PhD Candidate at BC Children's Hospital Research Institute University of British Columbia
Joined July 2022
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- Following15
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Simran Samra retweeted
A surprising and exciting observation !
Human germline biallelic loss-of-function OSMR variants cause severe allergic disease rupress.org/jhi/article/2/4/…
Simran Samra retweeted
New human inborn error of immunity!
By identifying biallelic OSMR deficiency as a novel Primary Atopic Disorder, we uncover a previously unrecognized mechanism driving severe allergic disease and provide new insights into the biology of human atopy.
New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50
#Immunology #Genetics #Atopy #IEIs
Simran Samra retweeted
New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50
#Immunology #Genetics #Atopy #IEIs
Simran Samra retweeted
Rare children's genetic disease found in B.C. - Vancouver Is Awesome vancouverisawesome.com/highl…
Simran Samra retweeted
New rare disease discovered in teen brothers at BC Children’s Hospital | Globalnews.ca globalnews.ca/news/10295547/…
Simran Samra retweeted
@TurveyLab has branched out into neurodevelopment with this new preprint linking gene changes in MARK4 to pediatric neurodevelopment!
Led by PhD student Simran Samra.
@CatherineMBiggs @vaseghi_maryam @_areeshasalman @bhavi_modi_
Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism medrxiv.org/cgi/content/shor… #medRxiv