@ThePasareLab
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Welcome to the Pasare Lab at CCHMC. Our lab studies TLR signaling pathway and how activation of TLRs influence the shaping of the adaptive immune responses.
Cincinnati, OH
Joined July 2018
- Tweets39
- Following42
- Followers495
- Likes71
Pasare Lab retweeted
Elevate your knowledge with the Distinguished Lectures at #IMMUNOLOGY2025™. Engage with thought leaders and gain unique perspectives. Register today: immunology2025.aai.org.
#WednesdayWisdom
I had once said to Rana " It is not possible to reverse fibrosis" She is well on her way to prove me wrong. Huge implications for diseases where fibrosis results in morbidity and mortality. Congratulations! Rana Herro @herro86957 @CincyChildrens
#PulmonaryFibrosis (PF) is a condition that leads to the buildup of scar tissue in the lungs. A new study published in @J_Immunol by @herro86957 @CincyResearch identified two novel mediators of PF and demonstrated that targeting both can reverse scarring. ow.ly/ZcIy50VyRxs
Pasare Lab retweeted
Check out an article about the study from UW... eurekalert.org/news-releases…
Congratulations! Nandan. Delighted that @nandangokhale will be on the faculty of the Division of Immunobiology @CincyChildrens soon. Can't wait to see how his exciting research unfolds. Welcome! Nandan.
So excited to join the Division of Immunobiology at Cincinnati Children's Hospital MC in March 2025. My lab will study how RNA biology regulates and is regulated by infection and immunity.
We'll be hiring at all levels in 2025 - stay tuned!
gokhalelab.com/
Join us @CincyChildrens to do exciting research in Immunology. Please apply and forward to colleagues.
nature.com/naturecareers/job…
Memory T cell derived TNF: Primary activator of innate immune system to drive transplant rejection
Intriguing new approach to preventing #HeartTransplant rejection shows early promise in mice. Congrats to @ThePasareLab @CincyChildrens @CincyKidsHeart scienceblog.cincinnatichildr…
Activation of the innate immune system by memory T cells (not PAMPs) is the primary driver of transplant rejection @ThePasareLab @CincyChildrens
pnas.org/doi/10.1073/pnas.24…
Pasare Lab retweeted
CCHMC Division of Immunobiology is hiring faculty (at all ranks).
Applicants should send a CV, 2-page research plan, and contact information for three
references to Immunobiology@cchmc.org by March 1st, 2024.
Effector memory CD4 T cells drive DNA damage in Dendritic cells to activate non-canonical STING pathway and subsequent innate inflammation. Stellar work by Hannah Meibers, a graduate student in the lab @CincyChildrens @CincyImmunology @ThePasareLab
cell.com/cell-reports/fullte…
Congratulations! Aakanksha. Very proud of you
Excited to share that I have received the NIH HEAL K99 award to study the neuroimmune mechanisms of recurring pain. Thanks to my mentors Clifford Woolf @FMKirbyNeuro and @ThePasareLab for guidance and my amazing labmates for reading and re-reading my grant against their will 🤓.
Pasare Lab retweeted
IEC-intrinsic IL-1R enhances IL-22–induced AMPs for protection vs C. rodentium, but contributes to damage-induced inflammation via chemokines & ROS. Congrats Hannah, Garrett, Lisa & @ThePasareLab @kellivd @AlenghatLab @CincyImmunology
doi.org/10.1084/jem.20212523
Pasare Lab retweeted
Overcast, Meibers et al. @ThePasareLab @CincyChildrens characterize the dual role of IL-1R signaling in IECs during C. rodentium infection and DSS-induced #colitis. bit.ly/3KaPqn7
#MucosalImmunology #InnateImmunity #inflammation
Active role for gut epithelial cell IL-1R in fine tuning IL-22 induced anti-microbial response and inflammation through induction of ROS.
rupress.org/jem/article/220/…
Division of Immunobiology @CincyChildrens is looking for a new leader. Great place to do exceptional science. Please spread the word and apply
jobs.cincinnatichildrens.org…
Pasare Lab retweeted
Potential Approach Emerges to Treat Autoimmunity and Prevent Serious Side Effects of #Cancer Immune Therapies. Congrats to @ThePasareLab @ChildrensCBDI #cytokinestorms scienceblog.cincinnatichildr…
CD4 T effector memory T cells engage TNFR and CD40 on DCs to cause auto-immune pathology and cytokine storm. New targets for combating T cell induced innate inflammaton. @ThePasareLab @_m_mcdaniel @Aakanksha__Jain @CincyChildrens @CincyImmunology
science.org/doi/10.1126/scii…
Pasare Lab retweeted
Study @NatImmunol reveals how the body's innate #ImmuneSystem senses allergens like #mites, #insects and #fungi. Suggests new targets for treatment. Congrats @RothenbergLab @ThePasareLab ! #inflammation #allergies #foodallergies scienceblog.cincinnatichildr…
Allergens activate Ripoptosome to drive Caspase-8 mediated cleavage of IL-33.A step closer to type II sensor? @RothenbergLab @ThePasareLab @CincyChildrens
nature.com/articles/s41590-0…
Pasare Lab retweeted
Not all phagocytes respond similarly to TLR ligands--an important examination of the role of IRF1. Kudos to @ThePasareLab and colleagues on this important discovery.
cell.com/cell-reports/fullte…
Pasare Lab retweeted
Congrats @ThePasareLab @Kottyan_Lab on manuscript showing TLR4 signaling in Mf, but not monocytes, enables nuclear translocation of IRF1, which acts as a pioneer TF to increase the chromatin accessibility of IFNB1 and ISG loci.
cell.com/cell-reports/pdf/S2…