Associate Professor @UZH_en @Unispital_USZ @CCCZ_USZ studying the pathogenesis of cancer with a particular focus on TP53-mutant myeloid (pre-)malignancies
Zurich, Switzerland
Joined May 2019
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🔥New paper from our lab @UZH_en @Unispital_USZ @CCCZ_USZ 🔥
#ERCC6L2 disease is a relatively recently described inherited bone marrow failure syndrome. It is strongly associated with somatic #TP53mutations and #AML or #MDS development. 1/7
ashpublications.org/blood/ar…
Boettcher Lab retweeted
How does leukaemia develop? 🩸 How long does it take? ⏳
🌟 Our paper, started back when I was a PhD student in @jrblundell’s lab, is out today in @Nature 🌟
Yearly blood samples from women who developed AML in later life let us trace it back decades 👇
doi.org/10.1038/s41586-026-1…
Boettcher Lab retweeted
Super happy to be back to my 2nd home, USZ in Zurich and see my ex mentor, colleagues and friends!!!! Was also honor to give a talk in Dept. of Onco-Hematology led by Prof. MG Manz.
Boettcher Lab retweeted
Our latest work, uncovering the origins of microglia in human aging! Link to article below
👇
Gaining therapeutic access to the human brain is one of the biggest unsolved problems in biomedical science.
Today @nature, we uncover a massive influx of immune cells into the human brain during aging, revealing that the brain is more accessible than previously thought. 1/
nature.com/articles/s41586-0…
Boettcher Lab retweeted
At #EHA2026, the #HemaSphereAwards recognize authors of influential hematology publications. Congratulations to Ana Luísa Pereira, Serena Galli, and César Nombela-Arrieta for their study on bone marrow niches for hematopoietic stem cells👉onlinelibrary.wiley.com/doi/…
Boettcher Lab retweeted
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr
Boettcher Lab retweeted
Ercc6l2 deficiency leads to replication stress, p53 pathway activation, and decreased Runx1 and Gata1 expression resulting in BMF. Read the plenary paper in Blood: ow.ly/nZ5l50YGL8b #plenarypaper #bloodjournal #p53
I’m also very delighted to share the news that I have been promoted to #AssociateProfessor. @UZH_en @Unispital_USZ @CCCZ_USZ 🍾🥂🎉
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Bonus 1/2: Thanks to #Timothy_Chlon for his insightful commentary on our work!
ashpublications.org/blood/ar…
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Bonus 2/2: Thanks to #Dr. James D. Griffin for featuring our work on the @BloodPortfolio podcast. bloodpodcast.transistor.fm/e…
Boettcher Lab retweeted
Welcome to #ESHAL2026!
Stay tuned! ESH Young Scientific Reporters @DKotsos & @TanMeg9595 will provide regular updates on the conference!
February 27-March 1, 2026
Chairs: @DombretHerve, Christoph Röllig, @DrWendyStock
#ESHCONFERENCES #leusm
@Hemasphere_EHA
