Yang Zhang (@SwitFluors) header
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Yang Zhang

@SwitFluors

Assistant Professor at North Carolina State University. Fluorescent Dyes, Single-Molecule Microscopy, Molecular Switches.

 Raleigh, NC
sites.google.com/view/mapperncsu/
Joined January 2018
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Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)Photo by Yang Zhang (@SwitFluors)
1/Excited to share our new preprint: SIMBA: an agentic AI platform for single molecule multi dimensional imaging: biorxiv.org/content/10.64898… and simba-website-indol.vercel.a…
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3/These barriers can slow discovery, especially for interdisciplinary teams. SIMBA explores how agentic AI can support this process and allows users to guide workflows through natural language and connect those goals to domain specific computational tools.
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4/The platform combines single molecule localization, spectral analysis, deep learning based denoising, and interactive data workflows. It is designed to support reproducibility, transparency, and broader access to advanced imaging analysis.
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Heading to #BPS2026 in San Francisco? Come check out our poster on: 🧪 MAP Fluorophores: Switchable and Environment-Sensitive Probes for Functional Super-Resolution Microscopy 📌 Poster LB103 🗓 Feb 23, 2026 | ⏰ 1:45 PM 📍 Moscone Center, Exhibit Halls ABC
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We will share our published work and unpublished probes from the MAP series, including switchable and environment-sensitive dyes designed for multi-dimensional single-molecule imaging. Interested in probes, membrane biophysics, chromatin imaging, and functional SRM? Let's connect
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At SPIE Photonics West tomorrow? Join our talk on how deep learning improves single-molecule spectroscopic imaging. Jan 17 10:20–10:40 AM PST Room 152, Moscone South Hongjing Mao: A Monte Carlo–Based Deep Learning Framework for Accurate Single-Molecule Spectroscopic Imaging
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Heading to Pacifichem in Honolulu? 🌺 If you are interested in new fluorescent probes for super-resolution microscopy, please stop by and check out two presentations from our Molecular Analytics and Photonics (MAP) Lab:
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🔹 Oral Presentation I will present our recent advances integrating photoswitchable and PAINT-based probes and single-molecule spectral imaging toward multi-functional super-resolution microscopy. 📅 Dec 19 | ⏰ 4:00–4:15 PM (local time) 📍 Room 304A, Hawaii Convention Center
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🔹 Poster Presentation Xiayi Gong will present our work on solvatochromic BODIPY fluorophores, highlighting single-molecule spectral heterogeneities and polarity sensing. 📅 Dec 18 | ⏰ 10:00–11:30 AM (local time) 📍 Exhibit Hall, Hawaii Convention Center
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Solvatochromic BODIPYs with Polarity-Independent Absorption for Functional Super-resolution Imaging of Live Cell Membranes | Chemical & Biomedical Imaging pubs.acs.org/doi/10.1021/cbm…
Solvatochromic BODIPYs with Polarity-Independent Absorption for Functional Super-resolution Imaging...

Solvatochromic BODIPYs with Polarity-Independent Absorption for Functional Super-resolution Imaging...

Abstract. Functional super-resolution microscopy (SRM) has recently emerged as a powerful technique for concurrently mapping nanoscale physicochemical prop

pubs.acs.org
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Have you used Nile Red for super-resolution microscopy? We have made a new BODIPY-based solvatochromic dye that is brighter, redder, and more sensitive and tested it for live-cell SMLM/PAINT. We would like anyone interested to test our dyes! DM or email to get a free sample!
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My group at NC State is seeking a talented and motivated postdoctoral fellow to advance next-generation single-molecule imaging technologies. The position is immediately available. ✉️ If you're interested, feel free to DM me or reach out via email at [email protected].
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Preferred Background: PhD in biophysics, biomedical engineering, optics, or related fields. Experience with SMLM, fluorescence microscopy, or computational imaging is a plus.
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What You’ll Work On: Single-molecule spectroscopy and localization microscopy Custom optical system and imaging method development Image processing & machine learning Functional imaging in live cells
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Check out our recent publication on Framework for Accurate Single-Molecule Spectroscopic Imaging Analyses Using Monte Carlo Simulation and Deep Learning | Analytical Chemistry, led by PhD student Hongjing Mao pubs.acs.org/doi/10.1021/acs…
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📢 We're Hiring! Join Our XIQI Lab at Northwestern University We have openings for postdocs and research assistants to develop optical imaging technologies. 📩 Please reach out to me by email if you're interested. 🔗 More details: sites.northwestern.edu/xiqil… #Hiring
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Check out our recent collaborative work with Raymo and Sortino groups on discovering green-light activatable BODIPYs for super-resolution imaging of live cells: Photoactivation of BODIPY Fluorescence with Green Light | The Journal of Organic Chemistry pubs.acs.org/doi/abs/10.1021…
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Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membrane Imaging | Journal of the American Chemical Society @aprahamian @dartmouth @NCStateChemGSA @NCStateChem @NCState @unccollege @UNC pubs.acs.org/doi/10.1021/jac…
Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membrane Imaging

Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membrane Imaging

Abstract. Advancing the field of super-resolution microscopy will require the design and optimization of new molecular probes whose emission can be toggled

pubs.acs.org
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Check out our recent collaboration with Ivan Aprahamian's lab @dartmouth on developing Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membrane Imaging | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac….
Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membrane Imaging

Photoswitchable Fluorescent Hydrazone for Super-Resolution Cell Membrane Imaging

Abstract. Advancing the field of super-resolution microscopy will require the design and optimization of new molecular probes whose emission can be toggled

pubs.acs.org
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