎉! Where were you in 1994? (I was a newborn with the 🎁 of a microbiome 🦠 😝)
bostonbacterial.org/registra…
See you all there!😎
Shen Lab retweeted
2/2 Dr. Abdul-Mutakabbir was recognized for her research in mitigating AMR by @ECCMID as one of 30 under 30 outstanding young scientists. Among many other honors, she was also the 2023 recipient of the @IDSAInfo's Clinical Practice Innovation Award. MORE: tuftscimar.org/event/the-int…
Shen Lab retweeted
We have a new story out at BiorXiv! Amazing work led by @za_curtis (Bisson), Pedro Escudeiro (Alva) and John Mallon (Bisson).
Great collaboration with @Vikram_Alva (Max Planck) and @pohlschr (UPenn).
A summary of our findings in the thread (1/22)
shorturl.at/fLPR1
Shen Lab retweeted
I am still looking for postdocs to join my lab. I have several NIH-funded positions to work either on Acinetobacter pathogenesis or OMV biogenesis in Bacteroides. Please RT.
Shen Lab retweeted
BrrRRrr! ❄️☃️It's cold out! Even COOLER news:
SAVE THE DATE 🗓️📢
BBM 2024 will be held June 3-4th, 2024 at the Boston University campus! This year will be the 30th anniversary🔥 feat. keynote speaker @joeBondyDenomy🇨🇦of UCSF who studies the coolest phages😎❄️ around!
Shen Lab retweeted
If there was only one scientific practice I could teach to every scientist regardless of stage or field I think it would be: look at the data. Spot check it. Find a few data points and trace them through to see if they make sense. Look at the raw data. Don't just do analyses.
Excited that @twistedbacteria, Editor @NatureComms, highlighted @shailabshrestha's finding that C. difficile (and other clostridial organisms?) mediate division in the absence of FtsW-FtsI homologs. In collaboration with @sgribaldo and Najwa Taib nature.com/collections/jedgc…
Call out to this incredible creation by the @Tufts_NgLab for the dept holiday party. A merphage in the wild! The detail is mind-blowing!
Happy holidays! Super fun making this fully edible gingerbread waterbath for our dept holiday party with this amazing group of people! @sciissue_077 @JacobBouchier @mostly_microbes
