Professor at Imperial researching DNA replication & epigenetics using integrative biology approaches. Love collaborative work + interest in drug screening.
London, England
Joined April 2015
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PhD opportunity at Imperial & MRC LMS!
Designing peptides to uncover cancer vulnerabilities at telomeres with Christian Speck, Anna Barnard & Alexis Barr.
Start: October 2027
lms.mrc.ac.uk/work-and-study…
#PhDOpportunity #CancerResearch
Combine biochemistry, peptide design & synthesis, computational modelling and quantitative cell imaging to study ALT cancers.
We welcome biochemistry, chemistry, molecular biology & related backgrounds. No need for experience in every area!
Please share!
🧬 How is the replicative helicase switched on?
Our new Nature Communications paper shows how DDK phosphorylation creates Sld3-binding sites on MCM2-7, enabling Cdc45 delivery to the Mcm2/Mcm5 interface and promoting CMG assembly.
nature.com/articles/s41467-0…
🧬 Delighted to share our new Nature Communications paper! We show how MCM2-7 double hexamers become active helicases and trigger DNA melting in vivo. Led by Chris Weekes & L. Maximilian Reuter. Congratulations to the whole team!
doi.org/10.1038/s41467-026-7…
#DNAReplication
📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch.
#PhDStudentship #LifeSciences #DNAReplication #CRISPR
📢We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) - a major driver of tumour evolution and therapy resistance.
#PhD #CancerResearch
FindAPhD.com
🚨Interdisciplinary PhD opportunity for graduates interested in DNA replication, chromatin biology, and cancer research. Please share with potential candidates.
📢We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) - a major driver of tumour evolution and therapy resistance.
#PhD #CancerResearch
FindAPhD.com
📢We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) - a major driver of tumour evolution and therapy resistance.
#PhD #CancerResearch
FindAPhD.com
Twitter, I need your help. Is AlphaFold 2/3 good in predicting protein-protein interactions involving beta sheets?
To all postdocs. Are you ready to start your semi-independent career? The BBSRC Fellowship call is open. We could host you if you work in the area of DNA replication/chromatin/cancer and like to use protein biochemistry, genomics, cryo-EM, AlphaFold, MD…
tinyurl.com/bdd2yv8z
📢New Publication Alert📢 Here, we investigated how DNA insertion during pre-RC formation is linked to Mcm4 ATP hydrolysis.
Congratulations to @morvorenlowen @ma89rta
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis | Nature Communications
Christian Speck retweeted
PREPRINT OUT! Cell cycle regulation is not limited to conserved TFs. Select young TFs (29-105myo) 1) regulate cell cycle genes and 2) set the #ReplicationTiming of gene clusters. Brainchild of @ForeyRomain and @PulverCyril. doi.org/10.1101/2024.11.04.6…
Great science, fantastic opportunity to learn, and an exciting project. I strongly recommend applying.
I have two PhD positions available in my group next year! These projects are looking at how disordered regions alter protein dynamics. One is through the Yorkshire BBSRC DTP, advertisement to come, but more information can be found here: whiterose-mechanisticbiology…
Christian Speck retweeted
I have two PhD positions available in my group next year! These projects are looking at how disordered regions alter protein dynamics. One is through the Yorkshire BBSRC DTP, advertisement to come, but more information can be found here: whiterose-mechanisticbiology…
Christian Speck retweeted
Great kickoff for the EMBO EMBL Replication symposium with amazing structural and functional insights into initiation, elongation and histone recycling 🧬♻️ @TyeBik @CostaLabCrick @BleichertLab @Speck_Lab Chistol @Lopes_Lab Méchali @YardimciLab 🙌
#EESReplication @EMBLEvents
Christian Speck retweeted
One week left to apply for a cryoEM facility manager position @SussexUni
If you want to be an integral part of the growing community of researchers imaging the molecules of life in human disease then this is the job for you!
jobs.sussex.ac.uk/job/0fc719…
📢Are you interested in cryo-EM, AI and Machine Learning? Then please check out the open #PhDposition in @Specklab and Yuriy Chaban’s group - Developing AI Approaches to Uncover Regulatory Protein Dynamics in DNA Replication at the MRC LMS on FindAPhD.com
Link to the advert:
findaphd.com/phds/project/de…
Christian Speck retweeted
Another chance to join us at Birmingham. This time open also to ECRs and junior independent researchers. Genome biology is one of the priority areas (as is cancer and RNA biology). Have a look 😀. Get in touch 😀
We're delighted to announce the next cycle of recruitment for our 125th Anniversary Fellows and Chairs is now open! If you are an academic with a strong portfolio of global-leading research, we want to hear from you. Check out our vacancies and apply now: fellowsandchairs.birmingham.…