The McLuckey Lab at Purdue (@TheMcLuckeyLab) header
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We seek to advance the mass spectrometry of bio-complexes, proteins, nucleic acids, and lipids via ion chemistry research and instrument development.

Joined April 2021
Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)Photo by The McLuckey Lab at Purdue (@TheMcLuckeyLab)
Seth is on a roll 😎, the man has published/co-published three papers in the last 3 months 🫡👷. For ion-ion reaction aficionados - Parallel valet parking: selective ion escape over an AC barrier during ion/ion reactions in a quadrupole linear ion trap cdnsciencepub.com/doi/full/1…
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You say you are a proton transfer charge reduction (PTCR) user? We have something for you 😎: Proton transfer reagent cations for ion–ion charge state manipulation of high mass negatively-charged analytes in an electrodynamic ion trap pubs.rsc.org/en/content/arti…
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Congratulations to our entire cohort of third-year students, specially Mr. Ellin and Zuzu (Boukar). Interestingly, all those guys started their program together. Classic example of team effort 👌 👌🏿. Hope you enjoy the reading 😁.
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Recently, we developed a couple of methods to aid in the mass analysis of proteins dissolved in physiologically relevant conditions. Now, we are showing why it is important to preserve proteins native environment. The conformational dynamics simply change. pubs.rsc.org/en/content/arti…
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Big congratulations to our very bright and hardworking Dr. Erick Baez Bolivar for defending his dissertation today! He's accomplished so much during his time with us including an internship at Merck in California. His passionate energy will be missed dearly!
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Our dear Sam defended her PhD thesis last week, we couldn't be prouder. Dr. Mehnert, you will be immensely missed!!!..thanks for everything you have been doing for the group, from scientific contributions to keeping the culture of the lab alive and thriving. Next stop..stay tuned
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It is a pleasure for us to announce that our dear Sam recently started a postdoc position at @EliLillyandCo. She will be scientifically entertained in the Protein Synthesis Lab 🤓. We wish her a successful postdoc 😀. Have fun and learn a lot Sam 🤗!
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The McLuckey Lab at Purdue retweeted
⚛️ “You can’t plan discoveries – but you can plan work that’s likely to lead to discoveries.” In this article, Scott A. McLuckey (@LifeAtPurdue) shares his lifelong passion for curiosity-driven science and the thrill of turning over stones in mass spectrometry. 🔗 ow.ly/Yr6K50XbMFB #MassSpec
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Here is our dear Nick Pizzala presenting his research to the wide audience of the @TopDownProteome. Although our guy has no problem talking, it is an 8-minute summary of excellent research. youtu.be/59IKJKaMTW0?si=FbmE…
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The McLuckey Lab at Purdue retweeted
@UFChemistry is searching for an Assistant Professor in #AnalyticalChemistry! Join our vibrant and state-of-the-art program and faculty! Apply by Oct. 31. careers.pageuppeople.com/674…
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Starting with a simple desire to improve reproducibility of the spectra, we found out significant improvements on repeatability, S/N, FWHM (less metal ion adduction), and robustness. If you are interested in small proteins, the house suggests going all-in solution additives
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Now, if you are interested in relatively high MW proteins (466 kDa tested in our work), please use small portions. The thing can be sticky. We explained the recipe in the manuscript. Happy reading!
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It's (e)lit! We have a new article about the homebuilt nested ELIT, which allows for an extended mass range while also maintaining higher resolution. Read below to see how it works! doi.org/10.1016/j.ijms.2025.…
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In this work, we apply DDC to doubly-charged bradykinin. However, using an MCP can result in ions with different charges being detected at different efficiencies, which leads to incorrect calculations. How do we account for this? Find out below! doi.org/10.1016/j.ijms.2025.…
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The McLuckey Lab at Purdue retweeted
We have several staff positions open in our Amy Instrumentation Facility. Check them out: chem.purdue.edu/facultyopeni… #chemjobs
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This Special Issue honors Prof. Dame Carol Robinson, 2023 ASMS John B. Fenn Award recipient. Featuring works from esteemed authors she invited, showcasing her transformative impact on native & structural mass spectrometry. Read it here: brnw.ch/21wTFRW @ASMSnews
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