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Shiekhattar Lab (@ShiekhattarLab) profile picture

Shiekhattar Lab

@ShiekhattarLab

@SylvesterCancer @Univmiami

 Miami, FL
shiekhattarlab.org/
Joined March 2018
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  • Following228
  • Followers553
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Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)Photo by Shiekhattar Lab (@ShiekhattarLab)
Shiekhattar Lab retweeted
nature (@Nature) profile picture
nature
@Nature12 Aug 2025
Nature research paper: RNA N-glycosylation enables immune evasion and homeostatic efferocytosis go.nature.com/4m6slCP
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Shiekhattar Lab retweeted
Nature Methods (@naturemethods) profile picture
Nature Methods@naturemethods11 Aug 2025
For a quick summary, read the Research Briefing here: nature.com/articles/s41592-0…

MAPIT-seq reveals both RBP targets and transcriptome-wide gene expression profiles

Nature Methods - We present MAPIT-seq, a method that uses antibody-directed RNA editing to concurrently profile in situ RNA-binding protein (RBP)–RNA interactions and transcriptome-wide gene...

nature.com
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Shiekhattar Lab retweeted
Molecular Cell (@MolecularCell) profile picture
Molecular Cell@MolecularCell8 Aug 2025
Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA dlvr.it/TMNCmm
Image from Molecular Cell (@MolecularCell)
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Our new paper is out on @MolecularCell !! We show that Integrator complex, is essential for RNA Polymerase II recruitment, pluripotency, and developmental gene regulation in mESCs. sciencedirect.com/science/ar… #StemCells #Transcription #DevelopmentalBiology #RNApolII
Image from Shiekhattar Lab (@ShiekhattarLab)
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Honored to contribute to this work with @DrSDNimer. #TAF1 #Hematopoiesis @Dev_Cell @SylvesterCancer
Sylvester Comprehensive Cancer Center (@SylvesterCancer) profile pictureSylvester Comprehensive Cancer Center
@SylvesterCancer25 Jul 2025
🔬 Science meets leadership. As director of Sylvester, @DrSDNimer leads a powerful network of researchers, physicians and patients while continuing his own work in the lab. In his latest study, Dr. Nimer and colleagues uncovered how a key molecule, TAF1, regulates hematopoiesis. Their discovery opens the door to potential new therapies targeting TAF1. ➡️ The findings were published July 16 in @Dev_Cell. Read more: loom.ly/Y9EjgjU
Image from Sylvester Comprehensive Cancer Center (@SylvesterCancer)
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We introduce rPRO-seq, a rapid and low-input method to map nascent RNA with nucleotide precision — in just 12 hours and from as few as 5,000 cells. sciencedirect.com/science/ar… #RNA #Genomics #PROseq #NascentTranscription #Neurodevelopment #MolecularCell
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We also uncover a key role for INTS11 in neurodevelopmental gene regulation.
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Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks biorxiv.org/cgi/content/shor… #biorxiv_molbio
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Explore emerging #CancerEpigenetics #CancerTherapy #Epigenomics research with field leaders @KeystoneSymp Epigenetic Mechanisms and Cancer Treatment, this February in Santa Fe! keysym.us/KSCancerEpi24 #KSCancerEpi24
Image from Shiekhattar Lab (@ShiekhattarLab)
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Hello, check our new paper in BioRxiv. It describes new integrator module (INTS9/INTS11 and BRAT1) regulating the neurodevelopment program.
bioRxiv (@biorxivpreprint) profile picturebioRxiv@biorxivpreprint11 Aug 2023
BRAT1 associates with INTS11/INTS9 heterodimer to regulate key neurodevelopmental genes biorxiv.org/cgi/content/shor… #bioRxiv
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Shiekhattar Lab retweeted
GardiniLab (@GardiniLab) profile picture
GardiniLab@GardiniLab5 Jun 2023
Join us for a FUSION Conference on "Genome Regulation through RNA" next February (11-14) in Cancun! fusion-conferences.com/confe… The meeting will boast cutting-edge work on #epigenomics, #transcription, #lncRNAs & #smallRNAs biology, #genomeintegrity, #epitranscriptomics and more! (1)
Image from GardiniLab (@GardiniLab)
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Shiekhattar Lab retweeted
GardiniLab (@GardiniLab) profile picture
GardiniLab@GardiniLab14 Mar 2023
What can machine learning do for your favorite protein complex? A lot! Especially if paired with proteomics and genomics. In collaboration with @WojtekGalej we characterized the 15th Integrator subunit! Shout out to @offley_sarah and @MorPfl for leading this effort #transcription
Cell Reports (@CellReports) profile pictureCell Reports@CellReports14 Mar 2023
A combinatorial approach to uncover an additional Integrator subunit dlvr.it/SktD5q
A combinatorial approach to uncover an additional Integrator subunit

