Iva Tolić (@Toliclab) header
Iva Tolić (@Toliclab) profile picture

Iva Tolić

@Toliclab

Moved to https://nitter.cf/t.co/qqX1gi2P81! Biophysics of Mitosis @institutrb, @EMBO member; Ex Group Leader @mpicbg, PD @UNI_FIRENZE, @uni_copenhagen, PhD @PMFZAGREB

 Zagreb, Croatia
tolic.irb.hr
Joined June 2018
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The mitotic spindle fan club #SpindleCroatia2026 phy.pmf.unizg.hr/~mitosis/
Image from Iva Tolić (@Toliclab)
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Arrived in Dubrovnik for the @EMBO Scientists' Forum! Organized by EMBO Installation Grantees Damir Baranašić, Jelena Bujan & Jelena Godrijan from the Ruđer Bošković Institute, and Marko Šestan from the University of Rijeka. Congrats and thanks for inviting me!
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How does the mitotic spindle adapt to genomes that differ in size by more than 10,000-fold? Our new paper in @NatureCellBio reveals a simple scaling law and the physics behind it: chromosome crowding! 🧵 nature.com/articles/s41556-0…
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Huge congrats to first authors @LovroGudlin, @KrunoVuk & Maja Novak! This was a super fun collaboration with @nenad_pavin, including our whole @ERC_Research Synergy team, Geert Kops and MIT. Special thanks to @ZStorchova and @hrzz_science. Proud of the team!
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Finally, thanks to Jing Xie and Dani Fachinetti @FachinettiLab for writing a beautiful News & Views about our paper: nature.com/articles/s41556-0…
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CELL LA VIE is getting started at Institut Pasteur! Looking forward to great talks and catching up with friends and colleagues. I’ll be speaking on Friday. 😊🔬✨
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Congrats to Deisseroth, Hegemann & Nagel on the #NobelPrize for optogenetics! Here's how we used this cool tool to study cell division.
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Optogenetics was our "remote control": light ON pulled the protein PRC1 off the mitotic spindle mid-division, light OFF brought it back. Without PRC1, the spindle changed shape and chromosomes struggled to line up.
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Big thanks to the team: Mihaela Jagrić, Patrik Risteski @risteski_, Jelena Martinčić & Ana Milas! 🙌 elifesciences.org/articles/6…
Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap...

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap...

Optogenetic experiments show that bridging microtubules buffer chromosome movements and promote their alignment through forces transferred to the associated kinetochore fibers, which rely on precise...

elifesciences.org
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Ahead of the CeNS/BioSysteM interdisciplinary workshop at Venice International University
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At President Zoran Milanović’s office! As #CROSCIENCE organizers, we talked about science, Croatian scientists at home and abroad, and CROSCIENCE 2026. croscience.org/ Photo: Office of the President of the Republic of Croatia / Tomislav Bušljeta
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Thanks, @BPoD_s!
Biomedical Picture of the Day BPoD (@BPoD_s) profile pictureBiomedical Picture of the Day BPoD@BPoD_sSep 4
Spindle elongation in cell division can rescue chromosomes straying to the poles so avoiding abnormal chromosome number/cell 📹 @isabella__k & Valentina Štimac et al @Toliclab @institutrb in @NatureComms ➡️ bpod.org.uk/archive/2026/9/4 + @DrJohnAnkers
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Spindle elongation in cell division can rescue chromosomes straying to the poles so avoiding abnormal chromosome number/cell 📹 @isabella__k & Valentina Štimac et al @Toliclab @institutrb in @NatureComms ➡️ bpod.org.uk/archive/2026/9/4 + @DrJohnAnkers
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Exciting collab with @luijsterburglab! It was great to have Sjoerd Klaasen visit our lab to work with @KrunoVuk!
Martijn Luijsterburg (@luijsterburglab) profile pictureMartijn Luijsterburg@luijsterburglabAug 12
New preprint from the lab on mechanisms of KIF18 inhibitor resistance, led by Sjoerd Klaasen in collaboration with @Toliclab and @haicovanattikum. biorxiv.org/content/10.64898…
Image from Martijn Luijsterburg (@luijsterburglab)
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See you in Split!
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It was great to give a talk on "One Law Linking Genomes and Spindles Across Life" at the 12th International Conference on Biological Physics #ICBP2026 in Genoa! Exciting science and a spectacular location in the old harbor. Many thanks to Alberto Diaspro & the organizing team!
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