Scientist studying biological tissues with neuronal circuits inside. Tweets my own. Aquí, tuitejo el què em passa pel cap molt de tant en tant.
Joined October 2010
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#paper!
We imaged the same brain tissue sample with lasers, X-rays and electrons to address both its subcellular structure and its physiological function.
rdcu.be/cOiiv
A few highlights:
1/n
@AndreasTSchaefer @esrfsynchrotron @psich_en @DiamondLightSou @NatureComms
📰 A new imaging technique captures info about the structure & function of brain tissue at subcellular level and info about the surrounding environment🔎
@AndreasTSchafer @Trickymons @esrfsynchrotron @psich_en @DiamondLightSou @NatureComms
Read more ⤵️
ow.ly/sZqM50Jhp7c
Carles Bosch retweeted
Introducing a complete map of the male fruit fly brain and central nervous system, created in partnership with @HHMIJanelia. With over 166,000 neurons, this is the largest cellular brain map to date. Learn more: goo.gle/4qQTtIW
Carles Bosch retweeted
Happy to share the CA3 dataset is published. First large-scale dense connectomics from hippocampus. First connectomic dataset imaged in @PrincetonNeuro. A harbinger of many larger datasets to come (for both). doi.org/10.1038/s41593-026-0… (1/3)
Carles Bosch retweeted
Earthset.
The Artemis II crew captured this view of an Earthset on April 6, 2026, as they flew around the Moon. The image is reminiscent of the iconic Earthrise image taken by astronaut Bill Anders 58 years earlier as the Apollo 8 crew flew around the Moon.
ALT Earthset captured through the Orion spacecraft window at 6:41 p.m. EDT, April 6, 2026, during the Artemis II crew\u2019s flyby of the Moon. A muted blue Earth with bright white clouds sets behind the cratered lunar surface. The dark portion of Earth is experiencing nighttime. On Earth\u2019s day side, swirling clouds are visible over the Australia and Oceania region.\nIn the foreground, Ohm crater has terraced edges and a flat floor interrupted by central peaks. Central peaks form in complex craters when the lunar surface, liquefied on impact, splashes upwards during the crater\u2019s formation. Credit: NASA
#paper:
Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬
Safe Khan, @AndreasTSchafer
@TheCrick @embl @HiTT_Hamburg @esrfsynchrotron @id16a @imperialcollege @uclnpp
S. Khan et al.: Critical point drying of brain tissue for X-ray phase-contrast imaging #PhaseContrast #XRay #SamplePreparation @TheCrick @EMBLGrenoble @esrfsynchrotron @imperialcollege @ucl... #IUCr journals.iucr.org/paper?S160…
This work is the product of an outstanding multidisciplinary team operating across multiple countries.
Special congrats to Safe Khan, lead author of the study. And congrats to all authors and supporting institutions!
Safe Khan, @AndreasTSchafer
doi.org/10.1107/S16005775260…
Here's a spotlight article on our recent study!
Tissue ultrastructure can be resolved with X-rays, which impacts not only how we can study neuronal circuits but soft tissues more generally.
Kudos to Ana Diaz, @AdrianAWanner, @AndreasTSchafer and all authors.
🔬🔦Our latest ‘Imaging spotlight’, by
@Trickymons, Ana Diaz, @AdrianAWanner &
@AndreasTSchafer, highlights their non-destructive X-ray tomography pipeline, developed to map mouse brain ultrastructure, & considers future applications & developments
focalplane.biologists.com/20…
Read the spotlight here: focalplane.biologists.com/20…
Read the whole paper here: nature.com/articles/s41592-0…
@TheCrick @psich_en
Carles Bosch retweeted
.@NSF is launching Tech Labs to build and scale next-gen independent research organizations to advance science. These orgs will tackle technical challenges traditional university and industry labs can’t solve alone.
Share your feedback: bit.ly/44ZtMw7.
ALT Tech Labs banner with blue background and the NSF logo.
Carles Bosch retweeted
Method of the Year 2025: In his Comment, @rclayreid discusses functional connectomics, which links structure and function by combining electron microscopic reconstruction of brain tissue with calcium imaging of neuronal activity.
nature.com/articles/s41592-0…
Carles Bosch retweeted
Method of the Year 2025: In their Comment, Wei-Chung Allen Lee @darbly and Ramin Khajeh discuss alternatives to the well-established approaches used in connectomics.
nature.com/articles/s41592-0…
Carles Bosch retweeted
Method of the Year 2025: In his Comment, Moritz Helmstaedter @mh_lab looks into the future of connectomics and the feasibility of scaling up to larger brains.
nature.com/articles/s41592-0…
Carles Bosch retweeted
Connectomics is Method of the Year 2025!! @naturemethods just released the news nature.com/articles/s41592-0… In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics nature.com/articles/s41592-0… 1/3
Carles Bosch retweeted
Our Method of the Year 2025 is...drumroll please...EM-based connectomics!!
Our Editorial introduces our choice and highlights six Comments and other related content in this special issue. Please join us in celebrating EM-based connectomics! 🎉🧠🔬
nature.com/articles/s41592-0…
Carles Bosch retweeted
And read the associated Research Briefing here:
nature.com/articles/s41592-0…
Carles Bosch retweeted
An optimized X-ray nanotomography method offers an attractive alternative to volume EM for connectomics. @trickymons, @TheCrick, @psich_en, @AdrianAWanner, @AndreasTSchafer, @ucl, @uclnpp
nature.com/articles/s41592-0…
Carles Bosch retweeted
X-rays can resolve ultrastructure - a milestone for ultrastructure imaging without cutting. Thanks to an amazing team - @Trickymons @AdrianAWanner Ana Diaz and all collaborators from @TheCrick @psich_en and @esrfsynchrotron and funders @wellcometrust @UKRI_News
#paper!
X-rays can resolve #ultrastructure in #tissues non-destructively.
nature.com/articles/s41592-0…
Shoutout to key collaborators at @TheCrick and @psi_eng Ana Diaz, @AdrianAWanner and @AndreasTSchaefer, and to the whole team that made this possible.
Carles Bosch retweeted
Happy to share the first paper from my journey at @psich towards X-ray connectomics, now out in @naturemethods: nature.com/articles/s41592-0…
I was glad to receive a Science Achievement Award from @TheCrick! Thanks!!
Cheers to all co-authors of our study showing that tissue ultrastructure can be resolved by X-rays.
nature.com/articles/s41592-0…
And congrats to all the other awardees - such a pleasure to be in this lot!