A combinatorial approach to uncover an additional Integrator subunit

Integrated multiomic approaches, paired with AlphaFold2 modeling, can provide insight into the structure/function of large, multisubunit complexes. Offley et al. characterize C7ORF26 as INTS15, an...

cell.com
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Shiekhattar Lab retweeted
Felipe Beckedorff (@FBeckedorff) profile picture
Felipe Beckedorff@FBeckedorff1 Mar 2023
Interestingly they show H3K4me3 is required to recruit integrator complex, which is essential for the eviction of paused RNAPII and transcriptional elongation.
Lluis Morey (@lluismorey) profile pictureLluis Morey@lluismorey1 Mar 2023
What is the precise role of H3K4me3 in transcriptional regulation? Check out this very interesting new paper from @HelinLab in @Nature nature.com/articles/s41586-0…
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

H3K4me3 regulates RNA polymerase II promoter-proximal pause-release

Nature - Acute loss of H3K4me3 does not have detectable effects on transcriptional initiation, but leads to a widespread decrease in transcriptional output, an increase in RNA polymerase II pausing...

nature.com
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Shiekhattar Lab retweeted
bioRxiv (@biorxivpreprint) profile picture
bioRxiv@biorxivpreprint18 Feb 2023
Human Integrator provides a quality checkpoint during elongation to facilitate RNA polymerase II processivity biorxiv.org/cgi/content/shor… #bioRxiv
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Our new paper is out on @ScienceAdvances The Integrator complex regulates microRNA abundance through RISC loading science.org/doi/10.1126/scia… Well done @kirstein_nina and @SaDo47654137 and all collaborators.
The Integrator complex regulates microRNA abundance through RISC loading

The Integrator complex regulates microRNA abundance through RISC loading

Integrator complex loss resulted in a global miRNA decrease due to defective Integrator-dependent Argonaute protein loading.

science.org
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Shiekhattar Lab retweeted
Nimer Lab (@NimerLab) profile picture
Nimer Lab@NimerLab13 Nov 2022
Kicking off day 2 with Polycomb & noncoding RNA in cancer, at the 5th Biennial Miami Cancer and Epigenetics Symposium🧬 #MiamiEpigenetics2022 @SylvesterCancer @AsifaAkhtar1 @GardiniLab @harvardmed @ShiekhattarLab
Image from Nimer Lab (@NimerLab)
Image from Nimer Lab (@NimerLab)
Image from Nimer Lab (@NimerLab)
Image from Nimer Lab (@NimerLab)
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#MiamiEpigenetics22 Great opportunities for learning and connecting. Many thanks to the organizers @SylvesterCancer and the world renowned speakers 👏👏 😊😊
Image from Chuan Chen, MD PhD (@DrChuanChen)
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We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022
Image from Sylvester Comprehensive Cancer Center (@SylvesterCancer)
Image from Sylvester Comprehensive Cancer Center (@SylvesterCancer)
Image from Sylvester Comprehensive Cancer Center (@SylvesterCancer)
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Thrilled that so many experts came to @SylvesterCancer symposium to discuss their most promising and recent research findings AND brainstorm to establish collaborations and help the trainees advance their science and career!
Sylvester Comprehensive Cancer Center (@SylvesterCancer) profile pictureSylvester Comprehensive Cancer Center
@SylvesterCancer13 Nov 2022
We had a great turnout this weekend at the 5th Biennial Miami Epigenetics and #Cancer Symposium with engaging talks from speakers representing the top #cancer #research institutions in the nation and internationally. #MiamiEpigenetics2022
Image from Sylvester Comprehensive Cancer Center (@SylvesterCancer)
Image from Sylvester Comprehensive Cancer Center (@SylvesterCancer)
Image from Sylvester Comprehensive Cancer Center (@SylvesterCancer)
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Shiekhattar Lab retweeted
Nimer Lab (@NimerLab) profile picture
Nimer Lab@NimerLab15 Nov 2022
Impactful symposium in Miami this weekend! Some of our very own @ShiekhattarLab, @lluismorey, @thecimminolab and @TaylorJ_MD discussing the latest discoveries in cancer and epigenetics research. @SylvesterCancer #MiamiEpigenetics2022
Image from Nimer Lab (@NimerLab)
Image from Nimer Lab (@NimerLab)
Image from Nimer Lab (@NimerLab)
Image from Nimer Lab (@NimerLab)
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