Schmitt-MechulamLab (@TBioc) profile picture

Schmitt-MechulamLab

@TBioc

Translation mechanisms group at the Ecole polytechnique BIOC laboratory.

 Palaiseau
portail.polytechnique.edu/bioc/en/research/translation-initiation
Joined February 2020
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Photo by Schmitt-MechulamLab (@TBioc)Photo by Schmitt-MechulamLab (@TBioc)Photo by Schmitt-MechulamLab (@TBioc)Photo by Schmitt-MechulamLab (@TBioc)Photo by Schmitt-MechulamLab (@TBioc)Photo by Schmitt-MechulamLab (@TBioc)Photo by Schmitt-MechulamLab (@TBioc)
Our work on ribosome hibernation in Archaea is out. We identified Hib, a new hibernation factor broadly distributed across Archaea. Great collaboration between @TBioc @Ifremer_fr @CbiToulouse @institutpasteur Check out the preprint: biorxiv.org/content/10.1101/…
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Zeynep Baharoglu (@BaharogluZeynep) profile picture
Zeynep Baharoglu@BaharogluZeynepJun 1
Ribosome heterogeneity in E. coli : ribosomal RNA (rRNA) sequence and modifications, r-protein stoichiometry and PTMs, and ribosome-associated proteins pubs.acs.org/doi/10.1021/jac… 🦠
Ribosome Heterogeneity Revealed by Complex-Up Native Mass Spectrometry and Top-Down Proteomics

Ribosome Heterogeneity Revealed by Complex-Up Native Mass Spectrometry and Top-Down Proteomics

Abstract. Characterization of large molecular machines, such as the ribosome, under a breadth of biological states to elucidate regulatory details remains

pubs.acs.org
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Evgenii Protasov (@protasov_evgeni) profile picture
Evgenii Protasov@protasov_evgeniMay 17
Thought-provoking read "The selfish ribosome" #evolution #microbiology @PLOSBiology journals.plos.org/plosbiolog…
Image from Evgenii Protasov (@protasov_evgeni)
Image from Evgenii Protasov (@protasov_evgeni)
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Very happy to share our latest publication in Nat. Commun. nature.com/articles/s41467-0… It was a greatcollaboration with @Ifremer_fr, @CbiToulouse and Institut Pasteur. We discovered a new hibernation factor in Archaea binding to the ribosome in three different conformations !
Image from Schmitt-MechulamLab (@TBioc)
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Eriani-Martin lab (@ErianiLab) profile picture
Eriani-Martin lab@ErianiLabMay 5
N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease | Translational Neurodegeneration | Springer Nature Link link.springer.com/article/10…
N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional...

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional...

Translational Neurodegeneration - Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), characterized by progressive accumulation of pathological Tau...

link.springer.com
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Rockefeller University (@RockefellerUniv) profile picture
Rockefeller University@RockefellerUnivMay 4
In @MolecularCell: RNA polymerase, the enzyme that synthesizes RNA from DNA during transcription, has been captured mid-reaction for the first time by scientists in Seth Darst's lab at Rockefeller. 🔗: bit.ly/4ur3Vaz
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Richard H. Ebright (@R_H_Ebright) profile picture
Richard H. Ebright
@R_H_EbrightMar 20
Structural basis of translation in transcription-translation coupling (Collaboration between our laboratory and the laboratories of Xiaogen Zhou, Jinzhong Lin, and Chengyaun Wang. Extensively expanded preprint. Posted 03/26/26.) biorxiv.org/content/10.1101/…
Image from Richard H. Ebright (@R_H_Ebright)
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NatureStructMolBiol (@NatureSMB) profile picture
NatureStructMolBiol@NatureSMBMar 18
New online! Ribosome-associated quality control and related mechanisms dlvr.it/TRYXWG
Image from NatureStructMolBiol (@NatureSMB)
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Evgenii Protasov (@protasov_evgeni) profile picture
Evgenii Protasov@protasov_evgeniMar 6
Asgard archaea: have we found our microbial ancestors? #microbiology #archaea #eukaryotes #evolution @EMBO link.springer.com/article/10…
Image from Evgenii Protasov (@protasov_evgeni)
Image from Evgenii Protasov (@protasov_evgeni)
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Evgenii Protasov (@protasov_evgeni) profile picture
Evgenii Protasov@protasov_evgeniFeb 17
Sporulation: the expensive insurance policy of bacteria🦠 Why do #bacteria spend massive amounts of #ATP to shut down exactly when they are running out of food? By integrating genome, transcriptome, and proteome data, researchers have mapped the full energetic "price tag" of a bacterial spore. #microbiology @PNASNews doi.org/10.1073/pnas.2524274…
Image from Evgenii Protasov (@protasov_evgeni)
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Tomas Malinauskas (@t_malinauskas) profile picture
Tomas Malinauskas@t_malinauskasFeb 14
Self-replicating molecules such as RNA are considered a plausible foundation for the origin of life on Earth. A remarkably small RNA molecule of only 45 nucleotides (QT45) that can synthesize itself and its complementary strand is now published in Science: science.org/doi/10.1126/scie…
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Tominaga K. (tomiken) (@pacyc1841) profile picture
Tominaga K. (tomiken)@pacyc1841Feb 7
The paradox of immune systems conservation between prokaryotes and eukaryotes | Nature Reviews Microbiology nature.com/articles/s41579-0…

The paradox of immune systems conservation between prokaryotes and eukaryotes

Nature Reviews Microbiology - The widespread prokaryotic immune systems, in particular restriction–modification, CRISPR–Cas and defensive toxin–antitoxin systems, are absent in...

nature.com
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Haselbach lab (@HaselbachLab) profile picture
Haselbach lab@HaselbachLabJan 22
the 4th paper in this week contribution from our lab tells about ribosome biogenesis in yeast. A follow-up story from our wonderful collaborators @UniGraz - the Bergler Lab. Structural work was again done by the amazing Lorenz Grundmann academic.oup.com/nar/article…
A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic...

A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic...

Abstract. Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) whil

academic.oup.com
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Israel Fernandez (@IsraelF96135088) profile picture
Israel Fernandez@IsraelF9613508827 Nov 2025
😱
Niko McCarty. (@NikoMcCarty) profile pictureNiko McCarty.
@NikoMcCarty25 Nov 2025
Japanese researchers found a new type of archaea with the smallest known genome: 238k bases. They live inside ocean-dwelling dinoflagellates as symbiotes. Their genome "encodes the barest minimum of proteins for its own replication." All other molecules are taken from the host.
Image from Niko McCarty. (@NikoMcCarty)
Image from Niko McCarty. (@NikoMcCarty)
Image from Niko McCarty. (@NikoMcCarty)
Image from Niko McCarty. (@NikoMcCarty)
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Israel Fernandez (@IsraelF96135088) profile picture
Israel Fernandez@IsraelF9613508819 Nov 2025
tRNAs for the win!
David R. Liu (@davidrliu) profile pictureDavid R. Liu
@davidrliu19 Nov 2025
Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature stop codons across different diseases. (1/15) drive.google.com/file/d/1bSv…
Image from David R. Liu (@davidrliu)
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Evgenii Protasov (@protasov_evgeni) profile picture
Evgenii Protasov@protasov_evgeni13 Nov 2025
Analysis of Mechanisms for Electron Uptake by Methanothrix harundinacea 6Ac During Direct Interspecies Electron Transfer #microbiology #methanogens #methane @MDPIOpenAccess mdpi.com/1422-0067/26/9/4195
Image from Evgenii Protasov (@protasov_evgeni)
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Sergej Djuranovic (@DjuranovicLab) profile picture
Sergej Djuranovic
@DjuranovicLab6 Nov 2025
Replying to @slavicaPD
@slavicaPD and Jessey Erath's view on new Plasmodium ribosome structures. Seeing is believing—Plasmodium falciparum translation in action sciencedirect.com/science/ar…
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Nature Chemical Biology (@nchembio) profile picture
Nature Chemical Biology@nchembio3 Oct 2025
Engineered aminoacyl-tRNA synthetase mutants facilitate ultrafast bioorthogonal tagging with multiple noncanonical acids for multiplexed nascent proteome profiling in response to different cues in diverse bacteria nature.com/articles/s41589-0…
Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics

Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics

Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...

nature.com
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Israel Fernandez (@IsraelF96135088) profile picture
Israel Fernandez@IsraelF9613508813 Sep 2025
Tour de force!
This Post is from an account that no longer exists. Learn more
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CNRS 🌍 (@CNRS) profile picture
CNRS 🌍
@CNRS11 Sep 2025
#Communiqué 🗞️ La médaille d'or 2025 du CNRS est décernée à Stéphane Mallat, mondialement reconnu pour ses travaux autour des mathématiques appliquées au traitement du signal et à l’intelligence artificielle. 👏 👉 cnrs.fr/fr/presse/entre-math… #TalentsCNRS 🏅
Image from CNRS 🌍 (@CNRS)
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